[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622310":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":22,"locations":28,"responsibleParty":42,"collaborators":44,"id":91,"slug":92,"hasResults":93,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":99,"sex":100,"minAge":10,"maxAge":101,"enrollmentInfo":102,"targetDuration":10,"studyType":105,"phases":10,"briefSummary":106,"conditions":107,"keywords":111,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":127},{"fullName":5,"class":6},"Uppsala University","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Group A - Radiation",null,"Children diagnosed with primary brain tumors who are treated with surgery and radiation therapy, and\u002For other cancer treatment (n=160).",{"label":13,"type":10,"description":14,"interventionNames":10},"Group B - Radiation-naive","Children diagnosed with primary brain tumors who are treated with surgery and\u002For other cancer treatment, but not radiation therapy (n=200).",{"label":16,"type":10,"description":17,"interventionNames":10},"Group C - Healthy Controls","Healthy children without brain tumors (n=200).",[19],{"name":20,"affiliation":5,"role":21},"Arja Harila, MD, PhD","PRINCIPAL_INVESTIGATOR",[23],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Christoffer Ehrstedt, MD, PhD","CONTACT","0046-(0)18-611-0114","christoffer.ehrstedt@uu.se",[29],{"facility":5,"status":30,"city":31,"state":10,"zip":10,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"RECRUITING","Uppsala","Sweden","SE",{"type":35,"coordinates":36},"Point",[37,38],17.63889,59.85882,{"lat":38,"lon":37},[41],{"name":24,"role":25,"phone":10,"phoneExt":10,"email":27},{"type":43,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[45,48,50,52,54,56,58,60,63,65,67,69,71,73,75,77,79,81,83,85,87,89],{"name":46,"class":47},"Region Blekinge","UNKNOWN",{"name":49,"class":47},"Region Dalarna",{"name":51,"class":47},"Region Gotland",{"name":53,"class":6},"Region Gävleborg",{"name":55,"class":47},"Region of Uppsala",{"name":57,"class":6},"Region Halland",{"name":59,"class":6},"Region Jämtland Härjedalen",{"name":61,"class":62},"Region Jönköping County","OTHER_GOV",{"name":64,"class":47},"Region Kalmar län",{"name":66,"class":47},"Region Kronoberg",{"name":68,"class":6},"Region Norrbotten",{"name":70,"class":6},"Region Skane",{"name":72,"class":62},"Region Stockholm",{"name":74,"class":6},"Sormland County Council, Sweden",{"name":76,"class":47},"Region Värmland",{"name":78,"class":62},"Region Västerbotten",{"name":80,"class":47},"Region Västernorrland",{"name":82,"class":6},"Region Västmanland",{"name":84,"class":47},"Region Örebro län",{"name":86,"class":47},"Region Östergotland",{"name":88,"class":6},"Göteborg University",{"name":90,"class":6},"Västra Götalandsregionen","100622310","biomarkers-of-brain-injury-in-children-with-brain-tumors-100622310",false,"NCT07381959","Biomarkers of Brain Injury in Children With Brain Tumors","Biomarkörer för hjärnskada Hos Barn Med hjärntumör","BiomarkCBT","Inclusion Criteria, Group A (treated with radiation):\n\n* Age 0-17 years old, AND\n* Diagnosed with primary brain tumor through surgery, biopsy, or other diagnostic method (e.g., for germinoma) at Uppsala University Hospital or at another university hospital in Sweden, AND\n* Referred for radiotherapy at Skandion Clinic in Uppsala and\u002For at their local hospital (in some cases), with\u002Fwithout the addition of other cancer treatments.\n\nInclusion Criteria, Group B (treated without radiation\u002Fradiation naive):\n\n* Age 0-17 years old, AND\n* Diagnosed with primary brain tumor through surgery, biopsy, or other diagnostic method (e.g., for optic pathway glioma in neurofibromatosis type 1 and germinoma) at Uppsala University Hospital or at another university hospital in Sweden, AND\n* Not referred to radiotherapy and treated with\u002Fwithout the addition of other cancer treatments.\n\nInclusion Criteria, Group C (healthy control group):\n\n* Age 0-17 years old at time of recruitment\n\nExclusion Criteria, Groups A + B:\n\n* Diagnosed with a tumor only in the spinal cord (solitary spinal tumor).\n* Diagnosed with a tumor considered palliative already at diagnosis (e.g., diffuse intrinsic pontine glioma)\n\nExclusion Criteria, Group C:\n\n* Have diagnosis of chronic disease that requires continuous medication.\n\nExclusion Criteria, all groups:\n\n* Unable to provide informed consent due to language difficulties.",true,"ALL","17 Years",{"count":103,"type":104},560,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to identify biomarkers of treatment-induced brain injury in children treated for primary brain tumors. The main question it aims to answer is:\n\nCan investigators identify sensitive plasma biomarker(s) of treatment-induced brain injury in children with primary brain tumors?\n\nResearchers will compare results between different treatment modalities (surgery, chemotherapy, radiation versus radiation-naive) and a healthy age- and sex-matched control population, to identify treatment-specific biomarkers.\n\nParticipants will provide plasma samples at the following time points: before surgery, 1-2 weeks after surgery, as well as at 3-, 6-, 12-, 18-, 24-, and 36 months after surgery. Participants who receive radiation treatment will also provide plasma samples before and during treatment (approximately every 2 weeks). Where possible, plasma samples are also collected before the start of any new treatment (e.g., chemotherapy). Healthy controls will provide samples once.",[108,109,110],"Brain Tumor","Childhood Cancer","Childhood Brain Tumor",[112,113,114,115,116,117],"Radiotherapy","Cranial radiation therapy","Plasma biomarkers","Extracellular vesicles","Proteomics","Childhood brain tumor","2026-01-28",{"date":120,"type":121},"2026-02-02","ACTUAL",{"date":123,"type":121},"2021-08-01",{"date":125,"type":104},"2031-12-31",{"name":5,"class":6},1]