[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644705":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":20,"locations":21,"responsibleParty":42,"collaborators":20,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":20,"enrollmentInfo":55,"targetDuration":20,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":24,"whyStopped":20,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"McMaster University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention: EEG-triggered TMS","EXPERIMENTAL","The electroencephalography (EEG) triggered transcranial magnetic stimulation (TMS) arm involves receiving TMS timed to particular phases of EEG involved in working memory. TMS involves the delivery of brief current to the part of the brain that is involved in working memory. EEG involves placing 32 electrodes on the surface of then head and reading the brain's waves in real-time. TMS will be delivered to the part of the brain involved in working memory timed to EEG recorded brain waves",[13],"Device: EEG-triggered TMS",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","EEG-triggered TMS","This intervention involves delivering transcranial magnetic stimulation (TMS) to the dorsolateral prefrontal cortex (dlPFC) during working memory maintence timed to a specific electroencephalography (EEG) phase from the temporal cortex. The intervention is attempting to facilitate improved communication between the dlPFC and temporal cortex to improve working memory in people living with dementia.",[9],null,[22],{"facility":23,"status":24,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"Ivor Wynne Center","RECRUITING","Hamilton","Ontario","L8S 4L8","Canada","CA",{"type":31,"coordinates":32},"Point",[33,34],-79.84963,43.25011,{"lat":34,"lon":33},[37],{"name":38,"role":39,"phone":40,"phoneExt":20,"email":41},"Aimee Nleson, PhD","CONTACT","9055259140 Ext. 28053","nelsonaj@mcmaster.ca",{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Aimee Nelson","Professor","100644705","brain-wave-informed-non-invasive-brain-stimulation-improving-neural-networks-of-working-memory-in-dementia-a-proof-of-concept-study-100644705",false,"NCT07673770","Brain Wave Informed Non-invasive Brain Stimulation: Improving Neural Networks of Working Memory in Dementia: a Proof-of-concept Study","BWIBS-WM","Inclusion Criteria:\n\n* Individuals must be diagnosed with Alzheimer's Disease or related dementias by a clinician.\n* Individuals must exhibit adequate oral communication skills and cognitive function sufficient to obtain a score above 10 on the MMSE\n* Instructions will be delivered in English; therefore participants must demonstrate an understanding of instruction provided in English.\n* Individuals must be at least 55 years or older\n\nExclusion Criteria:\n\n* Contraindications to TMS; presence of a pacemaker, metal\u002Felectrical\u002Fmagnetic implants not including titanium, known history of untreated or uncontrolled psychological disorders, pregnancy, history of seizure or diagnoses of epilepsy, are taking any prescription medications that increase the risk of seizure.\n* Allergy to rubbing alcohol, which is needed to prepare electromyography for TMS","ALL","55 Years",{"count":56,"type":57},30,"ESTIMATED","INTERVENTIONAL",[60],"NA","Working memory helps us hold information for a short time so one can think and make decisions. It keeps thoughts on track. As one gets older, working memory gets weaker. In people with dementia, it gets much worse, making it harder to talk with others, follow directions, or remember things like shopping lists.\n\nThis may happen because brain waves that support working memory fall out of sync. Researchers can see these brain waves using a test called EEG. In this study, the investigators will try to get these brain waves back in sync using a safe, non-invasive form of brain stimulation called transcranial magnetic stimulation (TMS), and will time it to each person's brain waves to make it more effective. The goal is to improve working memory in people with dementia. If successful, dementia patients may be able to be more independent taking pressure off their families.",[63,64],"Dementia","Alzheimer s Disease",[63,66,67,68,69],"Alzheimer's Disease","transcranial magnetic stimulation","eeg","electroencephalography","2026-06-24",{"date":72,"type":73},"2026-06-29","ACTUAL",{"date":75,"type":57},"2026-06-01",{"date":77,"type":57},"2028-08-01",{"name":5,"class":6},1]