[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100247282":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":22,"locations":28,"responsibleParty":50,"collaborators":52,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":10,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":10,"studyType":73,"phases":10,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"University of Florida","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Affected with Friedreich's ataxia",null,"Friedreich's ataxia patients aged 6 to 70 (inclusive). Assessments will include collection of genetic mutation reports, cardiac and exercise MRI, echocardiogram, the Friedreich's Ataxia Rating Scale (FARS), exercise testing with a recombinant bike and\u002For hand ergometer, pulmonary function testing, and gait analysis. Optional labs include a blood draw, skin biopsy, and\u002For muscle biopsy.",{"label":13,"type":10,"description":14,"interventionNames":10},"Healthy controls","Health controls aged 6 to 70 (inclusive). Assessments will include cardiac and exercise MRI, echocardiogram, the Friedreich's Ataxia Rating Scale (FARS), exercise testing, hand ergometer for exercise testing, pulmonary function testing, gait analysis, and optional blood draws and\u002For muscle\u002Fskin biopsies",{"label":16,"type":10,"description":17,"interventionNames":10},"Carriers of Friedreich's ataxia","An obligate carrier aged 18 to 70 (inclusive) of the abnormal Friedreich's ataxia gene by being a parent of a child with Friedreich's ataxia. No assessments are to be conducted. Optional labs include a blood draw, skin biopsy, and\u002For muscle biopsy.",[19],{"name":20,"affiliation":5,"role":21},"Manuela Corti, PT, PhD","PRINCIPAL_INVESTIGATOR",[23],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Mackenzi Coker, M.S.CCC-SLP","CONTACT","352-294-8754","mcoker@peds.ufl.edu",[29],{"facility":5,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"RECRUITING","Gainesville","Florida","32610","United States","US",{"type":37,"coordinates":38},"Point",[39,40],-82.32483,29.65163,{"lat":40,"lon":39},[43,46,47],{"name":44,"role":25,"phone":26,"phoneExt":10,"email":45},"Mackenzi Coker, MS, CCC-SLP","mcoker@ufl.edu",{"name":20,"role":21,"phone":10,"phoneExt":10,"email":10},{"name":48,"role":49,"phone":10,"phoneExt":10,"email":10},"Sub Subramony, MD","SUB_INVESTIGATOR",{"type":51,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[53,55,58],{"name":54,"class":6},"Children's Miracle Network",{"name":56,"class":57},"National Institutes of Health (NIH)","NIH",{"name":59,"class":57},"National Center for Advancing Translational Sciences (NCATS)","100247282","biomarkers-in-friedreichs-ataxia-100247282",false,"NCT02497534","Biomarkers in Friedreich's Ataxia","Inclusion Criteria:\n\n* Genetic diagnosis of Friedreich's ataxia by DNA sequencing, mutational analysis or protein assay OR be a healthy subject with no evidence of a neuromuscular disorder\n* Between the ages of 6 and 70 (inclusive)\n* Are able to tolerate metabolic exercise testing\n* Are stable on cardiac medication regimen for 3 months prior to screening\n\nExclusion Criteria:\n\n* Presence of unstable heart disease\n* Receipt of cardiac transplant\n* Any concurrent medical condition which, in the opinion of the investigators, would make the subject unsuitable for the study",true,"ALL","6 Years","70 Years",{"count":71,"type":72},203,"ESTIMATED","OBSERVATIONAL","The purpose of this project is to characterize measures of cardiac performance and neuromuscular physiology in FA patients using novel techniques, including echocardiography and magnetic resonance imaging (MRI), metabolic exercise testing, and neurophysiological outcomes.",[76],"Friedreich's Ataxia",[78,79],"ataxia","neuromuscular","2025-09-17",{"date":82,"type":83},"2025-09-23","ACTUAL",{"date":85,"type":10},"2015-09",{"date":87,"type":72},"2030-06-03",{"name":5,"class":6},1]