[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631759":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":23,"locations":32,"responsibleParty":47,"collaborators":10,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":10,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":71,"overallStatus":78,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Kırıkkale University","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"SWEEPS Group",null,"22 participants. Method: Retreatment using SWEEPS activation. Collection of PAE samples.",{"label":13,"type":10,"description":14,"interventionNames":10},"US Group","22 participants. Method: Retreatment using US activation. Collection of PAE samples.",{"label":16,"type":10,"description":17,"interventionNames":10},"CSI Group","22 participants. Method: Retreatment using CSI activation. Collection of PAE samples.",[19],{"name":20,"affiliation":21,"role":22},"Sevda DURUST BARIS, Asst. Prof.","Kirikkale University Faculty of Dentistry","PRINCIPAL_INVESTIGATOR",[24,28],{"name":20,"role":25,"phone":26,"phoneExt":10,"email":27},"CONTACT","+905079396652","s.baris@kku.edu.tr",{"name":29,"role":25,"phone":30,"phoneExt":10,"email":31},"Gamze Ebrar NALBANT, Research Assistant","+905060650480","ebraruzunpinar@gmail.com",[33],{"facility":34,"status":10,"city":35,"state":36,"zip":37,"country":38,"countryCode":10,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Kırıkkale University, Faculty of Dentistry","Kirikkale","Kırıkkale","71100","Turkey (Türkiye)",{"type":40,"coordinates":41},"Point",[42,43],33.50639,39.84528,{"lat":43,"lon":42},[46],{"name":20,"role":25,"phone":26,"phoneExt":10,"email":27},{"type":22,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Sevda Durust Baris","Assistant Professor","100631759","biomarkers-in-apical-periodontitis-100631759",false,"NCT07504861","Biomarkers in Apical Periodontitis","Effects of Different Irrigation Activation Techniques on Pro-inflammatory Cytokine and Proteolytic Enzyme Levels in Teeth With Chronic Apical Periodontitis","Inclusion Criteria:\n\n* Male patients aged 18-35 years.\n* Presence of chronic apical periodontitis in maxillary or mandibular incisors, canines, or single-rooted\u002Fsingle-channeled premolars.\n* History of root canal treatment performed at least 4 years ago.\n* Presence of a periapical lesion smaller than 1 cm.\n* Periapical Index (PAI) score of 3 or 4 according to Orstavik classification.\n\nExclusion Criteria:\n\n* Need for antibiotic prophylaxis\n* Diabetes\n* Hematological disorders\n* Use of antibiotics or anti-inflammatory drugs within the last month.\n* Excessive plaque and tartar\n* Gum redness or bleeding\n* Severe gingivitis\n* Widespread periodontitis\n* Periodontal pocket depths exceeding 3 mm.\n* Presence of sinus fistula (bleeding).\n* Presence of internal or external root resorption.\n* Pain on palpation of teeth\n* Swelling\n* Pregnancy during treatment.",true,"MALE","18 Years","35 Years",{"count":62,"type":63},66,"ESTIMATED","OBSERVATIONAL","Aim: To evaluate the effects of three different irrigation activation techniques-conventional syringe irrigation (CSI), ultrasonic irrigation (UI), and SWEEPS (Shock Wave Enhanced Emission Photoacoustic Streaming)-on the levels of proinflammatory cytokines (Tumor Necrosis Factor Alpha (TNF-α), interleukin-1beta (IL-1β)) and proteolytic enzymes matrix metalloproteinase-9 (MMP-9) in teeth with chronic apical periodontitis.\n\nMethodology: Sixty-six male patients (aged 18-35) with single-rooted teeth, previous root canal treatment (at least 4 years ago), and periapical lesions (\\\u003C1 cm, PAI score 3 or 4) were included. Sample size was determined by G\\*Power (Power=0.90, α=0.05). Following local anesthesia and rubber dam isolation, endodontic access was performed under a dental operating microscope. After removing old filling material and completing root canal preparation with Reciproc R25\u002FR50 files, patients were randomly assigned into three groups (n=22 each): (1) CSI (30G needle), (2) UI (EMS miniPiezon), and (3) SWEEPS (Er:YAG laser, 2940 nm). Periapical exudate samples were collected using sterile paper points (2 mm beyond the apex for 60s) at the first visit (pre-treatment) and the second visit (one week post-medication with calcium hydroxide). Samples were analyzed via ELISA for TNF-α, IL-1β, and MMP-9 levels.\n\nStatistical Analysis: Data were analyzed using IBM SPSS 20. Percent changes in biomarker levels were evaluated using the Kruskal-Wallis test for inter-group comparisons and the Wilcoxon test for intra-group (pre- vs. post-treatment) comparisons. Linear regression was used to identify effective factors (group, age, gender, tooth type). Significance was set at (p \\\u003C 0.05).\n\nKeywords: Apical periodontitis, SWEEPS, Ultrasonic activation, Cytokines, MMP-9, Endodontics.",[67,68,69,70],"Apical Periodontitis","Retreatment","Biomarkers","Cytokine",[72,73,74,75,76,77],"Apical periodontitis","SWEEPS","Ultrasonic activation","Cytokines","MMP-9","Endodontics","NOT_YET_RECRUITING","2026-03-26",{"date":81,"type":82},"2026-04-01","ACTUAL",{"date":84,"type":63},"2026-03-30",{"date":86,"type":63},"2026-09-28",{"name":5,"class":6},1]