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Istituto Tumori Giovanni Paolo II - U.O.C. Ematologia","PRINCIPAL_INVESTIGATOR",[18,23],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},"Uffici Studi FIL","CONTACT","+390131033153","startup@filinf.it",{"name":19,"role":20,"phone":24,"phoneExt":10,"email":25},"+390599769913","gestionestudi@filinf.it",[27,43,56,68,81,94,107,120,133,143,153,166,179,192,205,218,228,241,254],{"facility":28,"status":10,"city":29,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"A.O.R.N. S. Giuseppe Moscati - S.C. 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Ovest Milanese Ospedale di Legnano - U.O.C. di Ematologia","Legnano",{"type":33,"coordinates":111},[112,113],8.91506,45.59788,{"lat":113,"lon":112},[116,119],{"name":117,"role":20,"phone":10,"phoneExt":10,"email":118},"Silvia Franceschetti, MD","silvia.franceschetti@asst-ovestmi.it",{"name":117,"role":16,"phone":10,"phoneExt":10,"email":10},{"facility":121,"status":10,"city":122,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":123,"geoPoint":127,"contacts":128},"A.S.S.T. Grande Ospedale Metropolitano Niguarda - S.C. Ematologia","Milan",{"type":33,"coordinates":124},[125,126],12.59836,42.78235,{"lat":126,"lon":125},[129,132],{"name":130,"role":20,"phone":10,"phoneExt":10,"email":131},"Erika Meli, MD","erika.meli@ospedaleniguarda.it",{"name":130,"role":16,"phone":10,"phoneExt":10,"email":10},{"facility":134,"status":10,"city":122,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":135,"geoPoint":137,"contacts":138},"I.R.C.C.S. Istituto Europeo di Oncologia - U.O. Oncoematologia",{"type":33,"coordinates":136},[125,126],{"lat":126,"lon":125},[139,142],{"name":140,"role":20,"phone":10,"phoneExt":10,"email":141},"Caterina Cristinelli, MD","caterina.cristinelli@ieo.it",{"name":140,"role":16,"phone":10,"phoneExt":10,"email":10},{"facility":144,"status":10,"city":122,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":145,"geoPoint":147,"contacts":148},"I.R.C.C.S. Ospedale San Raffaele - U.O. Ematologia e Trapianto di Midollo Osseo",{"type":33,"coordinates":146},[125,126],{"lat":126,"lon":125},[149,152],{"name":150,"role":20,"phone":10,"phoneExt":10,"email":151},"Federico Erbella, MD","erbella.federico@hsr.it",{"name":150,"role":16,"phone":10,"phoneExt":10,"email":10},{"facility":154,"status":10,"city":155,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":156,"geoPoint":160,"contacts":161},"A.S.L. di Pescara P.O. Santo Spirito - U.O.C. Ematologia","Pescara",{"type":33,"coordinates":157},[158,159],14.20283,42.4584,{"lat":159,"lon":158},[162,165],{"name":163,"role":20,"phone":10,"phoneExt":10,"email":164},"Giuseppina Ricciuti, MD","giuseppina.ricciuti@asl.pe.it",{"name":163,"role":16,"phone":10,"phoneExt":10,"email":10},{"facility":167,"status":10,"city":168,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":169,"geoPoint":173,"contacts":174},"A.U.S.L. di Piacenza Osp. Guglielmo da Saliceto - U.O.C. Ematologia e Centro Trapianti","Piacenza",{"type":33,"coordinates":170},[171,172],9.69342,45.05242,{"lat":172,"lon":171},[175,178],{"name":176,"role":20,"phone":10,"phoneExt":10,"email":177},"Annalisa Arcari, MD","a.arcari@ausl.pc.it",{"name":176,"role":16,"phone":10,"phoneExt":10,"email":10},{"facility":180,"status":10,"city":181,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":182,"geoPoint":186,"contacts":187},"I.R.C.C.S. Fondazione Policlinico Universitario Gemelli - U.O.S.D. Malattie linfoproliferative