[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625598":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":32,"responsibleParty":47,"collaborators":26,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":53,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":26,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":73,"overallStatus":35,"whyStopped":26,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Sana'a University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"PRF Group","EXPERIMENTAL","Participants undergoing cystic enucleation in the jaws will receive autologous Platelet-Rich Fibrin (PRF) placed into the osseous defect immediately after surgical enucleation.",[13],"Biological: Autologous Platelet-Rich Fibrin (PRF)",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","ACTIVE_COMPARATOR","Participants undergoing cystic enucleation of jaw cysts will receive conventional surgical management without the application of platelet-rich fibrin (PRF). The osseous defect will be left to heal naturally following standard enucleation and wound closure procedures.",[19],"Procedure: Conventional Surgical Management",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BIOLOGICAL","Autologous Platelet-Rich Fibrin (PRF)","Autologous platelet-rich fibrin (PRF) prepared from the participant's own venous blood will be placed into the osseous defect immediately after cystic enucleation. PRF will be prepared using standard centrifugation protocols and applied to promote bone regeneration.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"PROCEDURE","Conventional Surgical Management","Conventional cystic enucleation will be performed without the use of platelet-rich fibrin (PRF). The osseous defect will be managed according to standard surgical protocol and allowed to heal naturally.",[15],[33],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":26,"geoPoint":26,"contacts":41},"Faculty of Medicine and Health Sciences - Sana'a University","RECRUITING","Sanaa","Sanaa Governorate","00000","Yemen","YE",[42],{"name":43,"role":44,"phone":45,"phoneExt":26,"email":46},"lamees F Alareeki, BDS","CONTACT","+967772377003","lamis.alarigi@su.edu.ye",{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Lamees Fozi Alareeki","Master's Degree Candidate, Faculty of Dentistry, Sana'a University","100625598","bone-regeneration-using-prf-after-cyst-enucleation-100625598",false,"NCT07424716","Bone Regeneration Using PRF After Cyst Enucleation","Clinical Efficacy of Platelet-Rich Fibrin in Osseous Regeneration After Cystic Enucleation","PRF-Bone","Inclusion Criteria:\n\n* Patients diagnosed with odontogenic cysts requiring surgical enucleation.\n* Presence of a postoperative osseous defect in the jaws after cyst enucleation.\n* Age ≥ 18 years.\n* Systemically healthy patients (ASA I or II).\n* Patients willing to participate and sign informed consent.\n\nExclusion Criteria:\n\n* Patients with systemic diseases affecting bone healing (e.g., uncontrolled diabetes, osteoporosis).\n* Patients receiving bisphosphonates or long-term corticosteroid therapy.\n* Smokers (\\>10 cigarettes\u002Fday).\n* Pregnant or lactating women.\n* Patients with acute infection at the surgical site.\n* Patients unwilling to participate or unable to attend follow-up visits.","ALL","18 Years","80 Years",{"count":63,"type":64},20,"ESTIMATED","INTERVENTIONAL",[67],"NA","This randomized controlled clinical trial aims to evaluate the clinical efficacy of autologous platelet-rich fibrin (PRF) in promoting osseous regeneration following cystic enucleation in the jaws. The study will assess bone healing outcomes and compare PRF application with conventional management methods.",[70,71,72],"Odontogenic Cyst","Jaw Cysts","Osseous Defect After Cyst Enucleation",[74,75,76,77,78,79,80,81],"Platelet-Rich Fibrin","PRF","Cyst Enucleation","Bone Regeneration","Randomized Controlled Trial","Oral Surgery","Osseous Healing","Jaw Bone Defect","2026-02-14",{"date":84,"type":85},"2026-02-20","ACTUAL",{"date":87,"type":85},"2025-05-19",{"date":89,"type":64},"2026-10-19",{"name":5,"class":6},1]