[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644469":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":40,"responsibleParty":70,"collaborators":73,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":26,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":26,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":98,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"University of Belgrade","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"GTO® + NIPSA","EXPERIMENTAL","Regenerative periodontal therapy using GTO® collagenated xenogeneic bone substitute in combination with the Non-Incised Papilla Surgical Approach (NIPSA).",[13],"Procedure: GTO® with NIPSA surgical approach",{"label":15,"type":16,"description":17,"interventionNames":18},"GenOs® + NIPSA","ACTIVE_COMPARATOR","Regenerative periodontal therapy using GenOs® collagenated xenogeneic bone substitute in combination with the Non-Incised Papilla Surgical Approach (NIPSA).",[19],"Procedure: GenOs® + NIPSA",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","GTO® with NIPSA surgical approach","Regenerative periodontal surgical treatment using the Non-Incised Papilla Surgical Approach (NIPSA) combined with GTO® collagenated xenogeneic bone substitute for the treatment of intrabony periodontal defects.",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"Regenerative periodontal surgical treatment using the Non-Incised Papilla Surgical Approach (NIPSA) combined with GenOs® collagenated xenogeneic bone substitute for the treatment of intrabony periodontal defects.",[15],[31],{"name":32,"affiliation":33,"role":34},"Iva Z Milinkovic, DDS, PhD","School of Dental Medicine, University of Belgrade, Implant Research Centre and Department of Periodontology and Oral Medicine","PRINCIPAL_INVESTIGATOR",[36],{"name":32,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","+381113629201","iva.milinkovic@gmail.com",[41,58],{"facility":42,"status":43,"city":44,"state":45,"zip":26,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Department of Periodontology, School of Dental Medicine, University of Cagliari Cittadella Universitaria di Monserrato Monserrato (CA), Italy","RECRUITING","Cagliari","Italy","IT",{"type":48,"coordinates":49},"Point",[50,51],9.11917,39.23054,{"lat":51,"lon":50},[54],{"name":55,"role":37,"phone":56,"phoneExt":26,"email":57},"Nicola A Valente, DDS, MS, PhD","+39 338 5932069","navalentedds@gmail.com",{"facility":59,"status":43,"city":60,"state":26,"zip":26,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Department of Periodontology and Research Implant Center, School of Dental Medicine, University of Belgrade","Belgrade","Serbia","RS",{"type":48,"coordinates":64},[65,66],20.46513,44.80401,{"lat":66,"lon":65},[69],{"name":32,"role":37,"phone":38,"phoneExt":26,"email":39},{"type":34,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Iva Milinkovic","Professor",[74],{"name":75,"class":6},"Cittadella Universitaria","100644469","bone-substitutes-and-nipsa-in-intrabony-periodontal-defects-a-randomized-controlled-trial-100644469",false,"NCT07671963","Bone Substitutes and NIPSA in Intrabony Periodontal Defects: A Randomized Controlled Trial","Regenerative Therapy of Intrabony Periodontal Defects Using Bone Substitutes and a Minimally Invasive Nonincised Papilla Surgical Approach - A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Diagnosis of Stage III periodontitis\n* At least one intrabony periodontal defect with probing depth \\> 5 mm following completion of non-surgical periodontal therapy\n* Full-mouth plaque score (FMPS) \\\u003C 20%\n* Full-mouth bleeding score (FMBS) \\\u003C 20%\n* Ability to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Systemic medical contraindications to periodontal surgery\n* History of head and neck radiotherapy\n* Poor oral hygiene or lack of motivation\u002Fcompliance\n* Uncontrolled diabetes mellitus\n* Pregnancy or lactation\n* Treatment with antiresorptive medications or other drugs affecting bone remodeling\n* Heavy smoking (\\>20 cigarettes\u002Fday)",true,"ALL","18 Years","80 Years",{"count":88,"type":89},30,"ESTIMATED","INTERVENTIONAL",[92],"NA","This multicenter randomized controlled clinical trial aims to compare the clinical, radiographic, microbiological and molecular outcomes of two collagenated xenogeneic bone substitutes (GTO® and GenOs®) used in combination with the Non-Incised Papilla Surgical Approach (NIPSA) for the treatment of intrabony periodontal defects. The study will evaluate whether differences exist between the two biomaterials with respect to clinical attachment gain, defect resolution, wound healing and biological markers of regeneration.",[95,96,97],"Periodontitis (Stage 3)","Minimally Invasive Surgical Procedures","Bone Substitutes",[99,100,101,102],"periodontitis","regenerative treatment","NIPSA","bone substitutes","2026-06-22",{"date":105,"type":106},"2026-06-26","ACTUAL",{"date":108,"type":89},"2026-07-01",{"date":110,"type":89},"2027-03-01",{"name":5,"class":6},2]