[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613494":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":54,"collaborators":57,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":25,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":91,"whyStopped":25,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Loughborough University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Without any medication affecting bone","EXPERIMENTAL","Participants in this arm are postmenopausal women with low bone density who are not taking any bone medication for at least 12 months. They will participate in a 12-month supervised high impact unilateral hopping exercise.",[13],"Behavioral: EXERCISE TRAINING",{"label":15,"type":10,"description":16,"interventionNames":17},"With osteoporosis medication (antiresorptive )","Participants in this arm are postmenopausal women with low bone density who are taking antiresorptive medication for at least 12 months. They will participate in a 12-month supervised high impact unilateral hopping exercise.",[13,18],"Drug: Antiresorptive medication (routine clinical care)",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","EXERCISE TRAINING","The unilateral high-impact (hopping) exercise will be on one randomly allocated exercise leg, with the contralateral leg being untrained to provide a control leg. Each session will begin with a warm-up targeting the legs and lower back. The progressive exercise regimen consists of multidirectional hopping exercises that will gradually increase in technique, intensity, and frequency to ensure safety. It will be personalised according to the participants' physical abilities and responses during or after the exercise.",[15,9],null,{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":25},"DRUG","Antiresorptive medication (routine clinical care)","Participants in this arm are already taking prescribed antiresorptive medication as part of standard clinical care. The study will not provide or modify the medication.",[15],[32],{"name":33,"affiliation":5,"role":34},"Katherine Brooke-Wavell, Professor","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Nora Alohaly, PhD","CONTACT","+441509226207","n.alohaly@lboro.ac.uk",[42],{"facility":5,"status":25,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":25},"Loughborough","Leicestershire","LE11 3TU","United Kingdom","UK",{"type":49,"coordinates":50},"Point",[51,52],-1.2,52.76667,{"lat":52,"lon":51},{"type":34,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Katherine Brooke-Wavell","Professor",[58,60],{"name":59,"class":6},"University of Sheffield",{"name":61,"class":6},"University of Cambridge","100613494","bone-health-in-postmenopausal-women-the-effect-of-exercise-with-or-without-medication-for-osteoporosis-100613494",false,"NCT07267325","Bone Health in Postmenopausal Women: The Effect of Exercise With or Without Medication for Osteoporosis","The Effect of Exercise With or Without Antiresorptive Therapy, on Bone Properties in Postmenopausal Women With Low BMD - Randomised Controlled Unilateral Intervention Trial","BEAT-OP","Inclusion Criteria:\n\n* Women aged 55-75 years old\n* \\>4y since menopause\u002Fhysterectomy\u002Foophorectomy.\n* Baseline femoral neck or lumber spine BMD T-score between -1 and -3.\n* Able to complete the hopping exercises.\n* Have no regular involvement for more than once\u002Fweek in:\n\n  1. Strength, powerlifting or high load resistance exercise.\n  2. High to moderate impact exercise that known to involve ground reaction forces 2 to 4 times greater than body weight (e.g. Jogging).\n* Treatment group: taking antiresorptive treatment for osteoporosis continuously for at least 12 months, and who intend to continue this medication for the rest of the study.\n* Control group: not taking any medication affecting bone and no intention to commence such medication for the rest of the study.\n\nExclusion Criteria:\n\n* Body mass index (BMI) \\>35 kg\u002Fm2\n* Any medical condition, surgery, or injuries that contraindicate exercises including lower limb or back pain, knee or hip osteoarthritis.\n* Vertebral fracture or multiple low trauma fractures (recent expert consensus recommends lower impact exercise for these groups)\n* Replacement of hip joint(s)",true,"FEMALE","55 Years","75 Years",{"count":75,"type":76},110,"ESTIMATED","INTERVENTIONAL",[79],"NA","Osteoporosis is a systemic bone disorder characterised by a reduced bone mass and structural deterioration, increasing the risk of fragility fractures, particularly in women post-menopause. Bone mass and structure can be assessed by scans.\n\nAntiresorptive medications are commonly prescribed to reduce bone resorption, preventing further bone loss and thus reducing the possibility of fracture. Exercise can also benefit bone mass and structure but current evidence do not show whether exercise is more, or less, effective in combination with antiresorptive medication.\n\nThis study will compare the effect of a brief, home-based exercise programme on bone mineral and structural properties in women taking\u002F not taking antiresorptive medication.",[82],"Osteoporosis in Post-menopausal Women",[84,85,86,87,88,89,90],"Exercise","Bone mineral density","Bone strength","Bone geometry","Fracture risk","Bone structure","Biomarkers","NOT_YET_RECRUITING","2025-12-04",{"date":94,"type":95},"2025-12-05","ACTUAL",{"date":97,"type":76},"2026-01-01",{"date":99,"type":76},"2027-09",{"name":5,"class":6},1]