[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636799":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":21,"centralContacts":25,"locations":35,"responsibleParty":51,"collaborators":53,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":10,"studyType":83,"phases":10,"briefSummary":84,"conditions":85,"keywords":89,"overallStatus":93,"whyStopped":10,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"University of Exeter","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"OS1 0-4",null,"Newborns and infants up to 12 months of age",{"label":13,"type":10,"description":14,"interventionNames":10},"OS1 5-10","Children aged between 5 and 10 years old",{"label":16,"type":10,"description":17,"interventionNames":10},"OS2 11-18","Adolescents aged between 11 and 18 years old",{"label":19,"type":10,"description":20,"interventionNames":10},"OS2 19-25","Young adults aged between 19 and 25 years old",[22],{"name":23,"affiliation":5,"role":24},"Christopher Fox, MD","PRINCIPAL_INVESTIGATOR",[26,32],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},"Kim Chapman","CONTACT","+44(0) 1326 370400","2969","k.chapman3@exeter.ac.uk",{"name":33,"role":28,"phone":29,"phoneExt":30,"email":34},"Talita Dias da Silva Magalhaes, PhD","T.Dias.Magalhaes@exeter.ac.uk",[36],{"facility":5,"status":10,"city":37,"state":10,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Exeter","EX4 4QJ","United Kingdom","UK",{"type":42,"coordinates":43},"Point",[44,45],-3.52751,50.7236,{"lat":45,"lon":44},[48,49],{"name":27,"role":28,"phone":10,"phoneExt":10,"email":31},{"name":50,"role":24,"phone":10,"phoneExt":10,"email":10},"Helen Dawes",{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[54,56,58,60,62,64,66],{"name":55,"class":6},"University of Southampton",{"name":57,"class":6},"University of Dublin, Trinity College",{"name":59,"class":6},"Carol Davila University of Medicine and Pharmacy",{"name":61,"class":6},"Jimma University",{"name":63,"class":6},"FUNDACION PARA LA INVESTIGACION HOSPITAL CLINICO SAN CARLOS",{"name":65,"class":6},"International Centre for Diarrhoeal Disease Research, Bangladesh",{"name":67,"class":6},"University of Bari Aldo Moro","100636799","biomarkers-of-asdadhd-and-factors-affecting-anxiety-and-depression-in-children-and-young-adults-100636799",false,"NCT07570381","Biomarkers of ASD\u002FADHD and Factors Affecting Anxiety and Depression in Children and Young Adults","Biomarker Discovery for Predicting Autism Spectrum Disorder and Attention\u002FHyperactivity Disorders, and Identification of Environmental Factors Influencing Anxiety and Depression in Children, Adolescents, and Young Adults","PUREMIND-OS","OS1 Inclusion Criteria:\n\n* Infants born very preterm (\\\u003C32 weeks) or extremely preterm (\\\u003C28 weeks); or\n* Term-born infants with documented perinatal asphyxia and hypoxic-ischaemic encephalopathy (HIE); or\n* Term-born infants with no risk factors (comparison group).\n* Must be ≤12 months corrected age at enrolment.\n\nOS1 Exclusion Criteria:\n\n* Syndromic, chromosomal, or known genetic conditions.\n* Motor impairments that would prevent participation in psychometric or neurophysiology assessments.\n\nOS2 Inclusion Criteria:\n\n* Individuals aged 5-25 years.\n* Clinical diagnosis of ASD, ADHD, or Developmental Coordination Disorder (DCD).\n* Able to participate in scheduled assessments.\n\nOS2 Exclusion Criteria:\n\n* Severe motor impairments that limit psychometric assessment.\n* Diagnosis of schizophrenia, due to confounding neurocognitive effects.",true,"ALL","6 Months","25 Years",{"count":81,"type":82},800,"ESTIMATED","OBSERVATIONAL","The PUREMIND OS1\u002FOS2 study is a multinational, prospective, longitudinal observational study designed to identify early neurophysiological, biological, environmental, and psychosocial markers associated with neurodevelopmental and mental health conditions from infancy through young adulthood.\n\nObservational Study 1 (OS1) follows infants and toddlers at high risk for Autism Spectrum Disorder (ASD) and Attention-Deficit\u002FHyperactivity Disorder (ADHD) to discover biomarkers predictive of later clinical diagnosis, using EEG, fNIRS, psychometric assessments, and biological samples.\n\nObservational Study 2 (OS2) includes children, adolescents, and young adults with ASD, ADHD, or Developmental Coordination Disorder (DCD) to identify environmental and biological factors causally linked to anxiety and depression symptoms, and to support the development of personalised criteria for evidence-based interventions.\n\nApproximately 800 participants will be recruited across 10 international clinical sites. The study aims to generate multi-domain data to support predictive modelling and inform future personalised mental-health prevention strategies across childhood and young adulthood.",[86,87,88],"ADHD - Attention Deficit Disorder With Hyperactivity","Autism Spectrum Disorder (ASD)","Developmental Coordination Disorder (DCD)",[90,91,92],"Attention Deficit Disorder with Hyperactivity","Autism spectrum disorder","Developmental Coordination Disorder","NOT_YET_RECRUITING","2026-04-29",{"date":96,"type":97},"2026-05-06","ACTUAL",{"date":99,"type":82},"2026-08-01",{"date":101,"type":82},"2028-12-31",{"name":5,"class":6},1]