[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100372188":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":30,"responsibleParty":49,"collaborators":10,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":10,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":10,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Age matched Healthy participants (150)",null,"Healthy Participants Age: \\> 40y No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system",{"label":13,"type":10,"description":14,"interventionNames":10},"Coronary Artery Disease (CAD) Patients (200)","Coronary Artery Disease (CAD) Patients Age \\> 18 y Patients with an Indication for invasive coronary angiography based on symptoms and a test positive for inducible coronary ischemia, or previous coronary angiography.",[16],{"name":17,"affiliation":18,"role":19},"Matthias G Friedrich, MD","Reseach Institute of the McGill University health Center","PRINCIPAL_INVESTIGATOR",[21,27],{"name":22,"role":23,"phone":24,"phoneExt":25,"email":26},"Elizabeth Konidis","CONTACT","514 934-1934","37305","elisavet.konidis@muhc.mcgill.ca",{"name":28,"role":23,"phone":24,"phoneExt":25,"email":29},"Adonis Rodaros","adonis.rodaros@muhc.mcgill.ca",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"McGill University Health Center","RECRUITING","Montreal","Quebec","H4A 3J1","Canada","CA",{"type":40,"coordinates":41},"Point",[42,43],-73.58781,45.50884,{"lat":43,"lon":42},[46,48],{"name":17,"role":23,"phone":24,"phoneExt":10,"email":47},"mgfriedrich@gmail.com",{"name":22,"role":23,"phone":24,"phoneExt":25,"email":26},{"type":19,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Matthias Friedrich","Cardiologist","100372188","breathing-maneuver-induced-myocardial-oxygenation-reserve-validated-by-ffr-b-more-100372188",false,"NCT04126148","Breathing-Maneuver-Induced Myocardial Oxygenation Reserve Validated by FFR (B-MORE)","B-MORE","Inclusion Criteria:\n\nHealthy Participants\n\n* Age: \\> 40y\n* No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system.\n\nCAD Patients\n\n* Age \\> 18 y\n* Indication for invasive coronary angiography based on symptoms and a test positive for inducible coronary ischemia, or previous coronary angiography.\n\nExclusion Criteria:\n\nALL participants:\n\n* General MRI contraindications: Pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy.\n* Consumption of caffeine (coffee, tea, cocoa, chocolate, \"energy drink\") during the 12 hours prior to the exam.\n* Regular nicotine consumption during the last 6 months.\n\nPatients only\n\n* Vasoactive medication (e.g. nitro) during the 12 hours prior to the exam Contraindications to adenosine (2nd or 3rd A-V block, sinus node disease, asthma, bronchoconstrictive diseases).\n* Acute Coronary Syndrome (ACS), or previous Coronary Artery Bypass Surgery\n* Previous myocardial infarction within 1 month\n* Clinically unstable condition\n* Significant or uncontrolled arrhythmia",true,"ALL","18 Years",{"count":63,"type":64},350,"ESTIMATED","OBSERVATIONAL","The study aims to determine a diagnostic marker for regionally impaired myocardial oxygenation response in patients with suspected coronary artery stenosis.",[68],"Coronary Artery Stenosis","2024-10-22",{"date":71,"type":72},"2024-10-24","ACTUAL",{"date":74,"type":72},"2019-07-04",{"date":76,"type":64},"2024-12",{"name":5,"class":6},1]