[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635000":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":18,"centralContacts":22,"locations":27,"responsibleParty":57,"collaborators":10,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":10,"enrollmentInfo":68,"targetDuration":10,"studyType":71,"phases":10,"briefSummary":72,"conditions":73,"keywords":10,"overallStatus":77,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Centre Hospitalier Universitaire de Nīmes","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"Patients with infected central venous catheters",null,[12],"Other: Microbial analysis of catheter biofilm",[14],{"type":6,"name":15,"description":16,"armGroupLabels":17,"otherNames":10},"Microbial analysis of catheter biofilm","Identification and sampling of the catheter, standard microbiological analysis, inclusion and transfer (INSERM platform), biofilm analysis, and collection of associated data (clinical, biological and related to the catheter).",[9],[19],{"name":20,"affiliation":5,"role":21},"Nicolas Boulet","PRINCIPAL_INVESTIGATOR",[23],{"name":20,"role":24,"phone":25,"phoneExt":10,"email":26},"CONTACT","+334 66 68 33 31","nicolas.boulet@chu-nimes.fr",[28,44],{"facility":29,"status":10,"city":30,"state":10,"zip":10,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"CH d'Alès","Alès","France","FR",{"type":34,"coordinates":35},"Point",[36,37],4.08082,44.12489,{"lat":37,"lon":36},[40],{"name":41,"role":24,"phone":42,"phoneExt":10,"email":43},"Lucile Cadot","04 66 78 31 42","dr.cadot@ch-ales.fr",{"facility":45,"status":10,"city":46,"state":10,"zip":10,"country":31,"countryCode":32,"cosmosGeoPoint":47,"geoPoint":51,"contacts":52},"CHU de Nîmes","Nîmes",{"type":34,"coordinates":48},[49,50],4.35788,43.83665,{"lat":50,"lon":49},[53],{"name":54,"role":24,"phone":55,"phoneExt":10,"email":56},"Anissa Megzari","04.66.68.42.36","drc@chu-nimes.fr",{"type":58,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100635000","biofilm-induced-antimicrobial-resistance-risk-eradication-in-critical-care-central-venous-catheters-100635000",false,"NCT07546994","Biofilm-induced Antimicrobial Resistance RIsk ERadication in Critical Care Central Venous Catheters","BARRIER","Inclusion Criteria:\n\n* Central venous catheters (conventional central venous lines, dialysis catheters, PICC lines) showing positive microbiological culture taken from adult patients in the critical care units (intensive care units, post-operative intensive care units and post-resuscitation intensive care units)\n* Patient consent is free, informed, and non-opposition, provided after delivery of an information letter and oral explanation.\n\nExclusion Criteria:\n\n* None","ALL","18 Years",{"count":69,"type":70},150,"ESTIMATED","OBSERVATIONAL","Central venous catheter (CVC) infections are a frequent and serious nosocomial complication in critical care, leading to increased morbidity, mortality, and costs. The pathophysiology of these infections relies on the formation of a biofilm, an organized microbial structure that confers exceptional tolerance to anti-infectives and the immune system. However, data concerning the characteristics of the in vivo biofilm (kinetics, composition, endo- vs. extraluminal organization) on central venous catheters in intensive care patients are very limited, hindering the development of effective and targeted prevention strategies.\n\nThe main aim of this study is to quantify the density and describe the spatial distribution (extra- and intraluminal compartments) of the biofilm on infected or colonized central venous catheters, prospectively collected from patients in the critical care units.",[74,75,76],"Catheter-Related Infections","Biofilms","Infection Prevention","NOT_YET_RECRUITING","2026-04-16",{"date":80,"type":81},"2026-04-23","ACTUAL",{"date":83,"type":70},"2026-04",{"date":85,"type":70},"2028-04",{"name":5,"class":6},2]