[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100520692":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":26,"locations":32,"responsibleParty":50,"collaborators":52,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":20,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":78,"overallStatus":34,"whyStopped":20,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"VA Office of Research and Development","FED",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Chronic Stroke with lower limb disability","EXPERIMENTAL","The investigators will enroll 55 Veterans with chronic subcortical stroke in the 12-week HIIT intervention, with the expectation that 48 participants (85%) will complete the entire program. In our experience, 65% of participants will respond to the HIIT intervention, resulting in an estimated 31 responders and 17 resistors. Each chronic subcortical stroke participant will be asked to participate in the HIIT study protocol. Classification of resistor or responder: A responder to the 12-week HIIT intervention will be defined as a participant who increases their walking speed to greater than 0.6 m\u002Fs. A resistor to the intervention will be defined as a participant who does not increase their walking speed to greater than 0.6 m\u002Fs.",[13],"Other: High Intensity Interval Training (HIIT)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"OTHER","High Intensity Interval Training (HIIT)","HIIT consists of three weekly 25-60 minute cycling sessions for 12 weeks at the Atlanta VA, administered by a trained exercise physiologist, for a total of 36 HIIT sessions.",[9],null,[22],{"name":23,"affiliation":24,"role":25},"Lisa C Krishnamurthy, PhD","Atlanta VA Medical and Rehab Center, Decatur, GA","PRINCIPAL_INVESTIGATOR",[27],{"name":23,"role":28,"phone":29,"phoneExt":30,"email":31},"CONTACT","(404) 321-6111","6235","Lisa.Krishnamurthy@va.gov",[33],{"facility":24,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"RECRUITING","Decatur","Georgia","30033-4004","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-84.29631,33.77483,{"lat":44,"lon":43},[47,49],{"name":23,"role":28,"phone":48,"phoneExt":30,"email":31},"404-321-6111",{"name":23,"role":25,"phone":20,"phoneExt":20,"email":20},{"type":51,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[53],{"name":54,"class":6},"Atlanta VA Medical Center","100520692","biomarkers-of-reaction-to-hiit-exercise-100520692",false,"NCT06059872","Biomarkers of Reaction To HIIT Exercise","What Makes a Responder, a Responder? Biomarkers to Help Identify Responders and Resistors to High-intensity Interval Training for Lower Extremity Chronic Stroke","BReaTHE","Inclusion Criteria:\n\n* chronic left or right subcortical stroke as defined by 6 months or more after a cardiovascular accident\n* lower extremity motor impairment due to stroke that causes a walking speed of less than 0.6 m\u002Fs during a 10m walk\n* Veteran status\n\nExclusion Criteria:\n\n* MRI contraindications, including implanted cardiac pacemakers and severe claustrophobia\n* any neurodegenerative condition other than stroke that may lead to lower extremity impairment\n* a visual or auditory impairment that may hinder study procedures\n* any medical condition that would preclude participation in a physical exercise intervention program","ALL","18 Years","89 Years",{"count":67,"type":68},55,"ESTIMATED","INTERVENTIONAL",[71],"NA","Stroke survivors with lower limb disability can improve their walking speed with high-intensity interval training (HIIT) rehabilitation therapy. However, some individuals may not respond to HIIT even when fully adherent to the program. To address this, the investigators propose to build a predictive model that identifies if a Veteran with chronic subcortical stroke will improve their walking speed with HIIT by incorporating blood lactate as an early predictor of exercise response, and inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and regional cerebral blood flow (CBF) as predictors of the brain's potential to respond, while also taking into consideration other factors such as comorbidities, demographics, and fitness levels.",[74,75,76,77],"Stroke","Stroke Rehabilitation","Lower Extremity Weakness, Spastic","Walking, Difficulty",[79,80,81,82],"Predictors of Stroke Rehabilitation","Biomarkers of Stroke Rehabilitation","Exercise Intervention","Neuroimaging","2026-03-23",{"date":85,"type":86},"2026-03-27","ACTUAL",{"date":88,"type":86},"2024-01-01",{"date":90,"type":68},"2027-12-01",{"name":5,"class":6},1]