[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626015":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":38,"centralContacts":43,"locations":48,"responsibleParty":54,"collaborators":48,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":48,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":48,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":76,"overallStatus":83,"whyStopped":48,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":48},{"fullName":5,"class":6},"Asociación para Evitar la Ceguera en México","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental Group (BlinkEasy)","EXPERIMENTAL","Users assigned to this arm will use the 'BlinkEasy' software for 12 weeks.",[13],"Behavioral: Digital Blink Reminder Software (BlinkEasy)",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group (Standard Care)","ACTIVE_COMPARATOR","Users in this arm will follow the 20-20-20 visual hygiene rule for 12 weeks.",[19],"Behavioral: Visual Hygiene Education (20-20-20 Rule).",[21,30],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Digital Blink Reminder Software (BlinkEasy)","Participants will install the 'BlinkEasy' software on their primary digital display terminal (VDT). The application provides automated visual notifications at a frequency of approximately 8 reminders per minute, specifically designed to prompt full, voluntary blinks. Participants are instructed to perform two consecutive complete blinks upon each visual cue. The software operates during the user's active screen time throughout the 12-week study period. System logs will be recorded to monitor daily adherence and software usage time to ensure consistency in the intervention delivery.",[9],[27,28,29],"Active Blink Reminder Program","Automated Blink Training Software","Computer-based Blink Alert System",{"type":22,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"Visual Hygiene Education (20-20-20 Rule).","Participants will receive a standardized educational session and written materials on visual hygiene and ergonomic practices for screen use. The primary intervention is the '20-20-20 rule,' which instructs the user to take a 20-second break every 20 minutes of screen use by looking at an object at least 20 feet (6 meters) away to facilitate ocular muscle relaxation and natural blinking. This group will not use any automated reminder software. Adherence will be self-reported by participants during follow-up visits over the 12-week study period.",[15],[35,36,37],"20-20-20 Rule","Visual Hygiene Education","Standard Ergonomic Advice",[39],{"name":40,"affiliation":41,"role":42},"Ana Mercedes Garcia Albisua, MD","Asociación para Evitar la Ceguera en México (APEC).","PRINCIPAL_INVESTIGATOR",[44,50],{"name":45,"role":46,"phone":47,"phoneExt":48,"email":49},"José Francisco Heredia González, MD","CONTACT","52 + 5513095969",null,"heredia.04102001@gmail.com",{"name":51,"role":46,"phone":52,"phoneExt":48,"email":53},"Jorge Augusto Landetta Platonoff, MD","52 + 5583725429","joraulandgm@gmail.com",{"type":55,"investigatorFullName":48,"investigatorTitle":48,"investigatorAffiliation":48,"oldNameTitle":48,"oldOrganization":48},"SPONSOR","100626015","blink-reminders-and-meibomian-gland-loss-in-digital-screen-users-100626015",false,"NCT07430137","Blink Reminders and Meibomian Gland Loss in Digital Screen Users","Effect of a Blink Reminder Program on the Progression of Meibomian Gland Loss in Intensive Digital Screen Users: a Randomized Controlled Trial With Infrared Meibography","Inclusion Criteria:\n\n* Participants aged 18 to 40 years.\n* Intensive digital screen users, defined as an average screen time of ≥4 hours per day for at least 3 days per week.\n* Ocular Surface Disease Index (OSDI) score ≥13 (indicating mild to severe symptoms).\n* Non-invasive tear break-up time (NIBUT) ≤10 seconds measured by infrared meibography.\n* Presence of visible Meibomian glands on baseline meibography, allowing for quantitative analysis.\n* Technical ability to install and operate the BlinkEasy software on their primary digital device.\n\nExclusion Criteria:\n\n* Active ocular disease, including infections, corneal ulcers, or acute conjunctivitis.\n* History of ocular surgery (e.g., refractive surgery, cataract extraction) or significant ocular injury.\n* Use of topical ophthalmic medications affecting the ocular surface (e.g., steroids, glaucoma medications, or cyclosporine) within the last 3 months.\n* Active use of contact lenses that cannot be suspended for the duration of the 12-week study period.\n* Systemic conditions known to affect the ocular surface (e.g., Sjögren's syndrome, Rheumatoid Arthritis).\n* Diagnosis of Diabetes Mellitus (Type 1 or Type 2).","ALL","18 Years","40 Years",{"count":67,"type":68},28,"ESTIMATED","INTERVENTIONAL",[71],"NA","This randomized clinical trial aims to evaluate if a blink reminder program ('BlinkEasy') reduces the progression of Meibomian gland loss in intensive digital screen users over three months , using infrared meibography as the primary structural measure. Additionally, the study will analyze changes in dry eye symptoms using the 12-item Ocular Surface Disease Index (OSDI) questionnaire and non-invasive tear break-up time (NIBUT).",[74,75],"Dry Eye Syndromes","Meibomian Gland Dysfunction (Disorder)",[77,78,79,80,81,82],"Dry eye","Blinking","Meibography","Digital Displays","Meibomian Gland Atrophy","BlinkEasy","NOT_YET_RECRUITING","2026-02-25",{"date":86,"type":87},"2026-02-27","ACTUAL",{"date":89,"type":68},"2026-02-19",{"date":91,"type":68},"2026-08",{"name":5,"class":6}]