[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100384501":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":26,"locations":36,"responsibleParty":54,"collaborators":56,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":20,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":20,"overallStatus":38,"whyStopped":20,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"VA Office of Research and Development","FED",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Reaching with TMS","EXPERIMENTAL","All participants enrolled in this group will receive TMS while performing reaching movements in a robotic system.",[13],"Device: Transcranial Magnetic Stimulation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Transcranial Magnetic Stimulation","Paired pulse transcranial magnetic stimulation",[9],null,[22],{"name":23,"affiliation":24,"role":25},"George F. Wittenberg, MD PhD","VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA","PRINCIPAL_INVESTIGATOR",[27,32],{"name":28,"role":29,"phone":30,"phoneExt":20,"email":31},"Amy Boos","CONTACT","(412) 648-4179","amy.boos2@va.gov",{"name":33,"role":29,"phone":34,"phoneExt":20,"email":35},"George F Wittenberg, MD PhD","(412) 360-6185","George.Wittenberg@va.gov",[37],{"facility":24,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Pittsburgh","Pennsylvania","15240","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-79.99589,40.44062,{"lat":48,"lon":47},[51,52,53],{"name":33,"role":29,"phone":34,"phoneExt":20,"email":35},{"name":28,"role":29,"phone":30,"phoneExt":20,"email":31},{"name":23,"role":25,"phone":20,"phoneExt":20,"email":20},{"type":55,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[57,59],{"name":58,"class":6},"VA Pittsburgh Healthcare System",{"name":60,"class":61},"University of Pittsburgh","OTHER","100384501","brain-connections-for-arm-movement-after-stroke-100384501",false,"NCT04286516","Brain Connections for Arm Movement After Stroke","Brain Areas That Control Reaching Movements After Stroke: Task-relevant Connectivity and Movement-synchronized Brain Stimulation","CAM","Inclusion Criteria:\n\nInclusion Criteria (control participants):\n\n* Be 45-90 years of age\n* Have adequate language and neurocognitive function to participate in training and testing\n* Be medically stable to participate in the study\n* Be English speaking\n\nInclusion Criteria (participants with stroke):\n\n* Be 45-90 years of age\n* Clinically defined, unilateral, hemiparetic stroke with radiologic exclusion of other possible diagnosis\n* Stroke onset at least 6 months before enrollment\n* Subcortical stroke (ex: internal capsule, deep white matter of posterior frontal lobe)\n* Present with mild to moderate arm dysfunction\n* Be medically stable to participate in the study\n* Be English speaking\n\nExclusion Criteria:\n\n(for both groups)\n\n* Unable to give informed consent\n* Have a serious complicating medical illness that would preclude participation\n* Contractures or orthopedic problems limiting range of joint motion in the potential study arm or other impairments that would interfere with the study activities\n* Visual loss such that the subject would not be able to see the test patterns on the robot computer monitor\n* Unable to comply with requirements of the study\n* Enrollment in another greater-than-minimal risk study\n* Presence of medical condition or implant that prevents safe administration of TMS or MRI\n* Pregnancy",true,"ALL","45 Years","90 Years",{"count":75,"type":76},76,"ESTIMATED","INTERVENTIONAL",[79],"NA","The purpose of this study is to use Transcranial Magnetic Stimulation (TMS) while subjects are making reaching movements in a robotic arm device in order to discover how different brain areas control movement before and after stroke and when these brain areas are most sensitive to TMS.",[82,83,84,85,86],"Stroke","Brain Disease","Central Nervous System Diseases","Nervous System Diseases","Cardiovascular Diseases","2026-05-28",{"date":89,"type":90},"2026-06-02","ACTUAL",{"date":92,"type":90},"2020-01-10",{"date":94,"type":76},"2027-06-01",{"name":5,"class":6},1]