[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100514058":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":36,"responsibleParty":63,"collaborators":23,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":23,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":23,"overallStatus":39,"whyStopped":23,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Oxford","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"High carbohydrate, low fat diet","EXPERIMENTAL","65% of energy is derived from carbohydrates, 20% from fat, and 15% from protein.",[13],"Other: Diet",{"label":15,"type":10,"description":16,"interventionNames":17},"High fat, low carbohydrate diet","65% of energy is derived from fat, 20% from carbohydrates, and 15% from protein.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"Diet","Eucaloric diet enriched in either carbohydrates or fat (both contributing to 65% total energy intake)",[9,15],null,[25],{"name":26,"affiliation":5,"role":27},"Leane Hodson","PRINCIPAL_INVESTIGATOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":23,"email":33},"David J Dearlove","CONTACT","07739460623","david.dearlove@ocdem.ox.ac.uk",{"name":26,"role":31,"phone":23,"phoneExt":23,"email":35},"leanne.hodson@ocdem.ox.ac.uk",[37,54],{"facility":38,"status":39,"city":40,"state":23,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford","RECRUITING","Oxford","OX3 7LE","United Kingdom","UK",{"type":45,"coordinates":46},"Point",[47,48],-1.25596,51.75222,{"lat":48,"lon":47},[51],{"name":52,"role":31,"phone":53,"phoneExt":23,"email":35},"Leanne Hodson, PhD","01865 857224",{"facility":55,"status":39,"city":40,"state":23,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":56,"geoPoint":58,"contacts":59},"Oxford Centre for Diabetes, Endocrinology and Metabolism",{"type":45,"coordinates":57},[47,48],{"lat":48,"lon":47},[60,62],{"name":61,"role":31,"phone":53,"phoneExt":23,"email":35},"Leanne Hodson",{"name":52,"role":27,"phone":23,"phoneExt":23,"email":23},{"type":64,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100514058","blood-lipid-responses-to-diet-macronutrients-100514058",false,"NCT05973539","Blood Lipid Responses to Diet Macronutrients","Investigating Blood Lipid Responses to Dietary Macronutrient Content","BoLD","Inclusion Criteria:\n\n* Participant is willing and able to give informed consent for participation in the study.\n* Male or Female, aged ≥18 to ≤65 years\n* Body mass index (BMI) ≥19 to ≤35 kg\u002Fm2\n* No medical condition or relevant drug therapy that is known to affect the liver, adipose tissue, or cardiac metabolism.\n* Weight stable for the previous 3 months\n\nExclusion Criteria:\n\n* Aged \\\u003C18 or \\>65 years\n* BMI \\\u003C19 or \\>35 kg\u002Fm2\n* A blood haemoglobin \\\u003C135 mg\u002FdL for men and \\\u003C120 mg\u002FdL for women\n* Donated (or lost) ≥250 mL of blood in the previous two months\n* On a weight loss diet or decreased their body weight by \\>5% in the previous 3 months\n* Currently adhering to or have consumed in the previous 3 months a diet with a notably altered macro-nutrient content (e.g. high-fat - low-carbohydrate diet)\n* Have increased their body weight by \\>5% in the previous 3 months\n* Any metabolic condition or relevant drug therapy\n* Current smoker\n* History of alcoholism or a greater than recommended alcohol intake (\\>30 g of alcohol daily for men and \\>20 g of alcohol daily for women)\n* History of albumin allergy.\n* Pregnant or nursing mothers\n* History of severe claustrophobia",true,"ALL","18 Years","65 Years",{"count":78,"type":79},60,"ESTIMATED","INTERVENTIONAL",[82],"NA","The macronutrient composition of a diet (proportions of carbohydrates, fats and proteins) strongly influences the way the body stores and utilises substrates (e.g., fats and sugars), which in turn influences the risk of developing cardiometabolic diseases (e.g., coronary artery disease or insulin resistance). The optimal dietary composition to lower the risk of cardiometabolic disease is unknown.\n\nIn a randomized, parallel design, this study will investigate how the overconsumption of carbohydrates and fats affects blood lipid responses and liver metabolism in adults free from metabolic disease. By genotyping participants, the interaction between macronutrient content and an individual's genes on blood lipid responses and liver metabolism will be examined.",[85],"Nutritional and Metabolic Diseases","2026-05-06",{"date":88,"type":89},"2026-05-11","ACTUAL",{"date":91,"type":89},"2023-02-15",{"date":93,"type":79},"2028-01",{"name":5,"class":6},2]