[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614011":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":19,"locations":25,"responsibleParty":90,"collaborators":93,"id":102,"slug":103,"hasResults":104,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":104,"sex":110,"minAge":10,"maxAge":10,"enrollmentInfo":111,"targetDuration":10,"studyType":114,"phases":10,"briefSummary":115,"conditions":116,"keywords":118,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":135},{"fullName":5,"class":6},"Charles University, Czech Republic","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"TBE cohort",null,"Children and adults hospitalized with confirmed tick-borne encephalitis, followed prospectively for 12 months.",[13],"Other: No intervention",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"No intervention","Observational study only. Participants receive standard clinical care; no experimental or study-specific interventions are administered.",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Martin Slížek, MD","CONTACT","00420602269494","martin.slizek89@gmail.com",[26,46,62,74],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":10,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Ostrava University Hospital","RECRUITING","Ostrava","Moravian-Silesian Region","70800","Czechia",{"type":34,"coordinates":35},"Point",[36,37],18.28204,49.83465,{"lat":37,"lon":36},[40,44],{"name":41,"role":22,"phone":42,"phoneExt":10,"email":43},"Kateřina Pohludková, MD","00420 597 373 480","katerina.pohludkova@fno.cz",{"name":41,"role":45,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"facility":47,"status":28,"city":48,"state":49,"zip":50,"country":32,"countryCode":10,"cosmosGeoPoint":51,"geoPoint":55,"contacts":56},"Pardubická nemocnice","Pardubice","Pardubice Region","53001",{"type":34,"coordinates":52},[53,54],15.77659,50.04075,{"lat":54,"lon":53},[57,61],{"name":58,"role":22,"phone":59,"phoneExt":10,"email":60},"Lukáš Chovanec, MD","+420 466 014 613","lukas.chovanec@nempk.cz",{"name":58,"role":45,"phone":10,"phoneExt":10,"email":10},{"facility":63,"status":28,"city":64,"state":64,"zip":65,"country":32,"countryCode":10,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"Bulovka University Hospital","Prague","18081",{"type":34,"coordinates":67},[68,69],14.42076,50.08804,{"lat":69,"lon":68},[72,73],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},{"name":21,"role":45,"phone":10,"phoneExt":10,"email":10},{"facility":75,"status":28,"city":76,"state":77,"zip":78,"country":32,"countryCode":10,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"České Budějovice Hospital","České Budějovice","South Bohemian Region","37001",{"type":34,"coordinates":80},[81,82],14.47434,48.97447,{"lat":82,"lon":81},[85,89],{"name":86,"role":22,"phone":87,"phoneExt":10,"email":88},"Vojtěch Pražák, MD","00420387874601","infekcni@nemcb.cz",{"name":86,"role":45,"phone":10,"phoneExt":10,"email":10},{"type":45,"investigatorFullName":91,"investigatorTitle":92,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Martin Slížek","Principal Investigator, Department of Infectious Diseases",[94,95,97,100],{"name":75,"class":6},{"name":96,"class":6},"University Hospital Ostrava",{"name":98,"class":99},"Hospital Pardubice","UNKNOWN",{"name":101,"class":6},"Bulovka Hospital","100614011","burden-of-tick-borne-encephalitis-and-cost-effectiveness-of-vaccination-in-the-czech-republic-100614011",false,"NCT07274046","Burden of Tick-borne Encephalitis and Cost-effectiveness of Vaccination in the Czech Republic","Clinical and Public-Health Impact of Tick-Borne Encephalitis: A Prospective Multicenter Observational Study With 12-Month Follow-up and Cost-Effectiveness Analysis","ENCZECH","Inclusion Criteria:\n\n* Hospitalization due to suspected central nervous system (CNS) infection.\n* Laboratory-confirmed TBE, defined as:\n\nthe presence of CNS symptoms and cerebrospinal fluid pleocytosis (\\>5 × 10⁶\u002FL) and TBEV IgM and IgG seropositivity in serum, or detection of TBEV IgM in CSF in previously vaccinated individuals.\n\n* All age groups (children and adults).\n* Ability to participate in scheduled follow-up (in person or via telephone).\n* Informed consent provided by the patient or legal guardian (for minors).\n\nExclusion Criteria:\n\n* Alternative diagnosis explaining the CNS symptoms\n* Missing essential clinical or laboratory data required to confirm TBE or assess outcomes.\n* Refusal or inability to provide informed consent.\n* Inability to complete follow-up assessments, including situations where reliable contact cannot be maintained.\n* Coexisting severe neurological disorder unrelated to TBE that prevents meaningful evaluation of sequelae (e.g., advanced neurodegenerative disease, severe preexisting motor disability).","ALL",{"count":112,"type":113},209,"ESTIMATED","OBSERVATIONAL","This observational study follows children and adults who were hospitalized with tick-borne encephalitis (TBE) in the Czech Republic. The aim is to better understand how individuals recover from TBE, which symptoms may persist after the infection, and which patients may require additional support during their recovery. Participants are examined several times after hospital discharge (at 2-4 weeks, 3 months, 6 months, and 12 months) to observe changes in symptoms, functional status, and daily activities. Follow-up assessments include evaluation of common post-infection problems such as tiredness, headaches, memory or concentration difficulties, sleep issues, or limb weakness. Symptoms lasting for several months are categorized as post-encephalitic syndrome (PES).\n\nThe study also assesses how TBE affects daily functioning, school and work performance, and overall quality of life using questionnaires and short functional assessments. In addition, the study includes a public-health component that estimates the broader impact of TBE in the population and evaluates the potential benefits of vaccination in preventing long-term health complications.\n\nThe findings aim to support improved patient care, follow-up planning, and evidence-based public-health decision-making in the Czech Republic.",[117],"Tick Borne Encephalitis (TBE)",[119,120,121,122,123,124,125],"tick-borne encephalitis","sequelae","post-encephalitic syndrome","age","TBEV","encephalitis","cost-effectiveness","2025-12-09",{"date":128,"type":129},"2025-12-10","ACTUAL",{"date":131,"type":129},"2023-04-01",{"date":133,"type":113},"2026-12",{"name":5,"class":6},4]