[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100414233":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":19,"locations":30,"responsibleParty":551,"collaborators":553,"id":561,"slug":562,"hasResults":563,"nctId":564,"briefTitle":565,"officialTitle":566,"acronym":567,"eligibilityCriteria":568,"healthyVolunteers":563,"sex":569,"minAge":570,"maxAge":7,"enrollmentInfo":571,"targetDuration":7,"studyType":574,"phases":7,"briefSummary":575,"conditions":576,"keywords":578,"overallStatus":33,"whyStopped":7,"lastUpdateSubmitDate":580,"lastUpdatePostDateStruct":581,"startDateStruct":584,"completionDateStruct":586,"leadSponsor":588,"locationsCount":589},{"fullName":5,"class":6},"Pierre Fabre Pharma GmbH","INDUSTRY",null,[9,15],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":13},"DRUG","Encorafenib","Observation of real-life treatment with encorafenib and cetuximab",[14],"Braftovi",{"type":10,"name":16,"description":12,"armGroupLabels":7,"otherNames":17},"Cetuximab",[18],"Erbitux",[20,26],{"name":21,"role":22,"phone":23,"phoneExt":24,"email":25},"Marion Schmoll","CONTACT","+4976115242627","0","marion.schmoll@iomedico.com",{"name":27,"role":22,"phone":28,"phoneExt":24,"email":29},"Frank Reichenbach, Dr. rer. nat","+4976145261846","frank.reichenbach@pierre-fabre.com",[31,45,53,62,70,82,91,96,105,113,121,129,137,147,156,165,173,181,190,194,202,205,213,222,227,233,242,250,258,263,271,279,287,295,303,311,319,327,335,343,351,360,368,376,385,394,403,411,420,428,432,441,450,455,463,468,473,478,483,487,494,502,507,514,518,525,529,533,540,547],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":7},"Clinic","RECRUITING","Braunau am Inn","Upper Austria","5280","Austria","AT",{"type":40,"coordinates":41},"Point",[42,43],13.04343,48.25628,{"lat":43,"lon":42},{"facility":32,"status":33,"city":46,"state":35,"zip":47,"country":37,"countryCode":38,"cosmosGeoPoint":48,"geoPoint":52,"contacts":7},"Linz","4010",{"type":40,"coordinates":49},[50,51],14.28611,48.30639,{"lat":51,"lon":50},{"facility":32,"status":33,"city":54,"state":55,"zip":56,"country":37,"countryCode":38,"cosmosGeoPoint":57,"geoPoint":61,"contacts":7},"Feldkirch","Voralberg","6807",{"type":40,"coordinates":58},[59,60],9.59734,47.23645,{"lat":60,"lon":59},{"facility":32,"status":33,"city":63,"state":7,"zip":64,"country":37,"countryCode":38,"cosmosGeoPoint":65,"geoPoint":69,"contacts":7},"Vienna","1090",{"type":40,"coordinates":66},[67,68],16.37208,48.20849,{"lat":68,"lon":67},{"facility":71,"status":33,"city":72,"state":73,"zip":74,"country":75,"countryCode":76,"cosmosGeoPoint":77,"geoPoint":81,"contacts":7},"Practice","Offenburg","Baden-Wurttemberg","77654","Germany","DE",{"type":40,"coordinates":78},[79,80],7.94495,48.47377,{"lat":80,"lon":79},{"facility":83,"status":33,"city":84,"state":73,"zip":85,"country":75,"countryCode":76,"cosmosGeoPoint":86,"geoPoint":90,"contacts":7},"Medical Care Centre","Ulm","89073",{"type":40,"coordinates":87},[88,89],9.99155,48.39841,{"lat":89,"lon":88},{"facility":32,"status":33,"city":84,"state":73,"zip":92,"country":75,"countryCode":76,"cosmosGeoPoint":93,"geoPoint":95,"contacts":7},"89081",{"type":40,"coordinates":94},[88,89],{"lat":89,"lon":88},{"facility":71,"status":33,"city":97,"state":98,"zip":99,"country":75,"countryCode":76,"cosmosGeoPoint":100,"geoPoint":104,"contacts":7},"Augsburg","Bavaria","86150",{"type":40,"coordinates":101},[102,103],10.89851,48.37154,{"lat":103,"lon":102},{"facility":71,"status":33,"city":106,"state":98,"zip":107,"country":75,"countryCode":76,"cosmosGeoPoint":108,"geoPoint":112,"contacts":7},"Donauwörth","86609",{"type":40,"coordinates":109},[110,111],10.7793,48.71804,{"lat":111,"lon":110},{"facility":32,"status":33,"city":114,"state":98,"zip":115,"country":75,"countryCode":76,"cosmosGeoPoint":116,"geoPoint":120,"contacts":7},"Erlangen","91054",{"type":40,"coordinates":117},[118,119],11.00783,49.59099,{"lat":119,"lon":118},{"facility":71,"status":33,"city":122,"state":98,"zip":123,"country":75,"countryCode":76,"cosmosGeoPoint":124,"geoPoint":128,"contacts":7},"München","81241",{"type":40,"coordinates":125},[126,127],13.46314,48.69668,{"lat":127,"lon":126},{"facility":71,"status":33,"city":130,"state":98,"zip":131,"country":75,"countryCode":76,"cosmosGeoPoint":132,"geoPoint":136,"contacts":7},"Würzburg","97080",{"type":40,"coordinates":133},[134,135],9.95121,49.79391,{"lat":135,"lon":134},{"facility":138,"status":33,"city":139,"state":140,"zip":141,"country":75,"countryCode":76,"cosmosGeoPoint":142,"geoPoint":146,"contacts":7},"Medical Car Centre","Aschaffenburg","Bayer","63739",{"type":40,"coordinates":143},[144,145],9.15214,49.97704,{"lat":145,"lon":144},{"facility":83,"status":33,"city":148,"state":149,"zip":150,"country":75,"countryCode":76,"cosmosGeoPoint":151,"geoPoint":155,"contacts":7},"Potsdam","Brandenburg","14467",{"type":40,"coordinates":152},[153,154],13.06566,52.39886,{"lat":154,"lon":153},{"facility":71,"status":33,"city":157,"state":158,"zip":159,"country":75,"countryCode":76,"cosmosGeoPoint":160,"geoPoint":164,"contacts":7},"Celle","Lower Saxony","29221",{"type":40,"coordinates":161},[162,163],10.08047,52.62264,{"lat":163,"lon":162},{"facility":83,"status":33,"city":166,"state":158,"zip":167,"country":75,"countryCode":76,"cosmosGeoPoint":168,"geoPoint":172,"contacts":7},"Goslar","38642",{"type":40,"coordinates":169},[170,171],10.42766,51.90425,{"lat":171,"lon":170},{"facility":71,"status":33,"city":174,"state":158,"zip":175,"country":75,"countryCode":76,"cosmosGeoPoint":176,"geoPoint":180,"contacts":7},"Göttingen","37073",{"type":40,"coordinates":177},[178,179],9.93228,51.53443,{"lat":179,"lon":178},{"facility":182,"status":33,"city":183,"state":158,"zip":184,"country":75,"countryCode":76,"cosmosGeoPoint":185,"geoPoint":189,"contacts":7},"Medical Practice","Hanover","30161",{"type":40,"coordinates":186},[187,188],9.73322,52.37052,{"lat":188,"lon":187},{"facility":71,"status":33,"city":183,"state":158,"zip":184,"country":75,"countryCode":76,"cosmosGeoPoint":191,"geoPoint":193,"contacts":7},{"type":40,"coordinates":192},[187,188],{"lat":188,"lon":187},{"facility":71,"status":33,"city":195,"state":158,"zip":196,"country":75,"countryCode":76,"cosmosGeoPoint":197,"geoPoint":201,"contacts":7},"Leer","26789",{"type":40,"coordinates":198},[199,200],7.461,53.23157,{"lat":200,"lon":199},{"facility":32,"status":33,"city":203,"state":158,"zip":204,"country":75,"countryCode":76,"cosmosGeoPoint":7,"geoPoint":7,"contacts":7},"Weißenfels","26121",{"facility":182,"status":33,"city":206,"state":158,"zip":207,"country":75,"countryCode":76,"cosmosGeoPoint":208,"geoPoint":212,"contacts":7},"Wilhelmshaven","26389",{"type":40,"coordinates":209},[210,211],8.10395,53.5476,{"lat":211,"lon":210},{"facility":71,"status":33,"city":214,"state":215,"zip":216,"country":75,"countryCode":76,"cosmosGeoPoint":217,"geoPoint":221,"contacts":7},"Rostock","Mecklenburg-Vorpommern","18057",{"type":40,"coordinates":218},[219,220],12.14049,54.0887,{"lat":220,"lon":219},{"facility":71,"status":33,"city":214,"state":215,"zip":223,"country":75,"countryCode":76,"cosmosGeoPoint":224,"geoPoint":226,"contacts":7},"18107",{"type":40,"coordinates":225},[219,220],{"lat":220,"lon":219},{"facility":32,"status":33,"city":214,"state":228,"zip":229,"country":75,"countryCode":76,"cosmosGeoPoint":230,"geoPoint":232,"contacts":7},"Melcklenburg-Vorpommern","18059",{"type":40,"coordinates":231},[219,220],{"lat":220,"lon":219},{"facility":32,"status":33,"city":234,"state":235,"zip":236,"country":75,"countryCode":76,"cosmosGeoPoint":237,"geoPoint":241,"contacts":7},"Aachen","North