[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100507900":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":34,"responsibleParty":53,"collaborators":10,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":64,"maxAge":10,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":76,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with acute brain injuries when a contrast ultrasound imaging is requested by the physician",null,"Contrast-enhanced ultrasound perfusion imaging (PerCEUS)",[13],"Diagnostic Test: Measuring contrast-enhanced ultrasound perfusion with phase inversion harmonic imaging",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Measuring contrast-enhanced ultrasound perfusion with phase inversion harmonic imaging","Contrast-enhanced ultrasound perfusion imaging (PerCEUS) will be performed by a dedicated study team. The transcranial color duplex sonography will be performed with a 1-5 MHz dynamic sector array (S5-1) from a Philips Epiq 7 ultrasound machine (Philips Healthcare, Andover, MA). The field-of-view will be set to an imaging depth of 150 mm in a sector angle of 90°. The imaging plane will be then tilted to the diencephalic, in which the frontal horns of the side ventricles and the third ventricle serve as landmarks and where the anterior and posterior middle cerebral artery (MCA) territory and the basal ganglia (BG) as region of interest could be identified without artefacts from major vessels. High mechanical index bolus imaging will be performed from the sanest side of the head. Data acquisition of 45 seconds will be recorded immediately after the beginning of the contrast ultrasound imaging, using a mechanical index (MI) setting of 1.1 and a frame rate of 33 Hz.",[9],[21],{"name":22,"affiliation":23,"role":24},"Romain BARTHELEMY, MD","AP-HP Lariboisière Hospital, Department of Anaesthesia and Intensive Care","PRINCIPAL_INVESTIGATOR",[26,30],{"name":22,"role":27,"phone":28,"phoneExt":10,"email":29},"CONTACT","+33 (0)1 49 95 85 15","romain.barthelemy@aphp.fr",{"name":31,"role":27,"phone":32,"phoneExt":10,"email":33},"Benjamin Glenn CHOUSTERMAN, MD PhD","+33 (0)1 49 95 85 18","benjamin.chousterman@aphp.fr",[35],{"facility":36,"status":37,"city":38,"state":10,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Lariboisière Hospital","RECRUITING","Paris","75010","France","FR",{"type":43,"coordinates":44},"Point",[45,46],2.3488,48.85341,{"lat":46,"lon":45},[49,51],{"name":22,"role":27,"phone":50,"phoneExt":10,"email":29},"+33149958515",{"name":31,"role":27,"phone":52,"phoneExt":10,"email":33},"+33149958518",{"type":54,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100507900","brain-perfusion-evaluation-by-contrast-enhanced-ultrasound-100507900",false,"NCT05893407","Brain PERfusion Evaluation by Contrast-Enhanced UltraSound","Quantification of Cerebral Perfusion at the Patient's Bedside When Performing Contrast-enhanced Ultrasound in Neurointensive Care Patients","PerCEUS","Inclusion Criteria:\n\n* Age ≥18\n* Intensive care unit admission for acute brain injury\n* Proven acute brain injury by CT and\u002For MRI\n* Requiring a contrast ultrasound imaging\n* Informed consent of patient or relative\n\nExclusion Criteria:\n\n* Pregnancy\n* Not sufficient temporal window\n* Contraindications to Sonovue ® : acute coronary syndromes, severe ischemic heart disease (requiring revascularization), pulmonary arterial hypertension \\> 90 mmHg, right-left shunt, ARDS, dobutamine's use, known allergy or adverse reaction to Sonovue®\n* Patient on State Medical Assistance","ALL","18 Years",{"count":66,"type":67},60,"ESTIMATED","OBSERVATIONAL","The objective of the study is to assess brain tissue perfusion by contrast-enhanced ultrasound perfusion imaging (PerCEUS) in acute brain injuries. More precisely, it aims :\n\n* to evaluate the heterogeneity of brain perfusion and thus diagnose brain tissue hypoperfusion with contrast-enhanced ultrasound.\n* to correlate contrast-enhanced ultrasound with perfusion measurements by usual multimodal monitoring.",[71,72,73,74,75],"Cerebral Hemorrhage","Subarachnoid Hemorrhage","Ischemic Stroke","Cerebrovascular Circulation","Perfusion",[77,78,79,80,81,82,83,84,85,86,87,88,89,90],"Brain perfusion","Cerebral blood flow","Diagnostic imaging","Ultrasonography Doppler","Doppler ultrasound","Transcranial Doppler","Contrast enhanced ultrasound","Contrast-enhanced ultrasonography","Contrast ultrasound","Ultrasound perfusion imaging","Ultrasound contrast agent","Intra-cranial pressure","Intracerebral hematoma","Neurocritical care","2025-06-16",{"date":93,"type":94},"2025-06-19","ACTUAL",{"date":96,"type":94},"2023-07-21",{"date":98,"type":67},"2025-07",{"name":5,"class":6},1]