[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606274":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":34,"responsibleParty":60,"collaborators":62,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":18,"enrollmentInfo":74,"targetDuration":18,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":37,"whyStopped":18,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Mid and South Essex NHS Foundation Trust","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"BIA-guided group","ACTIVE_COMPARATOR","Bioimpedance Analysis (BIA) will be performed within 24 hours of admission using the portable Bioscan touch i8 device (Maltron International, Essex, UK). The clinical team managing the patient will conduct serial BIA measurements and record the estimated dry weight in the patient's medical record during admission. Diuretic therapy and other fluid management strategies will be adjusted based on the BIA estimated dry weight throughout the hospital episode, in addition to standard clinical assessments, including physical examination and conventional diagnostic tools (e.g., chest X-ray, echocardiography), to achieve euvolaemia.",[13],"Device: Bioimpedance analysis",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard Care Group","NO_INTERVENTION","A member of the research team not involved in the patients care will conduct the BIA and will record the estimated dry weight in the research records at enrolment (BIA 1) and at discharge (BIA 2). These results would be blinded to clinicians managing the patient, who will aim to achieve euvolemia based on usual clinical judgement, discretion and conventional diagnostic tools.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DEVICE","Bioimpedance analysis","Bioimpedance analysis involves electrodes attached to the patient's limbs which measures the resistance in the body to an imperceptible high-frequency, low-amplitude alternating electrical current. BIA measurements will include total body water (TBW), intracellular water (ICW), extracellular water (ECW), and the derived parameter \"dry weight\". Results are available at the bedside within 2 minutes.",[9],[26,31],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"Henry Oluwasefunmi Savage, MD FRCP","CONTACT","+44 01268524900","henry.savage@nhs.net",{"name":32,"role":28,"phone":29,"phoneExt":18,"email":33},"Archana Ganapathy, MRCP","archana.ganapathy@nhs.net",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Basildon University Hospital","RECRUITING","Basildon","Essex","SS16 5NL","United Kingdom","UK",{"type":44,"coordinates":45},"Point",[46,47],0.45782,51.56844,{"lat":47,"lon":46},[50,53,55,58],{"name":51,"role":28,"phone":29,"phoneExt":18,"email":52},"Georgina Beetar","georgina.beetar@nhs.net",{"name":27,"role":54,"phone":18,"phoneExt":18,"email":18},"PRINCIPAL_INVESTIGATOR",{"name":56,"role":57,"phone":18,"phoneExt":18,"email":18},"Jason Dungu, PhD FRCP","SUB_INVESTIGATOR",{"name":59,"role":57,"phone":18,"phoneExt":18,"email":18},"Archana Ganapathy, MBBS MRCP",{"type":61,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[63],{"name":64,"class":6},"Anglia Ruskin University","100606274","bioimpedance-integration-for-optimized-fluid-management-in-decompensated-heart-failure-100606274",false,"NCT07173426","Bioimpedance Integration for Optimized Fluid Management in Decompensated Heart Failure","BIO-HF","Inclusion Criteria:\n\n1. Age \\>18 years\n2. Patients with hospitalised with a decompensated episode of Heart Failure regardless of Ejection Fraction\n3. Able and willing to consent.\n\nExclusion Criteria:\n\n1. Patients on a palliative care pathway and\u002For estimated life expectancy \\\u003C3 months\n2. Patients admitted to ITU\u002F on intensive care support.\n3. Patients currently taking part in any trials investigating new heart failure drug or interventional treatment.\n4. Patients requiring Renal Replacement Therapy.\n5. Patients unable or unwilling to give consent.","ALL","18 Years",{"count":75,"type":76},255,"ESTIMATED","INTERVENTIONAL",[79],"NA","The goal of this clinical trial is to test whether using Bioimpedance Analysis (BIA) can help manage fluid levels in patients with heart failure who are admitted to the hospital with worsening symptoms. The main questions it aims to answer are:\n\n1\\. Does BIA-guided fluid management reduce the need for extra treatment (in the form of diuretics which helps remove excess fluid from the body) or re-hospitalization for heart failure within 90 days after discharge?\n\nResearchers will compare a group receiving BIA-guided treatment to a standard care group to see if BIA provides better results in managing fluid levels.\n\nParticipants will be randomly assigned to one of two groups:\n\nBIA-Guided Treatment Group: Have BIA measurements done within 24 hours of admission and throughout their hospital stay to guide diuretic treatment.\n\nStandard Care Group: Have BIA measurements taken at admission and discharge, but the results will not be shared with the clinical team, who will manage fluid levels as usual.\n\nAll patients will attend a follow-up visit in 2-4 weeks after discharge where the patient will undergo standard health checks, blood tests, and a questionnaire about how heart failure affects their quality of life.\n\nThe investigators will then compare both groups for the primary outcome measure, which is the rates of rehospitalisation or need for additional decongestive treatment, within 90 days of discharge from hospital.",[82,83],"Heart Failure","Decompensated Heart Failure",[85,83,86],"Bioimpedance Analysis","Fluid Assessment","2025-09-12",{"date":89,"type":90},"2025-09-15","ACTUAL",{"date":92,"type":90},"2024-12-30",{"date":94,"type":76},"2026-12-01",{"name":5,"class":6},1]