[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100473109":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":22,"responsibleParty":43,"collaborators":10,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":10,"eligibilityCriteria":50,"healthyVolunteers":47,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":10,"studyType":57,"phases":10,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":25,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Subjects Treated with Gonadotoxic therapy",null,"Subjects who have planned to undergo OTC for gonadotoxic therapy based on current standard of care.",[13],{"name":14,"affiliation":15,"role":16},"Veronica Gomez-Lobo, M.D.","Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","PRINCIPAL_INVESTIGATOR",[18],{"name":14,"role":19,"phone":20,"phoneExt":10,"email":21},"CONTACT","(301) 435-7567","veronica.gomez-lobo@nih.gov",[23],{"facility":24,"status":25,"city":26,"state":27,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"National Institutes of Health Clinical Center","RECRUITING","Bethesda","Maryland","20892","United States","US",{"type":32,"coordinates":33},"Point",[34,35],-77.10026,38.98067,{"lat":35,"lon":34},[38],{"name":39,"role":19,"phone":40,"phoneExt":41,"email":42},"For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)","800-411-1222","TTY dial 711","ccopr@nih.gov",{"type":44,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100473109","biorepository-in-participants-who-undergo-otc-for-gonadotoxic-therapy-100473109",false,"NCT05440617","Biorepository in Participants Who Undergo OTC for Gonadotoxic Therapy","* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Provision of signed and dated informed consent\u002Fassent form.\n* Stated willingness to comply with all study procedures and availability for the duration of the study.\n* Subjects who have planned to undergo OTC for gonadotoxic therapy based on current standard of care.\n\nEXCLUSION CRITERIA:\n\n-An individual who meets any of the following criteria will be excluded from participation in this study:\n\n--Adults subjects with psychological, psychiatric, or other conditions which prevent giving fully informed consent.","FEMALE","4 Years","35 Years",{"count":55,"type":56},100,"ESTIMATED","OBSERVATIONAL","Background:\n\nMedical advances have improved survival rates for many cancers and other illnesses. This means that more people are coping with the long-term effects of these treatments. Some treatments can cause female infertility. Ovarian tissue cryopreservation (OTC) may help. Before undergoing a treatment that may damage their fertility, patients may opt to freeze a sample of ovarian tissue. The tissue contains immature egg cells. When thawed, the tissue can be reimplanted. This procedure can help women become pregnant.\n\nObjective:\n\nThis natural history study will create a databank of ovarian tissue. The NIH will provide OTC as a clinical service. The NIH will also request a portion of the tissue to use for research.\n\nEligibility:\n\nFemales aged 4 to 35 who opt to have OTC before receiving cancer treatment.\n\nDesign:\n\nParticipants will be screened. Their existing medical records will be reviewed.\n\nThey will be asked if they want to donate a portion of their ovarian tissue for research. No more than 20% of the tissue collected will be taken for research. Some other tissues that would otherwise be discarded will also be kept.\n\nMedical data from each participant may also be collected and stored in the database. This data may include results of routine blood tests, imaging tests, and other information. The data will be coded for privacy.\n\nParticipants will answer a questionnaire. They will be asked about their fertility treatment and general health. The survey takes about 30 minutes.\n\nThey will repeat the questionnaire once a year for 30 years.",[60,61,62],"Acute Ovarian Failure","Infertility","Early Menopause And Infertility In Females After Treatment For Childhood Cancer",[64,65,66,67,68],"Ovarian Tissue Preservation","Cancer Survivors And Infertility","Acute Ovarian Failure In The Childhood Cancer Survivor Study","Ovarian Failure After Radiation","Natural History","2026-06-23",{"date":71,"type":72},"2026-06-24","ACTUAL",{"date":74,"type":72},"2022-07-22",{"date":76,"type":56},"2041-09-21",{"name":15,"class":6},1]