Rhine-Westphalia","52074",{"type":40,"coordinates":238},[239,240],6.08342,50.77664,{"lat":240,"lon":239},{"facility":32,"status":33,"city":243,"state":235,"zip":244,"country":75,"countryCode":76,"cosmosGeoPoint":245,"geoPoint":249,"contacts":7},"Bochum","44791",{"type":40,"coordinates":246},[247,248],7.21648,51.48165,{"lat":248,"lon":247},{"facility":71,"status":33,"city":251,"state":235,"zip":252,"country":75,"countryCode":76,"cosmosGeoPoint":253,"geoPoint":257,"contacts":7},"Bonn","53123",{"type":40,"coordinates":254},[255,256],7.09549,50.73438,{"lat":256,"lon":255},{"facility":32,"status":33,"city":251,"state":235,"zip":259,"country":75,"countryCode":76,"cosmosGeoPoint":260,"geoPoint":262,"contacts":7},"53127",{"type":40,"coordinates":261},[255,256],{"lat":256,"lon":255},{"facility":71,"status":33,"city":264,"state":235,"zip":265,"country":75,"countryCode":76,"cosmosGeoPoint":266,"geoPoint":270,"contacts":7},"Bottrop","46236",{"type":40,"coordinates":267},[268,269],6.9285,51.52392,{"lat":269,"lon":268},{"facility":32,"status":33,"city":272,"state":235,"zip":273,"country":75,"countryCode":76,"cosmosGeoPoint":274,"geoPoint":278,"contacts":7},"Essen","45147",{"type":40,"coordinates":275},[276,277],7.01228,51.45657,{"lat":277,"lon":276},{"facility":71,"status":33,"city":280,"state":235,"zip":281,"country":75,"countryCode":76,"cosmosGeoPoint":282,"geoPoint":286,"contacts":7},"Moers","47441",{"type":40,"coordinates":283},[284,285],6.6326,51.45342,{"lat":285,"lon":284},{"facility":83,"status":33,"city":288,"state":235,"zip":289,"country":75,"countryCode":76,"cosmosGeoPoint":290,"geoPoint":294,"contacts":7},"Mönchengladbach","41239",{"type":40,"coordinates":291},[292,293],6.44172,51.18539,{"lat":293,"lon":292},{"facility":83,"status":33,"city":296,"state":235,"zip":297,"country":75,"countryCode":76,"cosmosGeoPoint":298,"geoPoint":302,"contacts":7},"Mülheim","45468",{"type":40,"coordinates":299},[300,301],6.87967,51.43218,{"lat":301,"lon":300},{"facility":83,"status":33,"city":304,"state":235,"zip":305,"country":75,"countryCode":76,"cosmosGeoPoint":306,"geoPoint":310,"contacts":7},"Neuss","41462",{"type":40,"coordinates":307},[308,309],6.68504,51.19807,{"lat":309,"lon":308},{"facility":32,"status":33,"city":312,"state":235,"zip":313,"country":75,"countryCode":76,"cosmosGeoPoint":314,"geoPoint":318,"contacts":7},"Paderborn","33098",{"type":40,"coordinates":315},[316,317],8.75439,51.71905,{"lat":317,"lon":316},{"facility":83,"status":33,"city":320,"state":235,"zip":321,"country":75,"countryCode":76,"cosmosGeoPoint":322,"geoPoint":326,"contacts":7},"Porta Westfalica","32457",{"type":40,"coordinates":323},[324,325],8.91612,52.22961,{"lat":325,"lon":324},{"facility":71,"status":33,"city":328,"state":235,"zip":329,"country":75,"countryCode":76,"cosmosGeoPoint":330,"geoPoint":334,"contacts":7},"Stolberg","52222",{"type":40,"coordinates":331},[332,333],6.22595,50.77368,{"lat":333,"lon":332},{"facility":71,"status":33,"city":336,"state":235,"zip":337,"country":75,"countryCode":76,"cosmosGeoPoint":338,"geoPoint":342,"contacts":7},"Troisdorf","53840",{"type":40,"coordinates":339},[340,341],7.14968,50.80901,{"lat":341,"lon":340},{"facility":32,"status":33,"city":344,"state":235,"zip":345,"country":75,"countryCode":76,"cosmosGeoPoint":346,"geoPoint":350,"contacts":7},"Wuppertal","42283",{"type":40,"coordinates":347},[348,349],7.14816,51.25627,{"lat":349,"lon":348},{"facility":71,"status":33,"city":352,"state":353,"zip":354,"country":75,"countryCode":76,"cosmosGeoPoint":355,"geoPoint":359,"contacts":7},"Bad