[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100053214":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":26,"centralContacts":33,"locations":39,"responsibleParty":56,"collaborators":20,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":20,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":20,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":42,"whyStopped":20,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"University of Southern California","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Acute Oral Nicotine Pouch Administration","EXPERIMENTAL","Adult cigarette smokers will complete one experimental session consisting of pre-pouch cue reactivity and subjective assessments, administration of a single 6 mg oral nicotine pouch, a standardized 25-minute absorption period, and identical post-pouch assessments. All participants complete the same study procedures and serve as their own control for pre- versus post-intervention comparisons.",[13,14],"Other: Oral Nicotine Pouch","Behavioral: Smoking Cue Reactivity Task",[16,21],{"type":6,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"Oral Nicotine Pouch","Participants will self-administer one commercially available 6 mg oral nicotine pouch following overnight nicotine abstinence. The pouch will be used for approximately 25 minutes before participants complete the post-pouch cue reactivity assessment.",[9],null,{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":20},"BEHAVIORAL","Smoking Cue Reactivity Task","Participants will complete a standardized smoking cue reactivity task before and after oral nicotine pouch administration. During each task, participants will view smoking-related and neutral images, complete guided imagination trials while holding either a cigarette or a neutral object, and undergo simultaneous functional near-infrared spectroscopy (fNIRS) to measure prefrontal brain activity.",[9],[27,30],{"name":28,"affiliation":5,"role":29},"Natalia Peraza","PRINCIPAL_INVESTIGATOR",{"name":31,"affiliation":5,"role":32},"John Monterosso","STUDY_CHAIR",[34],{"name":35,"role":36,"phone":37,"phoneExt":20,"email":38},"USC Nicotine and Tobacco Studies","CONTACT","213-821-0807","USCONPStudy@gmail.com",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"University of Southern California - 3641 Watt Way (HNB B22)","RECRUITING","Los Angeles","California","90089","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-118.24368,34.05223,{"lat":52,"lon":51},[55],{"name":35,"role":36,"phone":37,"phoneExt":20,"email":38},{"type":29,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"John Robert Monterosso","Associate Professor - Department of Psychology","100053214","braincraving-response-to-smoking-cues-after-oral-nicotine-pouch-use-100053214",false,"NCT07698470","Brain\u002FCraving Response to Smoking Cues After Oral Nicotine Pouch Use","Cue-Exposure Response Evaluation: Brain Reactivity to ONPs","Inclusion Criteria:\n\n* Age 21 years - 55 years\n* Self-reported use of cigarettes within the past 30 days\n* Biochemical confirmation of cigarette use:\n\n  o Carbon monoxide (CO) breath sample ≥10 ppm\n* Fagerström Test for Nicotine Dependence (FTND) score ≥5, indicating moderate to high nicotine dependence\n* Fluent in English\n* Willing to try an oral nicotine pouch\n* Willing to abstain from nicotine for at least 12 hours prior to each experimental session\n\nExclusion Criteria:\n\n* Age younger than 21 years or older than 55 years\n* Biochemical evidence inconsistent with recent cigarette use:\n\n  o CO breath sample \\\u003C10 ppm\n* Expressed intent to reduce or quit nicotine use within the next 30 days\n* History of medical conditions contraindicated for nicotine use (e.g., uncontrolled hypertension, recent cardiac events)\n* Primary use of non-cigarette products (e.g., cigars, pipe tobacco, smokeless tobacco)\n* Prior use of oral nicotine products in their lifetime",true,"ALL","21 Years","55 Years",{"count":71,"type":72},45,"ESTIMATED","INTERVENTIONAL",[75],"NA","Oral nicotine pouches (ONPs) are non-combustible nicotine products that may reduce cigarette craving and smoking cue-induced brain activity, supporting their potential as harm-reduction tools for adults who smoke cigarettes. This within-subject, repeated-measures study will evaluate the acute effects of a single 6 mg oral nicotine pouch on subjective craving and prefrontal neural responses to smoking-related cues using functional near-infrared spectroscopy (fNIRS). Participants will complete assessments before and after nicotine pouch administration following overnight nicotine abstinence to characterize changes in craving and neural cue reactivity.",[78],"Nicotine Dependence",[80,81,82,83,84],"Oral Nicotine Pouches","Oral Nicotine Products","Smoking","Cigarettes","Harm Reduction","2026-07-07",{"date":87,"type":88},"2026-07-13","ACTUAL",{"date":90,"type":88},"2026-04-30",{"date":92,"type":72},"2027-08",{"name":5,"class":6},1]