[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100497715":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":44,"responsibleParty":70,"collaborators":25,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":25,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":95,"overallStatus":47,"whyStopped":25,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"University Hospital of Mont-Godinne","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Bimanual Circuit version 1","EXPERIMENTAL","Training on the REAplan® robot with a serious game based on proximal motor skill learning (bim-MSkL) with the bimanual version 1 of the Circuit task and training on the Dextrain Manipulandum with a serious game based on distal bim-MSkL",[13,14],"Device: REAplan®","Device: Dextrain Manipulandum®",{"label":16,"type":10,"description":17,"interventionNames":18},"Bimanual Circuit version 2","Training on the REAplan® robot with a serious game based on motor skill learning (MSkL) with bimanual version 2 of the Circuit task and training on the Dextrain Manipulandum with a serious game based on distal bim-MSkL",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","REAplan®","motor skill learning with the REAplan® rehabilitation robot, to be performed with both arms",[9,16],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Dextrain Manipulandum®","motor skill learning with the Dextrain Manipulandum® dexterity tool to be performed with both hands",[9,16],[31],{"name":32,"affiliation":33,"role":34},"Yves Vandermeeren, MD, PhD","UCLouvain IONS","PRINCIPAL_INVESTIGATOR",[36,40],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},"CONTACT","+32 81 42 33 21","yves.vandermeeren@uclouvain.be",{"name":41,"role":37,"phone":42,"phoneExt":25,"email":43},"Coralie van Ravestyn, MSc","+32 81 34 06","coralie.vanravestyn@uclouvain.be",[45,63],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"CHU UCL Namur","RECRUITING","Yvoir","Namur","5530","Belgium","BE",{"type":54,"coordinates":55},"Point",[56,57],4.88059,50.3279,{"lat":57,"lon":56},[60],{"name":61,"role":37,"phone":62,"phoneExt":25,"email":43},"Coralie van Ravestyn","+3281423406",{"facility":64,"status":47,"city":48,"state":25,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":65,"geoPoint":67,"contacts":68},"University Hospital CHU Dinant Godinne UCL",{"type":54,"coordinates":66},[56,57],{"lat":57,"lon":56},[69],{"name":32,"role":37,"phone":25,"phoneExt":25,"email":39},{"type":34,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Pr Yves Vandermeeren, MD, PhD","Principal Investigator","100497715","bimanual-motor-skill-learning-in-acute-stroke-100497715",false,"NCT05760846","Bimanual Motor Skill Learning in Acute Stroke","Exploring the Neural Substrates of Proximal and Distal Bimanual Motor Skill Learning Through Robotics and Multimodal Brain Imaging","MLAS4","ACUTE STROKE PATIENTS:\n\nInclusion Criteria:\n\n* acute stroke (\\\u003C 21 days)\n* aged 18-90 years\n* with a demonstrated stroke (ischemic or hemorrhagic) lesion on brain imaging\n\nExclusion Criteria:\n\n* \" classical \" contre-indication to MRI (non-MR-compatible pacemaker, pregnancy, non-MR-compatible implanted devices, claustrophobia, etc ...)\n* difficulty in understanding or executing commands\n* drug\u002Falcohol abuse\n* severe aphasia \u002F cognitive deficits interfering with study\n* inability to complete the tasks (i.e. full paralysis of the arm)\n* multiple strokes \u002F dementia \u002F psychiatric condition\n\nHEALTHY INDIVIDUALS:\n\nInclusion Criteria:\n\n• 18-90 years\n\nExclusion Criteria:\n\n* medical history with a previous stroke \u002F relevant neurological deficit\n* drug\u002Falcohol abuse\n* psychiatric condition\u002F dementia",true,"ALL","18 Years","90 Years",{"count":86,"type":87},160,"ESTIMATED","INTERVENTIONAL",[90],"NA","The subacute phase of stroke provides a window into how a lesion perturbs sensorimotor functions prior to reorganisation driven by plasticity and neurorehabilitation. The recovery from motor impairment has been extensively studied, but it is currently unknown whether motor skill learning (MSkL) is enhanced or impaired during acute stroke, especially bimanual motor skill learning (bim-MSkL), which likely requires more motor-attentional-cognitive resources than unimanual MSkL.\n\nThe goals of this project are: to determine the neural substrates critical to achieve proximal and distal bimanual motor skill learning (bim-MSkL) by specifying whether (sub)acute stroke to different brain areas (cortical and subcortical) induce specific deficits in bimanual and\u002For distal bim-MSkL, which behavioral components are involved in bim-MSkL, and whether damage to the motor, sensory and inter-hemispheric pathways specifically impairs proximal and\u002For distal bim-MSkL.",[93,94],"Stroke, Acute","Stroke, Subacute",[96,97,98,99,100],"Motor Skill Learning","Upper limb","Acute stroke","Rehabilitation","Subacute stroke","2024-12-10",{"date":103,"type":104},"2024-12-16","ACTUAL",{"date":106,"type":104},"2023-04-17",{"date":108,"type":87},"2028-10",{"name":5,"class":6},2]