[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100540363":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":18,"responsibleParty":35,"collaborators":7,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":43,"eligibilityCriteria":44,"healthyVolunteers":39,"sex":45,"minAge":46,"maxAge":47,"enrollmentInfo":48,"targetDuration":51,"studyType":52,"phases":7,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":21,"whyStopped":7,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},{"fullName":5,"class":6},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",null,[9,14],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Alba Di Leone, Doc","CONTACT","0039 3474980503","alba.dileone@policlinicogemelli.it",{"name":15,"role":11,"phone":16,"phoneExt":7,"email":17},"Chiara Naro, Doc","0039 3495087203","chiara.naro@unicatt.it",[19],{"facility":20,"status":21,"city":22,"state":7,"zip":23,"country":24,"countryCode":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":32},"IRCCS Fondazione Policlinico A. Gemelli","RECRUITING","Roma","00168","Italy","IT",{"type":27,"coordinates":28},"Point",[29,30],11.10642,44.99364,{"lat":30,"lon":29},[33],{"name":34,"role":11,"phone":12,"phoneExt":7,"email":13},"alba di leone, MD",{"type":36,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100540363","breast-cancer-subtype-characterization-through-patients-derived-organoids-100540363",false,"NCT06315868","Breast Cancer Subtype Characterization Through Patient's Derived Organoids.","Breast Cancer Subtype Characterization Through Patient's Derived Organoids\". (BCinsightPDO)","BCinsightPDO","Inclusion Criteria:\n\n* women diagnosed with primary BC, eligible for surgical resection of the tumor according to national and international guidelines.\n\nage between 18 and 70 years; newly diagnosed breast neoplasms, tumor size of at least 1.5 cm diameter.\n\nExclusion Criteria:\n\nbreast cancer diagnosed during pregnancy, neoadiuvant chemotherapy","ALL","18 Years","70 Years",{"count":49,"type":50},306,"ESTIMATED","5 Years","OBSERVATIONAL","Development of tools to predict patients chemo-sensitivity and identification of corresponding biomarkers is an urgent challenge for BC patients lacking targeted therapies, such as TNBC, or for patients experiencing relapse after adjuvant chemotherapy or targeted therapies.\n\nThe refinement of 3D-cultivation techniques, experienced in the last decade, has allowed cultivation of patients-derived cancer cells in organotypic structures, named patient-derived organoids (PDO), which preserve histologic, genomic and transcriptomic features of primary tumors. PDO allow propagation, pharmacological treatment and genetic manipulation of patients-derived cancer cells in a close to physiology setting, thus representing a promising tool in the development of personalized therapies",[55,56],"Breast Cancer","Organoids",[58,59,60],"breast cancer","new drugs","organoids","2024-03-11",{"date":63,"type":64},"2024-03-18","ACTUAL",{"date":66,"type":64},"2023-06-15",{"date":68,"type":50},"2027-06-15",{"name":5,"class":6},1]