Kreuznach","Rhineland-Palatinate","55543",{"type":40,"coordinates":356},[357,358],7.86713,49.8414,{"lat":358,"lon":357},{"facility":71,"status":33,"city":361,"state":353,"zip":362,"country":75,"countryCode":76,"cosmosGeoPoint":363,"geoPoint":367,"contacts":7},"Kaiserslautern","67655",{"type":40,"coordinates":364},[365,366],7.77161,49.443,{"lat":366,"lon":365},{"facility":71,"status":33,"city":369,"state":353,"zip":370,"country":75,"countryCode":76,"cosmosGeoPoint":371,"geoPoint":375,"contacts":7},"Worms","67547",{"type":40,"coordinates":372},[373,374],8.35916,49.63278,{"lat":374,"lon":373},{"facility":32,"status":33,"city":377,"state":378,"zip":379,"country":75,"countryCode":76,"cosmosGeoPoint":380,"geoPoint":384,"contacts":7},"Saarbrücken","Saarland","66113",{"type":40,"coordinates":381},[382,383],7.00982,49.23262,{"lat":383,"lon":382},{"facility":71,"status":33,"city":386,"state":387,"zip":388,"country":75,"countryCode":76,"cosmosGeoPoint":389,"geoPoint":393,"contacts":7},"Dresden","Saxony","01307",{"type":40,"coordinates":390},[391,392],13.73832,51.05089,{"lat":392,"lon":391},{"facility":395,"status":33,"city":396,"state":387,"zip":397,"country":75,"countryCode":76,"cosmosGeoPoint":398,"geoPoint":402,"contacts":7},"Prctice","Naunhof","04683",{"type":40,"coordinates":399},[400,401],12.58827,51.2777,{"lat":401,"lon":400},{"facility":32,"status":33,"city":404,"state":387,"zip":405,"country":75,"countryCode":76,"cosmosGeoPoint":406,"geoPoint":410,"contacts":7},"Torgau","04860",{"type":40,"coordinates":407},[408,409],12.99617,51.56016,{"lat":409,"lon":408},{"facility":71,"status":33,"city":412,"state":413,"zip":414,"country":75,"countryCode":76,"cosmosGeoPoint":415,"geoPoint":419,"contacts":7},"Halle","Saxony-Anhalt","06110",{"type":40,"coordinates":416},[417,418],11.97947,51.48158,{"lat":418,"lon":417},{"facility":32,"status":33,"city":421,"state":413,"zip":422,"country":75,"countryCode":76,"cosmosGeoPoint":423,"geoPoint":427,"contacts":7},"Köthen","06366",{"type":40,"coordinates":424},[425,426],11.97093,51.75185,{"lat":426,"lon":425},{"facility":71,"status":33,"city":421,"state":413,"zip":422,"country":75,"countryCode":76,"cosmosGeoPoint":429,"geoPoint":431,"contacts":7},{"type":40,"coordinates":430},[425,426],{"lat":426,"lon":425},{"facility":32,"status":33,"city":433,"state":434,"zip":435,"country":75,"countryCode":76,"cosmosGeoPoint":436,"geoPoint":440,"contacts":7},"Flensburg","Schleswig-Holstein","24939",{"type":40,"coordinates":437},[438,439],9.43722,54.78805,{"lat":439,"lon":438},{"facility":32,"status":33,"city":442,"state":443,"zip":444,"country":75,"countryCode":76,"cosmosGeoPoint":445,"geoPoint":449,"contacts":7},"Eisenach","Thuringia","99817",{"type":40,"coordinates":446},[447,448],10.31522,50.9807,{"lat":448,"lon":447},{"facility":451,"status":33,"city":139,"state":7,"zip":7,"country":75,"countryCode":76,"cosmosGeoPoint":452,"geoPoint":454,"contacts":7},"Hospital",{"type":40,"coordinates":453},[144,145],{"lat":145,"lon":144},{"facility":83,"status":33,"city":456,"state":7,"zip":457,"country":75,"countryCode":76,"cosmosGeoPoint":458,"geoPoint":462,"contacts":7},"Berlin","10407",{"type":40,"coordinates":459},[460,461],13.41053,52.52437,{"lat":461,"lon":460},{"facility":71,"status":33,"city":456,"state":7,"zip":464,"country":75,"countryCode":