[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100598803":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":27,"locations":36,"responsibleParty":49,"collaborators":10,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":10,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":10,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"NYU Langone Health","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Participants receiving phage therapy",null,"Participants who have a positive match for their Nontuberculous Mycobacterial (NTM) isolate will start on mycobacteriophage treatment. Blood and leftover and\u002For discarded airway samples will be obtained from follow up visits of patients.",[13],"Biological: Bacteriophage Treatment",{"label":15,"type":10,"description":16,"interventionNames":10},"Participants not receiving phage therapy","Participants who don't have a positive match and\u002For do not start on mycobacteriophage treatment. Blood and leftover and\u002For discarded airway samples will be obtained from follow up visits of patients.",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"BIOLOGICAL","Bacteriophage Treatment","Participants who have a positive match for their NTM isolate will start on mycobacteriophage treatment per prescribed treatment regimen.",[9],[24],{"name":25,"affiliation":5,"role":26},"Doreen Addrizzo-Harris, MD, FCCP","PRINCIPAL_INVESTIGATOR",[28,32],{"name":25,"role":29,"phone":30,"phoneExt":10,"email":31},"CONTACT","212-263-6479","Doreen.Addrizzo@nyulangone.org",{"name":33,"role":29,"phone":34,"phoneExt":10,"email":35},"Lira Gutierrez","347-306-4168","Lira.Gutierrez@nyulangone.org",[37],{"facility":5,"status":38,"city":39,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":10},"RECRUITING","New York","10016","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-74.00597,40.71427,{"lat":47,"lon":46},{"type":50,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100598803","biomarkers-of-phage-treatment-response-in-ntm-and-other-infections-100598803",false,"NCT07076238","Biomarkers of Phage Treatment Response in NTM and Other Infections","A Single-Center Observational Biomarker Investigation of Response to Bacteriophage Treatment for Bacterial Infection","Inclusion Criteria:\n\n1. Adults 18 years of age or older\n2. Provision of appropriate written consent\n3. Willingness and ability to participate in study procedures\n4. Diagnosis of bacterial\u002Fmycobacterial infection that meets criteria for treatment (clinical, radiographic, and microbiologic data)\n5. Patients are being considered by clinician for phage therapy as a part of their standard of care\n\nExclusion Criteria:\n\n1. Patients under 18 years of age\n2. Pregnant individuals as this population is not considered for phage treatment due to unknown risks of the treatment\n3. Breastfeeding Individuals who are breastfeeding as this population is not considered for phage treatment due to unknown risk to the infant","ALL","18 Years",{"count":61,"type":62},100,"ESTIMATED","OBSERVATIONAL","This study aims to identify biomarkers associated with response to phage therapy for refractory bacterial infections. This includes mycobacteriophage treatment for patients with nontuberculous mycobacterial infections. Blood and airway samples will be obtained from follow up visits of patients with refractory bacterial infections that are considered for phage therapy. Samples will be compared between those that receive phage therapy and those that did not. Biomarkers will include changes in the airway microbiome, transcriptome, inflammatory cytokines, and development of neutralizing antibody against phages. The primary endpoint is to identify biomarkers associated with clinical and\u002For radiographic improvement and\u002For culture improvement which includes clearing of cultures or decrease in qualitative or resolution of signs and symptoms of infection after at least 6-8 weeks of bacteriophage therapy.",[66],"Nontuberculous Mycobacterial Lung Disease",[68,69],"Bacteriophage therapy","Refractory bacterial infection","2025-10-28",{"date":72,"type":73},"2025-10-30","ACTUAL",{"date":75,"type":73},"2025-06-25",{"date":77,"type":62},"2032-06-25",{"name":5,"class":6},1]