[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100514975":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":57,"collaborators":26,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":26,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":26,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"University of Kansas Medical Center","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Weight Loss","EXPERIMENTAL","* Follow a reduced calorie diet daily for 12 months.\n* Attend monthly behavioral counseling\u002Feducation",[13,14],"Behavioral: Diet","Behavioral: Health Education",{"label":16,"type":17,"description":18,"interventionNames":19},"General Health Education Control","ACTIVE_COMPARATOR","\\- Attend monthly health education sessions about general health.",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Diet","A reduced calorie diet which uses frozen meals purchased at the store and focuses on increasing fruits and vegetables associated with brain health.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Health Education","Monthly health education sessions delivered remotely.",[16,9],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Lauren Ptomey, PhD","CONTACT","913-588-7982","lptomey@kumc.edu",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Jessica Danon","785-764-3574","jdanon@kumc.edu",[42],{"facility":5,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Kansas City","Kansas","66160","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-94.62746,39.11417,{"lat":53,"lon":52},[56],{"name":33,"role":34,"phone":26,"phoneExt":26,"email":26},{"type":58,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100514975","brain-outcomes-with-lifestyle-change-in-down-syndrome-100514975",false,"NCT05985486","Brain Outcomes With Lifestyle Change in Down Syndrome","The Impact of Weight Loss on Alzheimer's Disease Risk in Adults With Down Syndrome","BOLD","Inclusion Criteria:\n\n* Diagnosis of Down syndrome\n* BMI of 25 to 50 kg\u002Fm2\n* Ability to communicate through spoken language.\n* Ability to come to the University of Kansas Medical Center 3 times across 1 year for outcomes testing\n* Living at home with a parent\u002Fguardian, or in a supported living environment with a caregiver who assists with food shopping, meal planning, and meal preparation and agrees to serve as a study partner including providing transportation to our facilities for study assessments.\n\nExclusion Criteria:\n\n* Diagnosis of dementia\n* Insulin dependent diabetes\n* Participation in a weight management program involving diet or physical activity in the past 6 mos.\n* Dairy allergy\n* Serious medical risk (e.g., cancer, recent heart attack, stroke, pregnancy, angioplasty)\n* Unwilling to be randomized\n* Contraindications for MRI, including metal implants or devices incompatible with MRI such as pacemakers, claustrophobia, and inability to lay in a supine position\n* Use of GLP-1 medications\n* Use of anti-amyloid medications","ALL","18 Years","64 Years",{"count":71,"type":72},81,"ESTIMATED","INTERVENTIONAL",[75],"NA","The goal of this study is to determine if weight loss or changes in dietary intake can help prevent of delay adults with Down syndrome from developing Alzheimer's Disease\n\nAdults with Down syndrome without dementia will be randomized to either a weight loss group or a general health education control group. The weight loss group will be asked to follow a reduced energy diet, attend monthly education sessions delivered remotely and self-monitor diet and body weight using commercially available web-based applications. The control group will be asked to attend remotely delivered monthly education sessions on general health education topics.\n\nAll participants will come to the University of Kansas Medical Center, 3 times across 12 months for a blood draw, cognitive testing, a MRI, assessment of height and weight, and assessment of diet intake.",[78,79,80],"Down Syndrome","Alzheimer Disease","Obesity","2026-03-09",{"date":83,"type":84},"2026-03-11","ACTUAL",{"date":86,"type":84},"2024-10-22",{"date":88,"type":72},"2027-09-30",{"name":5,"class":6},1]