[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100420117":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":33,"locations":42,"responsibleParty":61,"collaborators":24,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":24,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":24,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":45,"whyStopped":24,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"The University of Texas Health Science Center, Houston","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"BreEStim","EXPERIMENTAL","BreEStim is voluntary breathing controlled transcutaneous electrical nerve stimulation.",[13],"Device: BreEStim",{"label":15,"type":10,"description":16,"interventionNames":17},"EStim","EStim is transcutaneous electrical nerve stimulation.",[18],"Device: EStim",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"DEVICE","BreEStim will applied for 10 to 20 minutes.",[9],null,{"type":21,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"EStim will applied for 10 to 20 minutes.",[15],[29],{"name":30,"affiliation":31,"role":32},"Sheng Li, MD, PhD","University of Texas","PRINCIPAL_INVESTIGATOR",[34,38],{"name":30,"role":35,"phone":36,"phoneExt":24,"email":37},"CONTACT","(713) 797-7125","sheng.li@uth.tmc.edu",{"name":39,"role":35,"phone":40,"phoneExt":24,"email":41},"Shengai Li, MS","713-797-7561","shengai.li@uth.tmc.edu",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"The University of Texas Health Science Center","RECRUITING","Houston","Texas","77030","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-95.36327,29.76328,{"lat":55,"lon":54},[58,60],{"name":30,"role":35,"phone":59,"phoneExt":24,"email":37},"(713) 500-5874",{"name":39,"role":35,"phone":40,"phoneExt":24,"email":41},{"type":32,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Sheng Li","Professor","100420117","breestim-for-motor-recovery-in-chronic-stroke-with-severe-impairment-pilot-100420117",false,"NCT04750564","BreEStim for Motor Recovery in Chronic Stroke With Severe Impairment (Pilot)","BreEStim for Post-Stroke Motor Recovery","Inclusion criteria:\n\n* has post stroke ≥ 6 months , medically stable;\n* Unilateral, single stroke (no restriction on type (ischemic or hemorrhagic) or volume (large or small) of stroke);\n* MAS score ≥ 1, i.e., detectable finger flexor hypertonia;\n\nExclusion criteria include:\n\n* Patients with visual deficit\u002Fneglect; hearing or cognitive impairment;\n* Patients with history of pulmonary disease (Asthma, chronic obstruction pulmonary disease, COPD);\n* Patients that are currently adjusting tone alternating medications (e.g., baclofen), or\n* Patients received botulinum toxin injection to the arm\u002Ffingers \\\u003C4 months, or phenol injections \\\u003C 2 years;\n* Patients with a pacemaker;\n* Women who are pregnant.","ALL","18 Years","75 Years",{"count":75,"type":76},4,"ESTIMATED","INTERVENTIONAL",[79],"NA","The overall goal is to investigate the effectiveness of a novel intervention - Breathing-controlled electrical stimulation (BreEStim) on finger flexor spasticity reduction and hand function improvement in chronic stroke with severe impairment.",[82],"Motor Recovery",[84,82,9],"Finger flexor spasticity","2026-06-01",{"date":87,"type":88},"2026-06-03","ACTUAL",{"date":90,"type":88},"2025-09-01",{"date":92,"type":76},"2027-12-31",{"name":5,"class":6},1]