76,"cosmosGeoPoint":465,"geoPoint":467,"contacts":7},"10707",{"type":40,"coordinates":466},[460,461],{"lat":461,"lon":460},{"facility":71,"status":33,"city":456,"state":7,"zip":469,"country":75,"countryCode":76,"cosmosGeoPoint":470,"geoPoint":472,"contacts":7},"10715",{"type":40,"coordinates":471},[460,461],{"lat":461,"lon":460},{"facility":32,"status":33,"city":456,"state":7,"zip":474,"country":75,"countryCode":76,"cosmosGeoPoint":475,"geoPoint":477,"contacts":7},"12559",{"type":40,"coordinates":476},[460,461],{"lat":461,"lon":460},{"facility":479,"status":33,"city":456,"state":7,"zip":7,"country":75,"countryCode":76,"cosmosGeoPoint":480,"geoPoint":482,"contacts":7},"Private Practice",{"type":40,"coordinates":481},[460,461],{"lat":461,"lon":460},{"facility":479,"status":33,"city":386,"state":7,"zip":7,"country":75,"countryCode":76,"cosmosGeoPoint":484,"geoPoint":486,"contacts":7},{"type":40,"coordinates":485},[391,392],{"lat":392,"lon":391},{"facility":451,"status":33,"city":488,"state":7,"zip":7,"country":75,"countryCode":76,"cosmosGeoPoint":489,"geoPoint":493,"contacts":7},"Esslingen am Neckar",{"type":40,"coordinates":490},[491,492],9.30473,48.73961,{"lat":492,"lon":491},{"facility":71,"status":33,"city":495,"state":7,"zip":496,"country":75,"countryCode":76,"cosmosGeoPoint":497,"geoPoint":501,"contacts":7},"Hamburg","10259",{"type":40,"coordinates":498},[499,500],9.99302,53.55073,{"lat":500,"lon":499},{"facility":71,"status":33,"city":495,"state":7,"zip":503,"country":75,"countryCode":76,"cosmosGeoPoint":504,"geoPoint":506,"contacts":7},"20259",{"type":40,"coordinates":505},[499,500],{"lat":500,"lon":499},{"facility":479,"status":33,"city":508,"state":7,"zip":7,"country":75,"countryCode":76,"cosmosGeoPoint":509,"geoPoint":513,"contacts":7},"Heidelberg",{"type":40,"coordinates":510},[511,512],8.69079,49.40768,{"lat":512,"lon":511},{"facility":479,"status":33,"city":195,"state":7,"zip":7,"country":75,"countryCode":76,"cosmosGeoPoint":515,"geoPoint":517,"contacts":7},{"type":40,"coordinates":516},[199,200],{"lat":200,"lon":199},{"facility":479,"status":33,"city":519,"state":7,"zip":7,"country":75,"countryCode":76,"cosmosGeoPoint":520,"geoPoint":524,"contacts":7},"Lübeck",{"type":40,"coordinates":521},[522,523],10.68729,53.86893,{"lat":523,"lon":522},{"facility":479,"status":33,"city":396,"state":7,"zip":7,"country":75,"countryCode":76,"cosmosGeoPoint":526,"geoPoint":528,"contacts":7},{"type":40,"coordinates":527},[400,401],{"lat":401,"lon":400},{"facility":479,"status":33,"city":72,"state":7,"zip":7,"country":75,"countryCode":76,"cosmosGeoPoint":530,"geoPoint":532,"contacts":7},{"type":40,"coordinates":531},[79,80],{"lat":80,"lon":79},{"facility":479,"status":33,"city":534,"state":7,"zip":7,"country":75,"countryCode":76,"cosmosGeoPoint":535,"geoPoint":539,"contacts":7},"Oldenburg in Holstein",{"type":40,"coordinates":536},[537,538],10.89043,54.29498,{"lat":538,"lon":537},{"facility":479,"status":33,"city":541,"state":7,"zip":7,"country":75,"countryCode":76,"cosmosGeoPoint":542,"geoPoint":546,"contacts":7},"Schorndorf",{"type":40,"coordinates":543},[544,545],9.52721,48.80537,{"lat":545,"lon":544},{"facility":479,"status":33,"city":130,"state":7,"zip":7,"country":75,"countryCode":76,"cosmosGeoPoint":548,"geoPoint":550,"contacts":7},{"type":40,"coordinates":549},[134,135],{"lat":135,"lon":134},{"type":552,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[554,556,558],{"name":555,"class":6},"iOMEDICO AG",{"name":557,"class":6},"Pierre Fabre Pharma AG",{"name":559,"class":560},"Pierre Fabre Pharma