[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100054301":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":10,"responsibleParty":22,"collaborators":26,"id":30,"slug":31,"hasResults":32,"nctId":33,"briefTitle":34,"officialTitle":35,"acronym":36,"eligibilityCriteria":37,"healthyVolunteers":32,"sex":38,"minAge":39,"maxAge":40,"enrollmentInfo":41,"targetDuration":10,"studyType":44,"phases":10,"briefSummary":45,"conditions":46,"keywords":48,"overallStatus":53,"whyStopped":10,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":10},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Colorectal Surgery Patients",null,"Patients undergoing colorectal surgery",[13,18],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Demario S Overstreet, Ph.D.","CONTACT","13344130112","demariooverstreet@uabmc.edu",{"name":19,"role":15,"phone":20,"phoneExt":10,"email":21},"Tammie Quinn, B.A.","205-934-8743","tquinn@uab.edu",{"type":23,"investigatorFullName":24,"investigatorTitle":25,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Demario Overstreet","Assistant Professor of Surgery",[27],{"name":28,"class":29},"National Institute of General Medical Sciences (NIGMS)","NIH","100054301","biological-and-clinical-underpinnings-of-postoperative-pain---colorectal-surgery-100054301",false,"NCT07219160","Biological and Clinical Underpinnings of Postoperative Pain - Colorectal Surgery","Biological and Clinical Underpinnings of Postoperative Pain - Colorectal Surgery (BAC-UPP 2 Study)","BAC-UPP 2","Inclusion Criteria:\n\n* Participants scheduled for colorectal cancer surgery\n* Age between 18-65; 3)\n* Understanding verbal and written English\n\nExclusion Criteria:\n\n* Concurrent medical conditions that could confound the interpretation of the data\n* Human immunodeficiency virus positive diagnosis\n* Cardiovascular or pulmonary disease\n* Systemic rheumatoid disease\n* Uncontrolled hypertension (i.e. SBP\u002FDBP of \\> 150\u002F95\n* Current illness accompanied by fever (body temperature \\>38 °C)\n* Any other chronic pain conditions\n* Conditions resulting in altered nerve sensation\n* Hospitalization due to psychiatric illness within the last 6 months\n* Poorly controlled diabetes\n* History of stroke\n* History of seizures\n* Circulatory disorders such AS Raynauds' disease\n* History of drug or alcohol abuse.","ALL","18 Years","89 Years",{"count":42,"type":43},128,"ESTIMATED","OBSERVATIONAL","Persistent pain after colorectal surgery remains a significant clinical challenge that can delay recovery, reduce quality of life, and increase long-term healthcare burden. The goal of this study is to gain a deeper understanding of the biological and clinical factors that influence pain severity after colorectal surgery and contribute to the transition from acute to chronic postoperative pain. Guided by a biopsychosocial framework, this research will address the following aims:\n\n1. The investigators will use standardized experimental pain testing before surgery to evaluate how patients respond to different types of controlled sensory stimuli. These responses may help predict who is more likely to experience severe or prolonged pain after surgery.\n2. The investigators will analyze blood samples collected before and after surgery to measure markers of inflammation and other biological responses. These data will help us explore how the body's immune and hormonal systems relate to pain severity in both the short- and longer-term recovery phases.\n3. The investigators will assess psychological and clinical factors, such as emotional health, coping style, household income, and life stressors, to understand how they contribute to patients' pain experiences throughout recovery.\n4. The investigators will examine whether routinely collected demographic and clinical characteristics can help identify patients at greater risk of experiencing higher levels of pain after surgery. This approach will allow us to better understand which patients may benefit from more tailored perioperative pain management strategies.",[47],"Colorectal Surgery",[49,50,51,52],"colorectal surgery","nociception","acute pain","chronic pain","NOT_YET_RECRUITING","2026-07-10",{"date":56,"type":57},"2026-07-13","ACTUAL",{"date":59,"type":43},"2026-09-01",{"date":61,"type":43},"2030-08",{"name":5,"class":6}]