[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631819":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":25,"responsibleParty":43,"collaborators":25,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":25,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":25,"overallStatus":68,"whyStopped":25,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":74,"leadSponsor":76,"locationsCount":25},{"fullName":5,"class":6},"German Institute of Human Nutrition","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Prolonged Exhalation Breathing","EXPERIMENTAL","Participants are required to perform a specific voluntarily controlled breathing pattern directed by visual cues. The core characteristic is a systematic lengthening of the expiratory phase relative to the inspiratory phase. Specifically, participants are instructed to inhale for 2 seconds and prolong their exhalation to 8 seconds",[13],"Behavioral: Instructed Prolonged Exhalation",{"label":15,"type":10,"description":16,"interventionNames":17},"Eupnea Breathing (Normal)","Eupnea (Normal breathing) condition: In this control condition, participants maintain their spontaneous respiratory rhythm. The pacing for eupnea is individualized for each participant, based on their natural breathing frequency sampled during representative non-interventional intervals of the session (e.g., baseline or post-stress recovery periods). This ensures the control condition reflects the participant's characteristic physiological state within the experimental context.",[18],"Behavioral: Instructed Individualized Eupnea",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Instructed Prolonged Exhalation","Participants are required to perform a specific instructed breathing pattern directed by visual cues. The core characteristic is a systematic lengthening of the expiratory phase relative to the inspiratory phase. Specifically, participants are instructed to inhale for 2 seconds and prolong their exhalation to 8 seconds.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Instructed Individualized Eupnea","Instructed Individualized Eupnea: In this control condition, participants are instructed to match their breath to a visual cue that is calibrated to their own characteristic natural respiratory frequency. This frequency is sampled during representative non-interventional phases of the session to capture the participant's individual baseline eupnea pace within the experimental context.",[15],[31],{"name":32,"affiliation":33,"role":34},"Soyoung Q Park, Prof. Dr.","German Institute of Human Nutrition Potsdam-Rehbruecke","PRINCIPAL_INVESTIGATOR",[36,40],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},"CONTACT","+49 033200 88 2510","soyoung.park@dife.de",{"name":41,"role":37,"phone":25,"phoneExt":25,"email":42},"Wenhao Huang","Wenhao.Huang@dife.de",{"type":34,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Prof. Dr. Soyoung Q Park","Prof. Dr.","100631819","breathing-and-decision-making-prolex-context-100631819",false,"NCT07505641","Breathing and Decision-Making (ProlEx-Context)","ProlEx-Context","Inclusion Criteria:\n\n* 18- to 40-year-old men and women\n* Consent to participate\n* Fluent in German\n* Right-handed\n* Physically and mentally healthy without regular medication\n* Body-mass index of 18-25 kg\u002Fm2\n* Alcohol consumption of less than 15 glasses a week (equivalent to one glass of wine\u002Fbeer, a glass of higher-percentage alcohol counts as two glasses of beer)\n* No illegal drug consumption in the week previous to the experiment\n* No smoking\n* No competitive athletes\n* Normal day-night rhythm (no shift work)\n* Normal vision without required vision correction (i.e., glasses, contact lenses; ability to clearly read texts at a distance of up to 50 cm without vision aids)\n\nExclusion Criteria:\n\n* Former or current illnesses of:\n* Brain or mind (including anxiety disorders, depression, eating disorders, personality disorders, alcohol, drugs or drug dependence, neurological disorders other than occasional headache, psychiatric or neurological abnormalities)\n* Heart or blood circulation\n* Lung Diseases\n* Other serious past or present medical conditions (for example, metabolic syndrome, diabetes)\n* Current medication and medication over a period of two weeks prior to the examination\n* Other serious health problems or present strong mental or physical stress\n* Current infection or excessive stress\n* Missing consent to receive information about incidental findings from the MRI\n* Tendency to claustrophobia, dizziness, or panic attacks\n* Wearing a non-removable pacemaker, defibrillator, hearing aid, drug pump, neurostimulator or implant with solenoid valve (e.g., artificial bowel outlet)\n* Metal parts or implants inside the body, for example, due to surgery or injury with a metallic foreign object (e.g., hip replacements, artificial joints, heart valves, vessel occlusions or dilatations, surgical clips, bone screws or plates, coil, shunts, catheters, electrodes, coils, radiation sources, shrapnel, projectiles, stents)\n* Having non-removable metal parts or metal-containing devices on or in the body\n* Having ferromagnetic metal parts or implants inside the body (e.g., hip replacements, artificial joints, heart valves, vessel occlusions or dilatations, surgical clips, bone screws or plates, coils, shunts, catheters, electrodes, coils, radiation sources, shrapnel, projectiles, stents)\n* Wearing magnetically fixed implants (e.g. amalgam fillings, glass eye)\n* Professionally or privately being involved in the processing of ferromagnetic metals\n* Large tattoos (whole limbs)\n* Pregnancy\n* Wearing an intra-uterine device\n* Having tinnitus\n* Extensive lung function (e.g. apnoe diver, singer, professional musician with lung-involving instruments)\n* Previous participation in the ProlEx-MRI study (the precursor to the current study)",true,"ALL","18 Years","40 Years",{"count":58,"type":59},50,"ESTIMATED","INTERVENTIONAL",[62],"NA","The ProlEx-Context study aims to investigate how a slow-paced breathing technique with prolonged exhalation affects decision-making in the context of acute social stress.",[65,66,67],"Breathing Techniques","Stress Management","Decision-Making","NOT_YET_RECRUITING","2026-03-26",{"date":71,"type":72},"2026-04-01","ACTUAL",{"date":71,"type":59},{"date":75,"type":59},"2027-04-01",{"name":5,"class":6}]