Austria","UNKNOWN","100414233","braf-inhibitor-encorafenib-and-cetuximab-real-life-investigation-of-next-generation-crc-treatment-100414233",false,"NCT04673955","BRAF Inhibitor Encorafenib And Cetuximab Real Life Investigation of Next Generation CRC Treatment","Encorafenib and Cetuximab in Patients With Metastatic, BRAFV600E-mutated, Colorectal Carcinoma: a Multi-centric, Multi-national, Prospective, Longitudinal, Non-interventional Study in Germany, Austria and Switzerland","BERING-CRC","Inclusion Criteria:\n\n* Written informed consent of the patient with regard to the pseudonymized documentation of his\u002Fher data in the frame of this non-interventional study\n* Legally capable patient ≥ 18 years of age (no upper limit)\n* Metastatic colorectal carcinoma with BRAFV600E-mutation, pretreated with systemic therapy\n* Decision was taken to treat the patient with the doublet therapy (encorafenib and cetuximab) in accordance with the current SmPC and by prescription; this decision was taken prior to and independent from the inclusion into the study;\n* Treatment with the doublet therapy (encorafenib plus cetuximab) has been started ≤ 3 months prior to providing written informed consent for this study or is planned to be started in the near future.\n\nExclusion Criteria:\n\n* More than 2 prior systemic regimens in the metastatic setting (adjuvant systemic therapy with relapse ≤ 6 months will be counted as metastatic treatment line; maintenance treatment will not be counted as separate metastatic treatment line)\n* Prior treatment with any RAF-inhibitor or MEK-inhibitor.\n* Presence of any contraindication with regard to the doublet therapy (encorafenib plus cetuximab) as specified in the corresponding SmPCs\n* Current or upcoming participation in an interventional clinical trial\n* Current or upcoming systemic treatment of any other tumor than metastatic colorectal carcinoma\n* Prisoners or persons who are compulsorily detained (involuntarily incarcerated).","ALL","18 Years",{"count":572,"type":573},500,"ESTIMATED","OBSERVATIONAL","The presence of a BRAFV600E mutation is a marker of poor prognosis in patients with mCRC and associated with a median overall survival (mOS) of approximately 12 to 14 months compared to 20 to 25 months for patients with BRAF wild-type tumours. After 1st line therapy, treatment outcomes with standard therapy are poor in patients with BRAF-mutated mCRC, with response rates (ORR) of ≤ 11%, a median progression-free survival (mPFS) between 1.8 and 2.8 months, and a mOS between 4.1 and 6.2 months. Failure to achieve adequate survival outcomes with standard treatment regimens in patients with BRAF-mutated mCRC has encouraged efforts to combine multiple targeted therapies: With 665 randomized patients, the BEACON CRC trial represents the largest trial and is currently the only phase III study in patients with BRAFV600E-mutant mCRC.\n\nBERING CRC - designed as a prospective (allowing initial retrospective documentation), longitudinal, non-interventional study - will investigate the real-world effectiveness, quality of life, safety and tolerability of encorafenib and cetuximab in BRAFV600E-mutant mCRC patients, who have received prior systemic therapy. Data from this study will contribute to a deeper understanding and characterization to the everyday use of encorafenib and cetuximab in a broader patient population in the German, Austrian, and Swiss routine setting.",[577],"Metastatic Colorectal Carcinoma",[579],"BRAFV600E mutation","2022-09-27",{"date":582,"type":583},"2022-09-29","ACTUAL",{"date":585,"type":583},"2020-09-03",{"date":587,"type":573},"2027-01",{"name":5,"class":6},70]