[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100504647":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":34,"responsibleParty":67,"collaborators":69,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":80,"minAge":10,"maxAge":10,"enrollmentInfo":81,"targetDuration":10,"studyType":84,"phases":10,"briefSummary":85,"conditions":86,"keywords":91,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"University Medical Center Groningen","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Breast cancer survivors",null,"Survivors of BC, diagnosed ≥11 years ago, who received chemotherapy and\u002For radiotherapy",[13],"Diagnostic Test: Echocardiography",{"label":15,"type":10,"description":16,"interventionNames":17},"Reference population","Age and GP matched reference population without a history of cancer",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","Echocardiography","During echocardiography, the following parameters will be assessed:\n\n* Dimensions\n* Left ventricle function\n* Right ventricle function\n* Valves: Aorta valve and pulmonic valve\n* Other findings such as: frequency, rhythm, quality",[9,15],[25,30],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Daan Brandenbarg, PhD","CONTACT","0031628475305","d.brandenbarg@umcg.nl",{"name":31,"role":27,"phone":32,"phoneExt":10,"email":33},"Laurine T van der Wal, MSc","0031503616154","l.t.van.der.wal@umcg.nl",[35],{"facility":5,"status":36,"city":37,"state":10,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"RECRUITING","Groningen","9700 AD","Netherlands","NL",{"type":42,"coordinates":43},"Point",[44,45],6.56667,53.21917,{"lat":45,"lon":44},[48,49,51,53,55,57,59,61,63,65],{"name":31,"role":27,"phone":32,"phoneExt":10,"email":33},{"name":26,"role":50,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"name":31,"role":52,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"name":54,"role":52,"phone":10,"phoneExt":10,"email":10},"Saskia WMC Maass, PhD",{"name":56,"role":50,"phone":10,"phoneExt":10,"email":10},"Jourik A Gietema, Prof. dr.",{"name":58,"role":50,"phone":10,"phoneExt":10,"email":10},"Peter van der Meer, Prof. dr.",{"name":60,"role":50,"phone":10,"phoneExt":10,"email":10},"Geertruida H de Bock, Prof. dr.",{"name":62,"role":50,"phone":10,"phoneExt":10,"email":10},"Marjolein Y Berger, Prof. dr.",{"name":64,"role":52,"phone":10,"phoneExt":10,"email":10},"Anne PG Crijns, PhD",{"name":66,"role":52,"phone":10,"phoneExt":10,"email":10},"Michiel R de Boer, PhD",{"type":68,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[70],{"name":71,"class":6},"ZonMw: The Netherlands Organisation for Health Research and Development","100504647","breast-cancer-long-term-outcomes-on-cardiac-functioning-a-longitudinal-study-100504647",false,"NCT05851053","Breast Cancer Long-term Outcomes on Cardiac Functioning: a Longitudinal Study","BLOC-II","Inclusion Criteria:\n\n* Patients who previously took part in de BLOC-I study will be included. These criteria were:\n* females diagnosed with stage I-III BC at least five years ago or local or locoregional recurrence of BC at least five years ago\n* treatment with chemotherapy and\u002For radiotherapy.\n\nExclusion Criteria:\n\n* Patients unfit to travel to the hospital due to severe mental or physical illness, based on assessment by their GP.\n\nExclusion criteria for the BC survivors in the BLOC-I study were:\n\n* metastatic disease at the time of BC diagnosis;\n* BC treatment after 80 years of age;\n* history of treatment for other types of cancer.",true,"FEMALE",{"count":82,"type":83},455,"ESTIMATED","OBSERVATIONAL","Rationale: In addition to surgery, effective breast cancer (BC) treatment typically requires chemotherapy, radiotherapy, or both. However, it is still unclear whether patients with BC are at increased risk of long-term cardiac dysfunction due to the adverse effects of these therapies. In a cross-sectional study in primary care, a comparison on cardiac dysfunction between 350 BC survivors and 350 age- and general practitioner (GP)- matched controls without cancer was made. In that study, BC survivors were at increased risk of mild systolic cardiac dysfunction (left ventricle ejection fraction (LVEF)\\\u003C 54%). By contrast, there was no significant difference in an LVEF \\\u003C 50% or in diastolic dysfunction. To date it remains uncertain whether the mild or subclinical dysfunction we observed predicts further cardiac deterioration. Consequently, the translation of these results into guidelines for the daily practice of the GP is unclear.\n\nObjective: The aim of the here proposed study is to clarify whether cardiac function in survivors of BC should be monitored by GPs, by assessing whether an unselected population of long-term BC survivors is at increased risk of developing cardiac dysfunction, whether in this group at-risk subgroups exists, and what factors are associated with the highest risk.\n\nStudy design: A new assessment of cardiac function among women included in the BLOC-I study. This produces a longitudinal matched cohort design consisting of two cohorts in primary care.\n\nStudy population: Survivors of BC, diagnosed ≥11 years ago who received chemotherapy and\u002For radiotherapy, and a matched reference population with no history of cancer. All participants participated in the Breast cancer Long-term Outcome of Cardiac function (BLOC-I) study.\n\nMain study parameters\u002Fendpoints: Left ventricular systolic dysfunction. Systolic cardiac dysfunction is defined as a LVEF \\\u003C54\u002F50\u002F45%.",[87,88,89,90],"Neoplasm, Breast","Heart Failure","Cardiotoxicity","Ventricular Dysfunction",[92,89,93],"Breast cancer","Heart failure","2024-05-28",{"date":96,"type":97},"2024-05-29","ACTUAL",{"date":99,"type":97},"2022-09-01",{"date":101,"type":83},"2026-12-31",{"name":5,"class":6},1]