[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100587486":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":36,"centralContacts":37,"locations":47,"responsibleParty":65,"collaborators":36,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":36,"enrollmentInfo":77,"targetDuration":36,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":50,"whyStopped":36,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Hospices Civils de Lyon","OTHER",[8,14,18,22,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Peritoneal metastases colorectal cancer","EXPERIMENTAL","* Peritoneal metastases colorectal cancer histologically proven\n* Synchronous or metachronous peritoneal metastases.\n* Patients eligible for initial cytoreduction surgery.\n* Non mucinous tumor (mucinous cells contingent \\\u003C30%).",[13],"Biological: Blood sampling",{"label":15,"type":10,"description":16,"interventionNames":17},"Colorectal cancer","Histologically proven colorectal cancer with no known metastatic",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Non-oncological chronic inflammatory diseases","Surgery for inflammatory bowel disease (Crohn's, chronic ulcerative colitis) such as ileocaecal resection, colectomy, and bowel resection.",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Non-malignant diseases","Non-inflammatory and non-oncological diseases:\n\n* Parietal repairs.\n* Elective sigmoidectomy for diverticulosis",[13],{"label":27,"type":10,"description":28,"interventionNames":29},"Abdominal sepsis conditions","* Peritonitis due to digestive perforation in non-oncological pathology.\n* Non-perforated appendicitis.\n* Cholecystitis.",[13],[31],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"BIOLOGICAL","Blood sampling","Inclusion (baseline): 28 mL Incision (surgery): 18 mL End surgery: 18 mL H+12 after end surgery: 18 mL H+4 after end surgery: 18 mL H+48 after end surgery: 18 mL H+72 after end surgery: 18 mL D+7 after end surgery: 18 mL D+14 after surgery: 18 mL 4 to 6 weeks after surgery:28 mL",[27,15,23,19,9],null,[38,43],{"name":39,"role":40,"phone":41,"phoneExt":36,"email":42},"Vahan KEPENEKIAN, MD, PhD","CONTACT","+33 478 862 371","vahan.kepenekian@chu-lyon.fr",{"name":44,"role":40,"phone":45,"phoneExt":36,"email":46},"Laurent VILLENEUVE, PhD","+33478 864 536","laurent.villeneuve@chu-lyon.fr",[48],{"facility":49,"status":50,"city":51,"state":36,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Hôpital Lyon Sud","RECRUITING","Pierre-Bénite","69310","France","FR",{"type":56,"coordinates":57},"Point",[58,59],4.82424,45.70359,{"lat":59,"lon":58},[62,64],{"name":39,"role":40,"phone":63,"phoneExt":36,"email":42},"+33478862371",{"name":44,"role":40,"phone":45,"phoneExt":36,"email":46},{"type":66,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR","100587486","blood-clearance-kinetics-of-the-nucleosome-and-ctcf-in-peritoneal-metastasis-colorectal-cancer-100587486",false,"NCT06929013","Blood Clearance Kinetics of the Nucleosome and CTCF in Peritoneal Metastasis Colorectal Cancer.","Monitoring of Blood Clearance Kinetics of the Nucleosome and CTCF in Peri-operative Management of Peritoneal Metastasis Colorectal Cancer.","NUCLEAR","Inclusion Criteria:\n\n* Common criteria:\n\n  * Male\u002Ffemale over 18 years of age.\n  * Weight ≥ 55 kg at inclusion.\n  * Signature of a free and informed consent form.\n* Specific criteria:\n\nGroup 1:\n\n* Peritoneal metastases colorectal cancer histologically proven\n* Synchronous or metachronous peritoneal metastases.\n* Patients eligible for initial cytoreduction surgery.\n* Non mucinous tumor (mucinous cells contingent \\\u003C30%).\n\nGroup 2:\n\nColorectal cancer\n\nGroup 3:\n\nNon-oncological chronic inflammatory diseases\n\nGroup 4:\n\nNon-oncological chronic inflammatory diseases : parietal repairs, elective sigmoidectomy for diverticulosis\n\nGroup 5:\n\nAbdominal sepsis conditions: peritonitis due to digestive perforation in non-oncological pathology, non-perforated appendicitis, cholecystitis.\n\nNon inclusion Criteria:\n\n* Patient with an active cancer (excluding colorectal cancer).\n* Person with a progressive autoimmune disease.","ALL","18 Years",{"count":78,"type":79},58,"ESTIMATED","INTERVENTIONAL",[82],"NA","Colorectal cancer is highly prevalent in France, ranking second among women and third among men. Its primary metastatic sites include the liver, lungs, and peritoneum. For peritoneal metastases, when the disease is moderately extensive, cytoreductive surgery is recommended in an expert centre. Following this procedure, the surgeon uses the CC-Score (Completeness of Cytoreduction after Surgery Score) to assess the completeness of surgical resection by evaluating the largest remaining tumor residue. This subjective score is currently the main prognostic factor for oncological outcomes post-surgery. However, there is no objective score based on biological criteria to evaluate the radicality of resection, despite the hypothesis that the micrometastatic component of the disease could be biologically assessed using appropriate circulating markers.\n\nNew biomarkers are emerging and appear relevant for determining the presence of tumor residual disease. Notable among these are circulating tumor DNA, which can detect mutated DNA released by tumor cells into the patient's blood through high-throughput sequencing, and new markers related to epigenetic modifications in cancer cells. These markers target specific nucleosomes or the transcription factor CTCF and show promise in detecting residual disease.\n\nTo effectively use these markers for constructing a biological score to detect residual disease in peritoneal carcinomatosis, it is essential to understand their perioperative kinetics. This is crucial because cellular debris release is expected post-surgery, necessitating the determination of the most relevant time point for measurement. Additionally, these markers appear to be correlated with blood inflammation levels, requiring a description of this correlation to account for this potential confounding factor. Finally, the sensitivity and specificity of these markers must be determined by studying their perioperative kinetics in patient groups undergoing surgeries other than cytoreductions for peritoneal carcinomatosis.",[85,86],"Peritoneal Carcinomatosis","Peritoneal Metastases From Colorectal Cancer",[88,89,90,91],"Biomarkers","Peritoneal carcinomatosis","CTCF","Nucleosome","2026-02-12",{"date":94,"type":95},"2026-02-13","ACTUAL",{"date":97,"type":95},"2025-05-06",{"date":99,"type":79},"2026-06-20",{"name":5,"class":6},1]