[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624766":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":24,"responsibleParty":41,"collaborators":10,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":10,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":10,"studyType":57,"phases":10,"briefSummary":58,"conditions":59,"keywords":10,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},{"fullName":5,"class":6},"University of Wisconsin, Madison","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Children with perinatal brain injury",null,"Children ages 6 months (may be enrolled prior to 6 months) - 18 months who are diagnosed with 1) hypoxic- ischemic encephalopathy, 2) cerebral palsy, and\u002For 3) were born premature at less than 28 weeks gestational age. (",{"label":13,"type":10,"description":14,"interventionNames":10},"Healthy Children","Children ages 6 months (may be enrolled prior to 6 months) - 18 months of age with no prior history of a brain and\u002For cardiac illness early in life.",[16],{"name":17,"affiliation":5,"role":18},"Melisa Carrasco McCaul, MD, PhD","PRINCIPAL_INVESTIGATOR",[20],{"name":17,"role":21,"phone":22,"phoneExt":10,"email":23},"CONTACT","608-577-2415","carrascomccaul@neurology.wisc.edu",[25],{"facility":26,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"University of Wisconsin Madison University Hospital","RECRUITING","Madison","Wisconsin","53715","United States","US",{"type":34,"coordinates":35},"Point",[36,37],-89.40123,43.07305,{"lat":37,"lon":36},[40],{"name":17,"role":21,"phone":22,"phoneExt":10,"email":23},{"type":42,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100624766","biomarkers-study-in-infants-with-prior-neonatal-brain-injury-100624766",false,"NCT07413900","Biomarkers Study in Infants With Prior Neonatal Brain Injury","Early Biomarkers Study for Prediction of Executive Dysfunction and Cognitive Outcomes Among Infants With Prior Neonatal Brain Injury","Inclusion Criteria:\n\n* Child-parent dyads will be recruited to the study.\n* Children 3-24 months with and without a history of a perinatal brain injury (PBI) will be included in this study.\n* Children with PBIs will include:\n\n  * Children diagnosed during the neonatal period with hypoxic-ischemic encephalopathy,\n  * Children born at a premature gestational age (born at less than 32 weeks gestational age).\n  * Children diagnosed with cerebral palsy\n* Healthy control participants meeting inclusion criteria will include:\n\n  * healthy infants with no prior neurological (brain disorder) history\n* For all parents: the only research inclusion criteria is to be the parent or legal guardian of a newborn with perinatal brain injury or healthy control participant.\n\nExclusion Criteria:\n\n* Healthy infants to be included in the control group will not have:\n\n  * a prior history of brain injury\n  * a diagnosis of cerebral palsy\n  * a history of a neurological disorder\n  * prior admission to the Neonatal Intensive Care Unit (NICU)\n* Children with chromosomal abnormalities, genetic syndromes and major congenital malformations will be excluded from both the patient groups and the control group.\n* Parents will have no exclusionary criteria.",true,"ALL","3 Months","24 Months",{"count":55,"type":56},100,"ESTIMATED","OBSERVATIONAL","This research focuses on the long-term cognitive development of children, including healthy infants and those who had a perinatal brain injury. As part of this research study, children complete in-person games and assessments at UW-Madison University Hospital. Children will also take part in an EEG assessment. Parents will be asked to fill out questionnaires about their child's behavior and stress in the home.",[60,61,62,63],"HIE - Hypoxic - Ischemic Encephalopathy","Perinatal Anoxic-ischemic Brain Injury","Premature Birth","Healthy Participants","2026-02-09",{"date":66,"type":67},"2026-02-17","ACTUAL",{"date":69,"type":67},"2023-03-13",{"date":71,"type":56},"2030-03-15",{"name":5,"class":6},1]