[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553060":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":53,"collaborators":18,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":58,"sex":64,"minAge":65,"maxAge":18,"enrollmentInfo":66,"targetDuration":18,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":37,"whyStopped":18,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Stanford University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise","EXPERIMENTAL","Participants will complete a 12-week, RLS specific exercise program including strength training, cardiovascular exercise, and stretching.",[13],"Behavioral: 12-Week RLS Exercise Program",{"label":15,"type":16,"description":17,"interventionNames":18},"Non-Exercise","NO_INTERVENTION","Participants will have no intervention or interaction for 12 weeks.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","12-Week RLS Exercise Program","Participants will complete 12 weeks of an evidence-based exercise program that has been used for people with RLS, designed for people with RLS, and was informed by exercise guidelines outlined by the American College of Sports Medicine (ACSM) and the American Heart Association, and Center for Disease Control.\n\nThe program includes three sessions per week for 12 weeks including:\n\n* cardiovascular exercise (e.g., walking\u002Fjogging, bicycling) for 30 minutes\u002Fday on at least 3 days\u002Fweek at a moderate-to-vigorous intensity\n* strength training on 2 non-consecutive days\u002Fweek targeting major muscle groups for approximately 30 minutes\n* Stretching all major muscle groups on three or more days per week",[9],[26],{"name":27,"affiliation":5,"role":28},"Emmanuel Mignot, MD, PhD","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},"Katie Cederberg, PhD","CONTACT","(650) 725-6517","kcederb@stanford.edu",[36],{"facility":5,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","Stanford","California","94304","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-122.16608,37.42411,{"lat":47,"lon":46},[50],{"name":31,"role":32,"phone":51,"phoneExt":18,"email":52},"650-725-6517","RLSresearch@stanford.edu",{"type":28,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Emmanuel Mignot","Craig Reynolds Professor of Sleep Medicine","100553060","blood-changes-after-exercise-in-restless-legs-syndrome-100553060",false,"NCT06481176","Blood Changes After Exercise in Restless Legs Syndrome","Proteomic Response to Exercise in Adults With Restless Legs Syndrome","PEARLS","Inclusion Criteria:\n\n* age 18 years or older;\n* diagnosis of RLS;\n* presence of moderate-to-severe RLS (IRLS score\\>15);\n* currently untreated RLS;\n* being non-active defined as not engaging in regular activity (30 minutes accumulated per day) on more than 2 days of the week during the previous six months;\n* ability to walk without assistance (does not use a cane\u002Fwalker\u002Fwheelchair for mobility;\n* willing to complete outcome measures and complete the exercise program\n\nExclusion Criteria:\n\n* present with a condition that can mimic RLS or cause secondary RLS (e.g., iron deficiency anemia, radiculopathy, peripheral edema, peripheral neuropathy, diabetes);\n* are at moderate or high risk for undertaking strenuous or maximal exercise","ALL","18 Years",{"count":67,"type":68},30,"ESTIMATED","INTERVENTIONAL",[71],"NA","The goal of this clinical trial is to learn how exercise changes molecules in the blood in people with restless legs syndrome (RLS) to better understand the cause(s) of RLS. The main questions the investigators aim to answer are:\n\nHow does long-term exercise change proteins in the blood?\n\nHow does a single exercise session change proteins in the blood?\n\nThe investigators will compare long-term exercise to no exercise to see if the changes in proteins are specific to exercise.\n\nParticipants will complete an exercise test and provide blood samples before and after the exercise test. Participants will be randomized (like the flip of a coin) in to either the exercise or no-exercise group for 12 weeks and then complete the exercise test and blood samples again at the end.",[74],"Restless Legs Syndrome",[9,76],"Proteomics","2024-11-25",{"date":79,"type":80},"2024-11-27","ACTUAL",{"date":82,"type":80},"2024-10-21",{"date":84,"type":68},"2026-12",{"name":5,"class":6},1]