[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592307":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":14,"centralContacts":19,"locations":29,"responsibleParty":49,"collaborators":10,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Universitaire Ziekenhuizen KU Leuven","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Children with spastic cerebral palsy",null,"Children between 2 years and 16 years old",{"label":13,"type":10,"description":11,"interventionNames":10},"Typically developing children",[15],{"name":16,"affiliation":17,"role":18},"Kaat Desloovere, Prof.dr.","Department of Rehabilitation Sciences, KU Leuven, Belgium","PRINCIPAL_INVESTIGATOR",[20,25],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Charlotte Lambrechts","CONTACT","+32489421264","charlotte.lambrechts@kuleuven.be",{"name":26,"role":22,"phone":27,"phoneExt":10,"email":28},"Julie Stegen","+32477273954","julie.stegen@kuleuven.be",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"UZ Leuven","RECRUITING","Leuven","Vlaams-Brabant","3000","Belgium","BE",{"type":39,"coordinates":40},"Point",[41,42],4.70093,50.87959,{"lat":42,"lon":41},[45],{"name":46,"role":22,"phone":47,"phoneExt":10,"email":48},"Kaat Desloovere, prof. dr.","+3216338009","kaat.desloovere@kuleuven.be",{"type":18,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Kaat Desloovere","Prof. dr.","100592307","botulinum-neurotoxin-for-children-with-cp-a-delicate-balance-between-clinical-benefits-and-muscular-harm-100592307",false,"NCT06991725","Botulinum Neurotoxin for Children With CP: a Delicate Balance Between Clinical Benefits and Muscular Harm","Botulinum Neurotoxin for Children With Cerebral Palsy: a Delicate Balance Between Clinical Benefits and Muscular Harm","Bo-Balance","\\- Children with spastic cerebral palsy\n\nInclusion criteria:\n\n* Children (boys\u002Fgirls) with congenital brain lesion, confirmed with neuro-imaging such as MRI\n* At high-risk for CP or diagnosed spastic type of CP\n* (Suspected) Gross Motor Function Classification Scale (GMFCS) Level I-III\n* Uni or bilateral involvement\n* Aged between 2-16 years\n\nExclusion criteria:\n\n* Presence of dyskinesia or ataxia\n* Severe co-morbidities (cognitive problems)\n* BTX treatment in the gastrocnemius in the past 10 months\n* Previous surgery at the investigated muscles.\n* Previous orthopedic or neurosurgery\n* Severe ankle deformities\n* Weight for height values \\>2SD or \\\u003C-2SD from mean\n\n  * Typically developing children\n\nInclusion criteria:\n\n• Aged between 2-16 years\n\nExclusion criteria:\n\n* History of neurological, orthopedic or muscular problems\n* Involvement in an elite or high-performance sporting program (Children performing the same sports for \\> 5 hours\u002Fweek will be excluded)",true,"ALL","2 Years","16 Years",{"count":65,"type":66},51,"ESTIMATED","OBSERVATIONAL","A cross-sectional design study will be carried out to explore the morphological muscle properties and alterations in muscle composition on a macroscopic level in children with spastic cerebral palsy (CP). Muscle composition will be assessed using quantitative Magnetic Resonance Imaging (qMRI) and shear wave elastography (SWE), while macroscopic muscle size properties will be evaluated through 'Three-dimensional freehand ultrasound (3DfUS).",[70],"Spastic Cerebral Palsy (sCP)",[72,73,74,75,76,77,78,79],"Spastic Cerebral Palsy","Muscle composition","3D freehand ultrasound","Shear wave elastography","Muscle morphology","Range of motion","Stiffness","Spasticity","2026-04-28",{"date":82,"type":83},"2026-04-29","ACTUAL",{"date":85,"type":83},"2025-02-03",{"date":87,"type":66},"2028-12",{"name":5,"class":6},1]