[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100524170":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":17,"responsibleParty":48,"collaborators":10,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":10,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":10,"enrollmentInfo":59,"targetDuration":62,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":10,"overallStatus":20,"whyStopped":10,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Intermountain Health Care, Inc.","OTHER",[8,12,14],{"label":9,"type":10,"description":11,"interventionNames":10},"Retrospective Cohort Aim 1",null,"Aims 1 and 2 are retrospective and will be conducted with the same dataset, just at two different time points (at diagnosis of CTEPH and after PTE surgery). For simplicity, aims 1 and 2 will be combined into one section throughout the protocol.",{"label":13,"type":10,"description":11,"interventionNames":10},"Retrospective Cohort Aim 2",{"label":15,"type":10,"description":16,"interventionNames":10},"Prospective Cohort Aim 3","Aim 3 is prospective and will enroll a distinct set of patients from Aim 1 and 2.",[18],{"facility":19,"status":20,"city":21,"state":22,"zip":23,"country":24,"countryCode":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":32},"Intermountain Medical Center","RECRUITING","Murray","Utah","84107","United States","US",{"type":27,"coordinates":28},"Point",[29,30],-111.88799,40.66689,{"lat":30,"lon":29},[33,38,42,45],{"name":34,"role":35,"phone":36,"phoneExt":10,"email":37},"Valerie Aston","CONTACT","801-507-4606","valerie.aston@imail.org",{"name":39,"role":35,"phone":40,"phoneExt":10,"email":41},"Darrin Applegate","801-507-4814","darrin.applegate@imail.org",{"name":43,"role":44,"phone":10,"phoneExt":10,"email":10},"Meghan Cirulis, MD","PRINCIPAL_INVESTIGATOR",{"name":46,"role":47,"phone":10,"phoneExt":10,"email":10},"Mark Dodson, MD","SUB_INVESTIGATOR",{"type":49,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100524170","biological-sex-and-cteph-related-rv-dysfunction-and-recovery-biosphere-100524170",false,"NCT06105242","Biological Sex and CTEPH-related RV Dysfunction and Recovery (BIOSPHeRe)","Biological Sex and Sex Hormones Moderate Right Ventricular (RV) Dysfunction and Recovery in Chronic Thromboembolic Pulmonary Hypertension","Inclusion criteria\n\n* Adult (≥18 years old) patients diagnosed with CTEPH per current guideline standard42\n* Subject must have a baseline TTE (within 3 months of diagnosis) with adequate images for RVGLS analysis\n* Subject must have a right heart catheterization (RHC) at the time of diagnosis\n* To be included in the Aim 2 analysis, patients must undergo PTE surgery and have a TTE performed 3-9 months after surgery with adequate images for RVGLS strain analysis\n\nExclusion criteria\n\n* Unclear or mixed PH diagnosis as designated by an expert clinician at Intermountain PH center\n* Any subjects \\\u003C18 years of age\n* Patients diagnosed during pregnancy\n* Patients without a TTE and RHC at time of diagnosis","ALL","18 Years",{"count":60,"type":61},10,"ESTIMATED","6 Months","OBSERVATIONAL","1. To identify biological sex differences in baseline RV function in CTEPH\n2. To identify biological sex differences in recovery of RV function after PTE surgery in CTEPH\n3. To determine if sex hormone levels relate to RV function at CTEPH diagnosis and during recovery after PTE.",[66],"CTEPH","2023-10-23",{"date":69,"type":70},"2023-10-27","ACTUAL",{"date":72,"type":70},"2022-05-30",{"date":74,"type":61},"2026-12-31",{"name":5,"class":6},1]