[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552225":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":44,"collaborators":20,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":50,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":20,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":71,"overallStatus":30,"whyStopped":20,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"University of Cyprus","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Smoking Cessation Intervention","EXPERIMENTAL","Participants receive Flexiquit, an avatar-led computerized smoking cessation program. Flexiquit is a self-delivered app providing: motivational interviewing, psychoeducation on addiction\u002Fwithdrawal, cognitive-behavioral strategies for cravings, relapse prevention, stress\u002Femotion regulation skills. Delivered over 6 months starting Day 2 after initial assessments. Adherence monitored. Biochemical verification of abstinence at 3 and 6 months post-quit.",[13],"Behavioral: Flexiquit Computerized Smoking Cessation Program",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Flexiquit Computerized Smoking Cessation Program","Flexiquit is an avatar-led, self-directed computerized program delivering evidence-based techniques to assist with smoking cessation. It includes motivational interviewing, psychoeducation on nicotine addiction, cognitive-behavioral strategies for coping with cravings, relapse prevention, and stress\u002Femotion regulation skills training. Participants receive the program over 6 months and their adherence is monitored. The program provides tailored feedback to support abstinence.",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Panos Zanos, Ph.D.","CONTACT","+35722892243","zanos.panos@ucy.ac.cy",[28],{"facility":29,"status":30,"city":31,"state":20,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Center for Applied Neuroscience","RECRUITING","Nicosia","2100","Cyprus","CY",{"type":36,"coordinates":37},"Point",[38,39],33.35397,35.17284,{"lat":39,"lon":38},[42,43],{"name":23,"role":24,"phone":20,"phoneExt":20,"email":26},{"name":23,"role":24,"phone":20,"phoneExt":20,"email":20},{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Panos Zanos","Assistant Professor of Neuropharmacology","100552225","biopsychosocial-predictors-of-nicotine-relapse-100552225",false,"NCT06470321","Biopsychosocial Predictors of Nicotine Relapse","Identifying Biomarkers of Stress-induced Neurophysiological Changes and Emotion Regulation Deficits to Predict Relapse During Nicotine Abstinence","BioNic","Inclusion Criteria:\n\n* Age 18-60 years\n* Smoking at least 10 cigarettes daily for at least 2 years\n* Intention to quit smoking\n* Medication-free\n\nExclusion Criteria:\n\n* Presence of psychiatric or medical treatment\n* Pregnancy\n* Current unstable medical illness\n* Recent (prior 6 months) drug or alcohol use disorder\n* Major Depression\n* Diagnosis of psychotic disorder","ALL","18 Years","60 Years",{"count":60,"type":61},200,"ESTIMATED","INTERVENTIONAL",[64],"NA","This study aims to investigate the associations between emotion regulation ability, stress-induced neural activity changes, and susceptibility to relapse in smokers attempting to quit. Participants will undergo assessments of emotion regulation, neural activity via quantitative electroencephalography (qEEG), and stress responses before and during a 24-hour nicotine abstinence period. They will then participate in a computerized smoking cessation intervention, and their abstinence status will be monitored for 6 months.",[67,68,69,70],"Smoking","Smoking Cessation","Nicotine Addiction","Tobacco Smoking Behavior",[72,73,74,75,76,77,78],"Nicotine","Relapse","Vulnerability","Biomarkers","EEG","HRV","Stress Reactivity","2024-06-17",{"date":81,"type":82},"2024-06-24","ACTUAL",{"date":84,"type":82},"2022-01-01",{"date":86,"type":61},"2025-05-01",{"name":5,"class":6},1]