[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601801":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":31,"locations":37,"responsibleParty":51,"collaborators":18,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":18,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":18,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":39,"whyStopped":18,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"University of Kentucky","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Bromelain Supplement","EXPERIMENTAL","1000mg bromelain supplement once a day, 2 days prior to and 7 days following surgery",[13],"Dietary Supplement: Bromelain",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","NO_INTERVENTION","Standard of care",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Bromelain","1 tablet daily with water, for 9 days-starting 2 days before surgery and continuing for 7 days after. Record each dose in the provided log, along with any other medications taken and the time they were taken.",[9],[26],"Naturebell",[28],{"name":29,"affiliation":5,"role":30},"Mohamed Bazina, DDS, MSD","PRINCIPAL_INVESTIGATOR",[32],{"name":33,"role":34,"phone":35,"phoneExt":18,"email":36},"Emma E Palmer, DMD","CONTACT","859-358-6346","emma.palmer@uky.edu",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":18},"RECRUITING","Lexington","Kentucky","40356","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-84.47772,37.98869,{"lat":49,"lon":48},{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"SPONSOR_INVESTIGATOR","Mohamed Bazina","Assistant Professor","100601801","bromelain-for-post-surgery-facial-swelling-100601801",false,"NCT07115212","Bromelain for Post-surgery Facial Swelling","Effectiveness of Bromelain Supplement in Reduction of Facial Swelling Caused by Orthognathic Surgery","Inclusion Criteria:\n\n* undergoing orthognathic surgery\n\nExclusion Criteria:\n\n* craniofacial anomalies\n* incomplete patient data\n* systemic disease that could affect healing\n* allergy to latex or pineapple\n* under 18 years of age\n* non english speaking","ALL","18 Years","65 Years",{"count":66,"type":67},200,"ESTIMATED","INTERVENTIONAL",[70],"NA","The goal of this clinical trial is to learn if Bromelain Supplement works to decrease the amount of swelling or the amount of time swelling is present following jaw surgery. It will also learn about the safety of Bromelain supplement. The main questions it aims to answer are:\n\nDoes Bromelain decrease facial swelling following orthognathic, or jaw, surgery? Does Bromelain supplement decrease the amount of time that patients are swollen following orthognathic, or jaw, surgery?\n\nParticipants will:\n\nTake Bromelain supplement once daily for 9 days total. Take 2 days before surgery and 7 days following surgery.\n\nKeep a log of when the bromelain supplement is taken as well as another other medications.\n\nVisit the clinic with pre and post surgical protocol",[73],"Malocclusion",[22,75],"Oral Supplements","2026-06-03",{"date":78,"type":79},"2026-06-05","ACTUAL",{"date":81,"type":79},"2025-09-08",{"date":83,"type":67},"2028-05",{"name":53,"class":6},1]