[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642606":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":33,"centralContacts":38,"locations":48,"responsibleParty":67,"collaborators":23,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":23,"eligibilityCriteria":77,"healthyVolunteers":73,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":23,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":51,"whyStopped":23,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"National Cancer Institute, Egypt","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Ultrasound guided bilevel Erector spinae plane block (ESPB)","ACTIVE_COMPARATOR","Before induction of general anesthesia, patients will be positioned in the sitting position leaning forward. The 3rd and 5th vertebral spinous processes will be first identified then the block area will be adequately sterilized and draped. The block will be done as needed using either a high frequency linear probe (6- 13 MHz) or a curved (2-5 MHz) probe of . The probe used to identify the hyperechoic transverse process shadow at approximately 1.5- 2 cm distance from the spinous process deep to the trapezius, rhomboid major, and erector spinae muscles at 3rd, 5th vertebrae. Then, an 18-gauge epidural needle will be inserted in a cephalad-to-caudad direction to reach the transverse process deep to the erector spinae muscle. Correct positioning of the needle will be confirmed through real time visualization of 2 ml saline hydro dissection at both 3rd and 5th vertebrae.20 ml of bupivacaine 0.25% will be injected at each level.",[13],"Procedure: Ultrasound guided bilevel Erector spinae plane block (ESPB)",{"label":15,"type":10,"description":16,"interventionNames":17},"Ultrasound guided Pectoserratus Block (PSPB)","For the PECS block, the patient's arm is abducted 90° and externally rotated. The ultrasound probe is positioned beneath the lateral third of the clavicle to locate the axillary vessels and subclavian artery. The probe is moved distally and laterally to the second and third rib space to identify the pectoralis major. A 20G, 100 mm echogenic needle is inserted between the pectoralis muscles; 15 mL of local anesthetic (LA) is administered in 5 cc increments. The probe is then shifted distally and laterally to the third and fourth rib space. The fascial plane between the pectoralis minor and serratus anterior muscles is identified , and 10 mL of LA is injected in 5 cc increments. For the SAPB, the probe is placed on the midaxillary line at the fifth rib level to visualize the serratus anterior and latissimus dorsi. A 22G spinal needle is inserted in-plane at a 45° angle toward the fifth rib. Saline (0.5-1 mL) is injected to open the plane, and 15 mL of 0.25% LA is administered",[18],"Procedure: Ultrasound guided Pectoserratus Block",{"label":20,"type":21,"description":22,"interventionNames":23},"control group","NO_INTERVENTION","the patients of this group received general anesthesia without regional plane block",null,[25,29],{"type":26,"name":9,"description":27,"armGroupLabels":28,"otherNames":23},"PROCEDURE","Ultrasound guided bilevel Erector spinae plane block",[9],{"type":26,"name":30,"description":31,"armGroupLabels":32,"otherNames":23},"Ultrasound guided Pectoserratus Block","ultra sound guided combined Pectoral Nerve (PECS II) Block and Serratus anterior (SAPB) plane block",[15],[34],{"name":35,"affiliation":36,"role":37},"Ayman Sharawy Abdelrahman Aboul Nasr, MD","National Cancer Institute Cairo University","STUDY_DIRECTOR",[39,44],{"name":35,"role":40,"phone":41,"phoneExt":42,"email":43},"CONTACT","01282649008","0020","ayman.sharawy@nci.cu.edu.eg",{"name":45,"role":40,"phone":46,"phoneExt":23,"email":47},"Yousr Farag Abdelhamid, MSc","01095444856","dr.yousrfarag@gmail.com",[49],{"facility":50,"status":51,"city":52,"state":23,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"National Cancer Institute - Cairo University","RECRUITING","Cairo","11796","Egypt","EG",{"type":57,"coordinates":58},"Point",[59,60],31.24967,30.06263,{"lat":60,"lon":59},[63,66],{"name":64,"role":40,"phone":65,"phoneExt":42,"email":43},"Ayman Sharawy AbdelRahman Aboul Nasr, MD","+201282649008",{"name":45,"role":40,"phone":46,"phoneExt":23,"email":47},{"type":68,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Ayman Sharawy Abdel Rahman Aboul Nasr","Principal investigator","100642606","bilevel-erector-spinae-plane-block-versus-pectoserratus-block-for-analgesia-in-modified-radical-mastectomy-100642606",false,"NCT07650305","Bilevel Erector Spinae Plane Block Versus Pectoserratus Block for Analgesia in Modified Radical Mastectomy","Bilevel Erector Spinae Plane Block Versus Pecto-serratus Block for Analgesia in Modified Radical Mastectomy in Cancer Surgery","Inclusion Criteria:\n\n1. Breast cancer female patients.\n2. ASA class II and III.\n3. Age ≥ 18 and ≤ 65 Years.\n4. Body mass index (BMI): \\> 20 kg\u002Fm2 and \\\u003C 35 kg\u002Fm2.\n5. Type of surgery; elective breast cancer surgery modified radical mastectomy combined with axillary dissection.\n\nExclusion Criteria:\n\n1. Patient refusal.\n2. Age \\\u003C18 years or \\>65 years.\n3. BMI \\\u003C20 kg\u002Fm2 and \\>35 kg\u002Fm2.\n4. Major medical conditions.\n5. Pregnancy or lactation.","FEMALE","18 Years","65 Years",{"count":82,"type":83},60,"ESTIMATED","INTERVENTIONAL",[86],"NA","Breast cancer remains the most frequently diagnosed cancer and a major cause of cancer-related mortality among women worldwide. Modified radical mastectomy (MRM), a common surgical procedure for breast cancer, is associated with significant postoperative pain, which may delay recovery and contribute to the development of chronic postmastectomy pain syndrome (PMPS). To address this, regional anesthesia techniques have been increasingly incorporated into multimodal analgesia strategies to reduce opioid consumption and enhance patient outcomes. Interfascial plane blocks, in particular, offer safe and effective analgesia under ultrasound guidance. The erector spinae plane block (ESPB), first described in 2016, involves injection of local anesthetic deep to the erector spinae muscle and may spread to the paravertebral space, providing both somatic and visceral analgesia. A bilevel approach may enhance dermatomal coverage. Meanwhile, the pectoserratus plane block (PSPB), which combines PECS II and serratus anterior blocks, targets nerves of the anterior and lateral chest wall and has shown efficacy in breast surgery",[89],"Breast Cancer",[91,92,93],"erector spinae plane block","pectoserratus block","ultrasound","2026-06-10",{"date":96,"type":97},"2026-06-16","ACTUAL",{"date":99,"type":97},"2026-05-01",{"date":101,"type":83},"2026-08-02",{"name":5,"class":6},1]