[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623149":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":34,"centralContacts":38,"locations":44,"responsibleParty":61,"collaborators":64,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":29,"eligibilityCriteria":76,"healthyVolunteers":73,"sex":77,"minAge":78,"maxAge":29,"enrollmentInfo":79,"targetDuration":29,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":46,"whyStopped":29,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"University of Michigan","OTHER",[8,15,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Virtual reality plus standard care (SC) then SC alone - randomized group","EXPERIMENTAL","Participants in this group are maintained on antidepressants or psychotherapy and will receive VR nature sessions alongside participants' current depression treatments. This will be followed by a 1-week washout period, after which they crossover to standard care only.",[13,14],"Device: Virtual Reality","Other: Standard care",{"label":16,"type":10,"description":17,"interventionNames":18},"Standard care alone then Virtual reality plus SC- randomized group","Participants in this group are maintained on standard depression treatments and will continue standard care for eight weeks. This will be followed by a 1-week washout period and crossover to VR plus Standard Care.",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"Virtual Reality - non-randomized group","Participants that are not receiving any treatment for depression will receive VR nature sessions for 8 weeks without depression treatments for eight weeks followed by 1 week washout and 8 weeks of no VR.",[13],[24,30],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"DEVICE","Virtual Reality","Participant will have 8 weeks of immersive VR nature-based experiences. Participants are expected to use the VR headset three times per week. Headsets will contain a prototype application (app) developed by Explore POV. This app will include approximately one hour of footage showcasing 15-25 different nature experiences, that will shuffle every time participants access it. Participants will have the option to choose between 5, 10, or 15 minutes, sessions while answering weekly surveys regarding their experiences.",[16,20,9],null,{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":29},"Standard care","Participants that are in the randomized groups will continue on antidepressants or psychotherapy during the study per their standard care. Participants in the non-randomized group don't receive any treatment for their depression and will continue not to receive anything for this during the study.",[16,9],[35],{"name":36,"affiliation":5,"role":37},"Hala Darwish, PhD","PRINCIPAL_INVESTIGATOR",[39],{"name":40,"role":41,"phone":42,"phoneExt":29,"email":43},"Zee Petrie","CONTACT","734- 764- 5249","petrieli@umich.edu",[45],{"facility":5,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"RECRUITING","Ann Arbor","Michigan","48109","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-83.74088,42.27756,{"lat":56,"lon":55},[59,60],{"name":40,"role":41,"phone":42,"phoneExt":29,"email":43},{"name":36,"role":37,"phone":29,"phoneExt":29,"email":29},{"type":37,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"Hala Darwish","Associate Professor of Nursing",[65,68],{"name":66,"class":67},"Apple Inc.","INDUSTRY",{"name":69,"class":70},"The International Organization of Multiple Sclerosis Nurses Inc","UNKNOWN","100623149","bringing-the-outdoors-in-virtual-nature-walks-for-depression-in-multiple-sclerosis-ms-patients-100623149",false,"NCT07392879","Bringing the Outdoors In: Virtual Nature Walks for Depression in Multiple Sclerosis (MS) Patients","Inclusion Criteria:\n\n* Confirmed diagnosis of progressive Multiple Sclerosis (MS, primary or secondary) by a neurologist or an MS center\n* Patient-Reported Outcomes Measurement Information System (PROMIS) Depression T-scores \\>55 at baseline\n* Ability to provide informed consent and participate in VR sessions at home\n* For Some Participants (Groups 1 and 2) currently receiving antidepressant or psychotherapy treatments (Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs), or psychotherapy) for the management of depression\n\nExclusion Criteria:\n\n* Severe cognitive impairments or visual deficits that may interfere with VR use, including contraindications like agoraphobia, claustrophobia, or motion sickness\n* Current participation in other clinical trials targeting depression\n* Severe psychiatric conditions that require hospitalization, or suicidal ideation, passive or active, psychosis, or active substance and alcohol abuse (score greater than 1 on CAGE (Cut down, Annoyed, Guilty, Eye-opener) Adapted to Include Drugs (CAGE-AID))\n* Another neurological or autoimmune disease per protocol\n* Participants that require vision correction, unless that vision correction is mild (± 1), or the participant has prescription contact lenses.","ALL","18 Years",{"count":80,"type":81},40,"ESTIMATED","INTERVENTIONAL",[84],"NA","This trial explores the use of immersive virtual reality (VR) nature-based experiences as a supplementary treatment for depression in individuals with progressive multiple sclerosis (MS). This study will evaluate the feasibility and efficacy of at-home VR deployment using the Apple Vision Pro, an advanced device that offers enhanced resolution, immersion, and usability compared to earlier VR systems.\n\nThe study hypotheses include:\n\n* The integration of VR nature-based experiences with standard care will be feasible, acceptable, and will result in greater reductions in depressive symptoms compared to standard care or VR-only interventions.\n* The integration of VR nature-based experiences with standard care will result in greater reductions in stress and anxiety, better sleep, less insomnia, and improved fatigue compared to standard care alone or VR-only interventions.",[87,88],"Progressive Multiple Sclerosis","Depression",[90],"Immersive virtual reality (VR)","2026-02-09",{"date":93,"type":94},"2026-02-12","ACTUAL",{"date":96,"type":94},"2025-12-15",{"date":98,"type":81},"2027-04",{"name":5,"class":6},1]