[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100549457":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":38,"centralContacts":51,"locations":60,"responsibleParty":77,"collaborators":79,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":88,"sex":94,"minAge":95,"maxAge":55,"enrollmentInfo":96,"targetDuration":55,"studyType":99,"phases":100,"briefSummary":102,"conditions":103,"keywords":55,"overallStatus":62,"whyStopped":55,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},{"fullName":5,"class":6},"University of Aarhus","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Early initiated Blood Flow Restriction Exercise","EXPERIMENTAL","Receives an intervention in adjunct to usual care in weeks 1-12, and continues with usual care in weeks 13-24.",[13],"Other: Early exercise with partial Blood Flow Restriction",{"label":15,"type":10,"description":16,"interventionNames":17},"Late initiated Blood Flow Restriction Exercise","Receives usual care in weeks 1-12, and receives an intervention in adjunct to usual care weeks 13-24.",[18],"Other: Late exercise with partial Blood Flow Restriction",[20,32],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Early exercise with partial Blood Flow Restriction","The intervention comprises of 12 weeks of blood flow restriction exercise in weeks 1-12 after injury. Three weekly exercise sessions are performed. Six supervised sessions are provided during the 12 weeks.\n\nBlood flow restriction of 80% of the limb occlusion pressure required to fully restrict the arterial blood flow is employed.\n\nThe intervention comprises three exercises: Seated leg extension, standing knee flexion, and seated heel-rise performed at home as an adjunct to usual care treatment.\n\nEach exercise is performed in four sets of 30, 15, 15, +1 repetitions, with the fourth set (+1) being as many repetitions as possible.\n\nPause in between sets is 30 seconds. Pause in between exercises are 120 seconds.\n\nIn weeks 13-24, patients in this arm follow usual care treatment.",[9],[25,26,27,28,29,30,31],"BFR","BFRE","Blood Flow Restriction Exercise","BFR-T","Blood Floow Restriciton Training","LL-BFR","Low Load Blood Flow Restriction",{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"Late exercise with partial Blood Flow Restriction","The intervention comprises of 12 weeks of blood flow restriction exercise in weeks 13-24 after injury. Three weekly exercise sessions are performed. Six supervised sessions are provided during the 12 weeks.\n\nBlood flow restriction of 80% of the limb occlusion pressure required to fully restrict the arterial blood flow is employed.\n\nThe intervention comprises three exercises: Leg press in machine, heel-rise in machine, knee flexion in machine performed at training facilities as an adjunct to usual care treatment. If facilities are unavailable, three home-based exercises will be provided.\n\nEach exercise, regardless of study arm, is performed in four sets of 30, 15, 15, +1 repetitions, with the fourth set (+1) being as many repetitions as possible.\n\nIn weeks 1-12, patients in this arm follow usual care treatment.",[15],[25,26,27,28,37,30,31],"Blood Flow Restriction Training",[39,42,45,48],{"name":40,"affiliation":5,"role":41},"Andreas Bentzen, MHSc","PRINCIPAL_INVESTIGATOR",{"name":43,"affiliation":5,"role":44},"Inger Mechlenburg, DMSc","STUDY_DIRECTOR",{"name":46,"affiliation":47,"role":44},"Per H. Gundtoft, MD, PhD","Aarhus University Hospital",{"name":49,"affiliation":50,"role":44},"Stian L. Jørgensen, PT, PhD","Regionshospitalet Horsens",[52,57],{"name":40,"role":53,"phone":54,"phoneExt":55,"email":56},"CONTACT","4553109112",null,"andreas.bentzen@clin.au.dk",{"name":43,"role":53,"phone":58,"phoneExt":55,"email":59},"4521679062","inger.mechlenburg@clin.au.dk",[61],{"facility":47,"status":62,"city":63,"state":55,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"RECRUITING","Aarhus N","8200","Denmark","DK",{"type":68,"coordinates":69},"Point",[70,71],10.17317,56.20367,{"lat":71,"lon":70},[74],{"name":75,"role":53,"phone":76,"phoneExt":55,"email":55},"Inger Mechlenburg","+45 21679062",{"type":78,"investigatorFullName":55,"investigatorTitle":55,"investigatorAffiliation":55,"oldNameTitle":55,"oldOrganization":55},"SPONSOR",[80,81,83,85],{"name":47,"class":6},{"name":82,"class":6},"Aalborg University Hospital",{"name":84,"class":6},"Gødstrup Hospital",{"name":50,"class":6},"100549457","blood-flow-restriction-exercise-in-patients-with-an-achilles-tendon-rupture-100549457",false,"NCT06434272","Blood Flow Restriction Exercise in Patients With an Achilles Tendon Rupture","The Effectiveness of Low-load Blood Flow Restriction Exercise in Patients With an Acute Achilles Tendon Rupture Treated Non-surgically","BEAN","Inclusion Criteria:\n\n* aged 18 years or older\n* have started initial treatment within 72 hours of Achilles tendon rupture\n* understand written and spoken Danish\n\nExclusion Criteria:\n\n* bilateral Achilles tendon rupture\n* previous Achilles tendon rupture in either leg\n* decreased lower extremity function, caused by conditions other than Achilles tendon rupture\n* treated with fluoroquinolones within the last six months\n* treated with corticosteroid injection(s) in the area near the Achilles tendon within the last six months.\n* diabetes\n* previous diagnosed thrombosis\n* Known atherosclerosis in the peripheral arteries of the lower limb\n* other reasons for exclusion (cognitive deficits, inability to provide informed consent, requiring cast-treatment due to low compliance regarding gradual wedge removal, etc.)","ALL","18 Years",{"count":97,"type":98},218,"ESTIMATED","INTERVENTIONAL",[101],"NA","The goal of this clinical trial is to gain insights into the effects of Blood Flow Restriction Exercise (BFRE) in patients with an acute Achilles tendon Rupture. The main questions it aims to answer are:\n\nIs BFRE an effective adjunct to usual care when compared with only usual care? When is the optimal timing for initiating BFRE: In the early treatment stage or at the later stage after hospital treatment? Participants will receive an intervention comprising 12 weeks of BFRE as an adjunct to usual care.\n\n* Either in the initial 1-12 weeks after Achilles tendon rupture, or\n* In the following 13-24 weeks after Achilles tendon rupture\n\nResearchers will compare the two groups at 13 weeks (3 months) to compare BFRE to usual care, and at 25 weeks (6 months) to compare the two time points for initiating BFRE (early vs. late).",[104],"Achilles Tendon Rupture","2025-04-14",{"date":107,"type":108},"2025-04-17","ACTUAL",{"date":110,"type":108},"2025-01-28",{"date":112,"type":98},"2028-01-09",{"name":5,"class":6},1]