[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639840":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":28,"locations":35,"responsibleParty":51,"collaborators":11,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":11,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":11,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":11,"overallStatus":73,"whyStopped":11,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Alexandria University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"directly printed aligners","EXPERIMENTAL",null,[13],"Other: Directly printed aligners using Tera Harz TA28 resin",{"label":15,"type":16,"description":11,"interventionNames":17},"thermoformed aligners","ACTIVE_COMPARATOR",[18],"Other: PETG thermoplastic sheets",[20,24],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"Directly printed aligners using Tera Harz TA28 resin","Aligners will be digitally designed using the latest version of ArchForm software for segmentation of dental arches, virtual tooth movement planning and generation of sequential treatment stages, the finalized setups will be exported as STL files.",[9],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":11},"PETG thermoplastic sheets","Aligners were digitally designed using the latest version of ArchForm software .The 3D-printed resin models which were used as a mold for aligner thermoforming, were fabricated by Anycubic Photon Mono M5s (12K resolution) (Anycubic, China) 3D printing machine.",[15],[29],{"name":30,"role":31,"phone":32,"phoneExt":33,"email":34},"Ahmed Karkoura, BDS","CONTACT","01110309060","002","ahmed.abdalrahman.dent@alexu.edu.eg",[36],{"facility":37,"status":11,"city":38,"state":11,"zip":11,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Faculty of Dentistry, Alexandria University","Alexandria","Egypt","EG",{"type":42,"coordinates":43},"Point",[44,45],29.91582,31.20176,{"lat":45,"lon":44},[48,49],{"name":30,"role":31,"phone":11,"phoneExt":11,"email":11},{"name":30,"role":50,"phone":11,"phoneExt":11,"email":11},"PRINCIPAL_INVESTIGATOR",{"type":52,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100639840","bone-metabolism-in-patients-treated-with-3d-printed-aligners-versus-thermoformed-aligners-100639840",false,"NCT07617571","Bone Metabolism in Patients Treated With 3d Printed Aligners Versus Thermoformed Aligners","Bone Metabolism in Patients Treated With 3d Printed Aligners Versus Thermoformed Aligners (Randomized Controlled Clinical Trial)","Inclusion Criteria:\n\n* Minor malocclusion (2 to 4 mm of crowding) .\n* Patients in need for Antero-posterior expansion and labial tipping of incisors without interproximal reduction\n* No use of anti-inflammatory drugs or antibiotics in the past 6 months.\n* Periodontal parameters of gingival index \\\u003C1 and no pocketing with a generalized pocketing depth of \\\u003C3mm.\n* Radiographic parameters of no crestal bone loss.\n* No history of smoking.\n\nExclusion Criteria:\n\n* Signs of inflammation of the gingiva, and periodontitis.\n* Systemic conditions (kidney disease, HIV, and liver disease).\n* Teeth missing or poor oral hygiene.\n* Bone disease e.g.; osteoporosis.","ALL","18 Years","25 Years",{"count":64,"type":65},30,"ESTIMATED","INTERVENTIONAL",[68],"NA","Background: Orthodontic forces induce tissue reactions by triggering perturbations from orthodontic appliances, which lead to the modelling and remodelling of alveolar bone. Despite the growing popularity of 3D-printed aligners, no studies have compared their effects on bone metabolism in comparison with thermoformed aligners. Aim: This study aims to assess bone metabolism in patients undergoing treatment with 3D-printed aligners versus thermoformed aligners.",[71,72],"Bone Metabolism","Orthodontic Aligners","NOT_YET_RECRUITING","2026-05-24",{"date":76,"type":77},"2026-06-01","ACTUAL",{"date":76,"type":65},{"date":80,"type":65},"2026-07-01",{"name":5,"class":6},1]