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Universitätsspital Zürich","Zurich",{"type":57,"coordinates":133},[134,135],8.55,47.36667,{"lat":135,"lon":134},[138],{"name":139,"role":46,"phone":140,"phoneExt":10,"email":141},"Jan-Dirk Studt","+41442553488","jan-dirk.studt@usz.ch",{"type":43,"investigatorFullName":143,"investigatorTitle":144,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Casini Alessandro","Principal investigator","100494096","bleeding-of-unknown-cause-a-swiss-case-control-study-100494096",false,"NCT05713734","Bleeding of Unknown Cause: a Swiss Case-control Study","Bleeding of Unknown Cause, Insight Into a Multifactorial Bleeding Disorder: a Swiss Case-control Study","SWISS-BUC","Inclusion Criteria:\n\n* Man with ISTH BAT\\>3. If the calculated score includes a surgical bleeding, then two other items of the score should be \\>0\n* Woman with ISTH BAT \\>5 points. If the calculated score includes a surgical or a postpartum bleeding, then two other items of the score should be \\>0\n\nExclusion Criteria:\n\n* Ongoing pregnancy\n* Intake of antithrombotic treatment or non-steroidal anti-inflammatory drugs for least 10 days at time of blood collection\n* Intake of antifibrinolytic or blood product administration (factor concentrate, frozen fresh plasma, prothrombin complex concentrate) for least 14 days before blood collection\n* Active cancer (defined as cancer diagnosis within the last five years or treatment within the two last years before study inclusion)\n* Active autoimmune disease\n* Active chronic inflammatory disease\n* Severe liver disease (cirrhosis \\> Child A)\n* Renal insufficiency stage 3\n* Active or recent infection (within the last 30 days)\n* Recent hospitalization (\\\u003C3 months)\n* Recent surgery (\\\u003C3 months)\n* Recent trauma requiring medical intervention (\\\u003C3 months)",true,"ALL","16 Years","65 Years",{"count":158,"type":159},400,"ESTIMATED","OBSERVATIONAL","The goal of this prospective cohort is to identified specific biological patterns in patients with a bleeding of unknown cause and to study the specific mechanisms of the bleeding disorder for each subset of patients.",[163],"Bleeding Disorder",[165,166,167,28,168],"Bleeding","Hemostatics","Fibrin","Thrombin","2026-04-28",{"date":171,"type":172},"2026-04-29","ACTUAL",{"date":174,"type":172},"2023-04-01",{"date":176,"type":159},"2027-04-01",{"name":5,"class":6},7]