[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637689":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":23,"locations":32,"responsibleParty":47,"collaborators":50,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":62,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":7,"studyType":74,"phases":7,"briefSummary":75,"conditions":76,"keywords":81,"overallStatus":35,"whyStopped":7,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Johannes Kepler University of Linz","OTHER",null,[9,13,16,19],{"name":10,"affiliation":11,"role":12},"Raimund Kleiser, PD Dr.","Neuroimaging Sciences and Support Center ,Clinical Institute for Neurosciences, Institute of Neuroradiology, Kepler Unisversity Hospital Linz, Johannes Kepler University","STUDY_CHAIR",{"name":14,"affiliation":15,"role":12},"Andreas Gruber, Full Professor","Head of Clinical Institute for Neurosciences, Head of the Departmend of Neurosurgery, Kepler Unisversity Hospital Linz, Johannes Kepler University",{"name":17,"affiliation":18,"role":12},"Hans Geinitz, Professor","Head of Department of Radiation Oncology, Clinical Institute for Neurosciences",{"name":20,"affiliation":21,"role":22},"Michael Sonnberger, MD","Head of Institute of Neuroradiology, Kepler University Hospital Linz, Johannes Kepler University","PRINCIPAL_INVESTIGATOR",[24,28],{"name":10,"role":25,"phone":26,"phoneExt":7,"email":27},"CONTACT","+43 5 7680 87 - 26701","raimund.kleiser@kepleruniklinikum.at",{"name":29,"role":25,"phone":30,"phoneExt":7,"email":31},"Mario Scheweder, MSc","+43 50 344 27125","mario.scheweder@kepleruniklinikum.at",[33],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":7},"Kepler University Hospital","RECRUITING","Linz","Upper Austria","4020","Austria","AT",{"type":42,"coordinates":43},"Point",[44,45],14.28611,48.30639,{"lat":45,"lon":44},{"type":22,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Michael Sonnberger","Head of Institute of Neuroradiology, Kepler University Hospital, Johannes Kepler University, Linz",[51,54,56,58],{"name":52,"class":53},"Clinical Research Institute for Neurosciences, JKU Linz, Austria","UNKNOWN",{"name":55,"class":53},"Institute of Neuroradiology, Kepler University Hospital, Johannes Kepler University, Lin",{"name":57,"class":53},"Department of Neurosurgery, Kepler University Hospital, Johannes Kepler University Linz",{"name":59,"class":53},"Department of Radiation Oncology, Ordensklinikum Linz, Barmherzige Schwestern, Linz, Austria","100637689","brain-connectivity-changes-in-glioma-patients-during-treatment-100637689",false,"NCT07612917","Brain Connectivity Changes in Glioma Patients During Treatment","Functional Reorganization and Connectivity in Glioma Patients During the Therapeutic Trajectory","GliRecon","Inclusion Criteria:\n\n* Patients with diffuse gliomas (WHO grade 2-4).\n* Age \\>18 years and \\\u003C65 years.\n* Written participant information and informed consent provided and signed.\n* Signed informed consent for functional magnetic resonance imaging (fMRI).\n\nExclusion Criteria:\n\n* Age \\\u003C18 years or \\>65 years.\n* Pregnancy.\n* Contraindications to MRI, including but not limited to:\n\n  * Active medical implants (e.g., pain pump, defibrillator, cardiac pacemaker),\n  * Orthodontic braces,\n  * Metallic tattoos,\n  * Non-removable piercings,\n  * Known metallic foreign bodies,\n  * Claustrophobia.\n* Cerebral metastases from secondary (non-primary) tumors.\n* Absence of baseline BOLD functional MRI and\u002For baseline neurocognitive assessment.\n* Failure to provide written participant information and informed consent.\n* Karnofsky Performance Status (KPS) \\\u003C60, unless feasibility of clinical-psychological testing and BOLD fMRI is confirmed by the investigator in consultation with clinical psychology, radiology staff, and the patient.","ALL","18 Years","64 Years",{"count":72,"type":73},20,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to better understand how the brain changes during the treatment of glioma. In particular, the study looks at changes in important brain areas that are responsible for functions such as movement, language, or sensation, as well as the nerve fiber pathways that connect these areas.\n\nThe main question this study aims to answer is:\n\nHow do important brain areas and their connections adapt and reorganize over the course of glioma treatment?\n\nPatients with glioma will undergo repeated brain imaging examinations as part of their regular medical care. These images will be analyzed over time to observe changes in brain activity and structure during different stages of therapy.\n\nBy studying these changes, researchers hope to gain new insights into the brain's ability to adapt (neuroplasticity) throughout the entire course of glioma treatment.",[77,78,79,80],"Glioma (Any Grade) in the Brain","Gliomas, Malignant","fMRI Research","Neurocognitive Function",[82,83,84,85,86],"Glioma,","Magnetic Resonance Imaging, Functional","Brain Mapping","Neural Plasticity","Cognition","2026-05-28",{"date":89,"type":90},"2026-05-29","ACTUAL",{"date":92,"type":73},"2026-05",{"date":94,"type":73},"2029-12",{"name":5,"class":6},1]