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Treatment must have started on or after January 1, 2021.\n* Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2;\n* Consent to data treatment according to the local regulation.\n\nExclusion Criteria:\n\n* Current participation in any other HR+\u002FHER2- EBC study with any investigational products;\n* Patients who have already received adjuvant treatment with a CDK4\u002F6 inhibitor as part of a clinical trial;\n* Patients unable to comply with the requirements of the study or who, in the judge of the study physician, should not be included in the study;\n* Patients with a history of previous BC, with the exception of Ductal carcinoma in situ (DCIS) treated by locoregional therapy alone ≥5 years ago;\n* Patients with a history of any other cancer (except non-melanoma skin cancer or carcinoma in situ of the cervix), unless in complete remission with no therapy for a minimum of 5 years from the index date, will be excluded, as well.","ALL","18 Years",{"count":290,"type":291},750,"ESTIMATED","OBSERVATIONAL","This is a multicenter observational study with both retrospective and prospective phase, designed to evaluate the clinico-pathologic characteristics and outcomes of patients with HR+\u002FHER2- EBC at high risk of recurrence treated with ribociclib or abemaciclib in combination with ET in the adjuvant setting.",[295,296],"Adjuvant Therapy","CDK4\u002F6 Inhibitor","2026-05-28",{"date":299,"type":300},"2026-05-29","ACTUAL",{"date":302,"type":300},"2025-09-29",{"date":304,"type":291},"2030-08-01",{"name":5,"class":6},18]