[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600379":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":39,"locations":47,"responsibleParty":65,"collaborators":26,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":26,"enrollmentInfo":77,"targetDuration":26,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":92,"whyStopped":26,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Boston Medical Center","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Five-point ultrasound guided diuresis","EXPERIMENTAL","Participants randomized to this study arm will have their diuresis guided by five-point ultrasound to assess venous congestion and receive standard of care.",[13,14],"Device: Five-point ultrasound","Other: Standard of care",{"label":16,"type":17,"description":18,"interventionNames":19},"Standard of care guided diuresis","ACTIVE_COMPARATOR","Participants randomized to this study arm will have their diuresis clinically guided by standard of care. They will also have five point ultrasound but the results will not inform their diuresis.",[13,14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Five-point ultrasound","In-person study visits will be done on initial evaluation and then at least every 48 hours, during which serial five-point ultrasound will be performed to assess venous congestion. Each visit will not be at strict intervals; a reasonable time window is every 48 hours +\u002F- 12 hours. Ultrasound may be performed more frequently if clinically indicated. During these visits or between them, ultrasound of the heart may additionally be performed. Each visit will last between 10 and 60 minutes.",[9,16],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Standard of care","Standard of care will most likely include radiographic investigations (chest X-ray, chest CT), laboratory evaluation (complete blood counts, metabolic panel, B-type natriuretic peptide, high-sensitivity troponin, electrolytes, renal function, urine testing), volume status, and cardiopulmonary physical exam.",[9,16],[32,36],{"name":33,"affiliation":34,"role":35},"Deepa M Gopal, MD","Boston Medical Center, Cardiovascular Medicine\u002FHeart Failure","PRINCIPAL_INVESTIGATOR",{"name":37,"affiliation":38,"role":35},"Aala Jaberi, MD","Boston Medical Center, Nephrology Section",[40,44],{"name":33,"role":41,"phone":42,"phoneExt":26,"email":43},"CONTACT","617 638 8717","dmgopal@bu.edu",{"name":45,"role":41,"phone":26,"phoneExt":26,"email":46},"Om Kothari, MD","om.kothari@bmc.org",[48],{"facility":5,"status":26,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Boston","Massachusetts","02118","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-71.05977,42.35843,{"lat":58,"lon":57},[61,63],{"name":33,"role":41,"phone":62,"phoneExt":26,"email":43},"617-638-8717",{"name":45,"role":41,"phone":26,"phoneExt":26,"email":64},"Om.Kothari@bmc.org",{"type":66,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100600379","boston-medical-center-ultrasound-decongestion-study-in-heart-failure-100600379",false,"NCT07096726","Boston Medical Center Ultrasound Decongestion Study in Heart Failure","Boston Medical Center Ultrasound Decongestion Study","BUDS-HF","Inclusion Criteria:\n\n* Patient with a primary diagnosis of acute on chronic decompensated heart failure who is admitted to inpatient or presents to the outpatient Boston Medical Center (BMC) Heart Failure Infusion clinic for decongestion treatment.\n* Willing and able to receive short abdominal and thoracic ultrasounds throughout hospitalization\n* Patients with right and\u002For left ventricular failure\n\nExclusion Criteria:\n\n* Hemodynamic instability defined as systolic blood pressure \\\u003C85 mmHg or mean arterial pressure \\\u003C60 mm Hg for greater than 24 hours duration\n* Abdominal surgery in the past 1 month\n* Significant acute or chronic liver disease\n* End stage renal disease on dialysis\n* Advanced chronic kidney disease (CKD) \\[Stage V CKD with glomerular filtration rate (GFR) \\\u003C15\\] to exclude renal vein doppler ultrasound\n* Severe acute kidney injury (AKI) or requiring renal replacement therapy\n* Known abdominal thrombus in the inferior vena cava (IVC) or portal vein\n* Acute myocarditis\n* Acute valvular disease\n* Acute type 1 myocardial infarction\n* Medical condition precluding abdominal ultrasound due to significant discomfort or pain\n* Adults not able to provide consent (a simple teach back method of key aspects discussed in consent form will be utilized to verify if patient is able to adequately provide informed consent)","ALL","18 Years",{"count":78,"type":79},200,"ESTIMATED","INTERVENTIONAL",[82],"NA","The purpose of this study is to analyze the utility of a novel five-point ultrasound as a predictor of volume overload in diverse patients who are admitted with volume overload\u002Fcongestive heart failure (CHF) exacerbation at Boston Medical Center (BMC), the largest safety-net hospital in New England. Current standard of care (SOC) involves the utilization of laboratory markers and physical exam, which is often inconsistent and equivocal. The investigators will assess will assess if ultrasound-assisted diuresis reduces recurrent episodes of volume overload\u002Fdecompensated heart failure.",[85,86],"Congestive Heart Failure","Volume Overload",[88,89,90,91],"Venous Excess Ultrasound (VExUS)","Ultrasound-assisted diuresis","Heart Failure with Preserved Ejection Fraction (HFpEF)","Heart Failure with Reduced Ejection Fraction (HFrEF)","NOT_YET_RECRUITING","2026-06-29",{"date":95,"type":96},"2026-06-30","ACTUAL",{"date":98,"type":79},"2026-09",{"date":100,"type":79},"2027-12",{"name":5,"class":6},1]