[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623769":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":35,"centralContacts":40,"locations":50,"responsibleParty":74,"collaborators":30,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":30,"eligibilityCriteria":83,"healthyVolunteers":79,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":30,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":102,"overallStatus":53,"whyStopped":30,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"Universiti Malaysia Sabah","OTHER",[8,15,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Active tDCS + AOT","EXPERIMENTAL","Participants will receive anodal transcranial direct current stimulation (tDCS) at 2 mA for 20 minutes combined with action observation therapy (AOT) for 10 sessions over 2 weeks at an outpatient clinic. During tDCS delivery, participants will observe first-person perspective videos of hand motor tasks and practice the observed movements. Following the clinic phase, participants will continue AOT practice at home for 30 minutes once daily for 8 weeks.",[13,14],"Other: tDCS","Other: Action Observation Therapy (AOT)",{"label":16,"type":17,"description":18,"interventionNames":19},"sham tDCS + AOT","PLACEBO_COMPARATOR","Sham tDCS group - apply sham anodal tDCS with a 30s ramp-up and 30s ramp-down, switching the current to 0mA without the participant's awareness.\n\nAdminister sham anodal tDCS for 20 minutes. Concurrently perform AOT for 30 minutes.",[14],{"label":21,"type":22,"description":23,"interventionNames":24},"tDCS only","ACTIVE_COMPARATOR","Administer active anodal tDCS for 20 minutes. Concurrently perform upper limb motor task actions with landscape video for 30 minutes.",[13],[26,31],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"tDCS","* Stimulation type: Anodal stimulation\n* Electrode size: 5x7cm\n* Stimulation target: C3\u002FC4 primary motor cortex (M1) based on the 10-20 international electroencephalography system\n* Stimulation intensity: 2 mA\n* Stimulation current density: 0.029-0.057 mA\u002Fcm2\n\nUse tDCS with two saline-soaked surface sponge electrodes (5x7cm) applied to the scalp, secured with a headband. Stimulation intensity is set to 2mA, with 30s ramping up at the start and 30s ramping down at the end of stimulation.",[9,21],null,{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Action Observation Therapy (AOT)","Participants watch selected videos based on muscle grading of triceps, which include functional movement patterns and daily activity tasks of the upper limb. These videos are presented through a computer or mobile screen positioned at an appropriate distance from the participant to allow ample space for performing the required movements.",[9,16],[36],{"name":37,"affiliation":38,"role":39},"Fatimah Ahmedy","Universit Malaysia Sabah","PRINCIPAL_INVESTIGATOR",[41,46],{"name":42,"role":43,"phone":44,"phoneExt":30,"email":45},"Candace Goh Xiao Huey, Msc.","CONTACT","+60-162316345","candace@moh.gov.my",{"name":47,"role":43,"phone":48,"phoneExt":30,"email":49},"Fatimah Ahmedy, MRehabMed","+60-138805513","fatimahmedy@ums.edu.my",[51,67],{"facility":52,"status":53,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"Hospital Universiti Malaysia Sabah (HUMS)","RECRUITING","Kota Kinabalu","Sabah","88400","Malaysia","MY",{"type":60,"coordinates":61},"Point",[62,63],116.0724,5.9749,{"lat":63,"lon":62},[66],{"name":47,"role":43,"phone":48,"phoneExt":30,"email":49},{"facility":68,"status":69,"city":54,"state":55,"zip":70,"country":57,"countryCode":58,"cosmosGeoPoint":71,"geoPoint":73,"contacts":30},"Queen Elizabeth Hospital","ENROLLING_BY_INVITATION","88586",{"type":60,"coordinates":72},[62,63],{"lat":63,"lon":62},{"type":39,"investigatorFullName":75,"investigatorTitle":76,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Candace Goh Xiao Huey","Principal Investigator","100623769","brain-stimulation-combined-with-watching-hand-movements-to-improve-hand-recovery-in-chronic-stroke-100623769",false,"NCT07400939","Brain Stimulation Combined With Watching Hand Movements to Improve Hand Recovery in Chronic Stroke","Investigating The Neurophysiological Mechanisms Of Transcranial Direct Current Stimulation Combined With Action Observation Therapy On Hand Muscle Neuroplasticity in Chronic Stroke","Inclusion Criteria:\n\n* Adults aged 18 to 59 years\n* Single episode of unilateral stroke and weakness in hand muscles 6 to 24 months post-stroke\n* No excessive spasticity of the upper limb, defined as grade two or less on Modified Ashworth Scale\n\nExclusion Criteria:\n\n* Patients diagnosed with posterior circulation infarction\n* Unable to follow commands due to poor cognitive function\n* Unilateral neglect\n* Homonymous hemianopia\n* Other existing neurological disorders that lead to poor hand function\n* Grade four or five hand muscle strength.","ALL","18 Years","59 Years",{"count":88,"type":89},60,"ESTIMATED","INTERVENTIONAL",[92],"NA","This study investigates the neurophysiological mechanisms underlying the combined use of transcranial direct current stimulation (tDCS) and action observation therapy (AOT) for hand motor recovery in individuals with stroke. Background: While both tDCS and AOT have shown promise individually for stroke rehabilitation, the neural mechanisms of their combined effects remain unclear. Understanding these mechanisms could optimise rehabilitation protocols and improve functional outcomes. Intervention: Participants will receive 10 sessions of anodal tDCS over the ipsilesional motor cortex combined with AOT over two weeks in a clinical setting, followed by 8 weeks of home-based AOT practice. Control groups will receive tDCS alone or AOT alone. Neurophysiological changes will be assessed using motor evoked potentials (MEPs) to evaluate corticospinal excitability. Clinical hand function will be assessed using standardised outcome measures. Measurements: Assessments will be conducted at baseline, during intervention (week 2), and after the home practice phase (week 10) to evaluate neuroplastic changes. Significance: This study will provide mechanistic insights into how neuromodulation and observational learning interact to promote motor recovery, informing evidence-based rehabilitation strategies for stroke survivors in Malaysia and globally. Study Design: Randomised controlled trial with three parallel arms, recruiting 60 participants with chronic stroke from Sabah, Malaysia.",[95,27,96,97,98,99,100,101],"Stroke","Action Observation Therapy","Hand","Motor Evoked Potential","EMG","Neuroplasticity","Neurophysiological Assessment",[103,104,105,106,107],"stroke rehabilitation","transcranial direct current stimulation","action observation therapy","neuroplasticity","neurophysiological","2026-05-07",{"date":110,"type":111},"2026-05-12","ACTUAL",{"date":113,"type":111},"2026-04-01",{"date":115,"type":89},"2028-01-20",{"name":5,"class":6},2]