extramidollari","Roma",{"type":33,"coordinates":183},[184,185],11.10642,44.99364,{"lat":185,"lon":184},[188,191],{"name":189,"role":20,"phone":10,"phoneExt":10,"email":190},"Francesco D'Alò, MD","francesco.dalo@unicatt.it",{"name":189,"role":16,"phone":10,"phoneExt":10,"email":10},{"facility":193,"status":10,"city":194,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":195,"geoPoint":199,"contacts":200},"IRCCS Humanitas Research Hospital - U.O. Ematologia","Rozzano",{"type":33,"coordinates":196},[197,198],9.1559,45.38193,{"lat":198,"lon":197},[201,204],{"name":202,"role":20,"phone":10,"phoneExt":10,"email":203},"Filippo Bagnoli, MD","filippo.bagnoli@cancercenter.humanitas.it",{"name":202,"role":16,"phone":10,"phoneExt":10,"email":10},{"facility":206,"status":10,"city":207,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":208,"geoPoint":212,"contacts":213},"A.O. Ordine Mauriziano - S.C.D.U. Ematologia","Torino",{"type":33,"coordinates":209},[210,211],11.99138,44.88856,{"lat":211,"lon":210},[214,217],{"name":215,"role":20,"phone":10,"phoneExt":10,"email":216},"Daniela Gottardi, MD","dgottardi@mauriziano.it",{"name":215,"role":16,"phone":10,"phoneExt":10,"email":10},{"facility":219,"status":10,"city":207,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":220,"geoPoint":222,"contacts":223},"A.O.U. Città della Salute e della Scienza di Torino - S.C. Ematologia",{"type":33,"coordinates":221},[210,211],{"lat":211,"lon":210},[224,227],{"name":225,"role":20,"phone":10,"phoneExt":10,"email":226},"Barbara Botto, MD","bbotto@cittadellasalute.to.it",{"name":225,"role":16,"phone":10,"phoneExt":10,"email":10},{"facility":229,"status":10,"city":230,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":231,"geoPoint":235,"contacts":236},"U.L.S.S. 2 Marca Trevigiana Osp. Ca' Foncello - U.O.C. Ematologia","Treviso",{"type":33,"coordinates":232},[233,234],12.2416,45.66673,{"lat":234,"lon":233},[237,240],{"name":238,"role":20,"phone":10,"phoneExt":10,"email":239},"Elisabetta Scarpa, MD","elisabetta.scarpa@aulss2.veneto.it",{"name":238,"role":16,"phone":10,"phoneExt":10,"email":10},{"facility":242,"status":10,"city":243,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":244,"geoPoint":248,"contacts":249},"A.S.S.T. Sette Laghi - S.C. Ematologia","Varese",{"type":33,"coordinates":245},[246,247],8.82511,45.82058,{"lat":247,"lon":246},[250,253],{"name":251,"role":20,"phone":10,"phoneExt":10,"email":252},"Marta Coscia, MD","Marta.Coscia@asst-settelaghi.it",{"name":251,"role":16,"phone":10,"phoneExt":10,"email":10},{"facility":255,"status":10,"city":256,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":257,"geoPoint":261,"contacts":262},"U.L.S.S. 8 Berica - U.O.C. Ematologia","Vicenza",{"type":33,"coordinates":258},[259,260],11.5475,45.54672,{"lat":260,"lon":259},[263,266],{"name":264,"role":20,"phone":10,"phoneExt":10,"email":265},"Marcello Riva, MD","marcello.riva@aulss8.veneto.it",{"name":264,"role":16,"phone":10,"phoneExt":10,"email":10},{"type":268,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100628874","bv-chp-real-life-and-biological-evidences-in-patients-with-salcl-100628874",false,"NCT07467317","BV-CHP Real-life and Biological Evidences in Patients With sALCL","FIL_BREAL: BV-CHP Real-life and Biological Evidences in Patients With sALCL","FIL_BREAL","Inclusion Criteria:\n\n* Age ≥18 years;\n* Histological diagnosis of sALCL (ALK positive and ALK negative);\n* Have received BV-CHP as front-line therapy in real life setting;\n* Availability of histological material of initial ALCLs diagnosis: a FFPE block from an excisional\u002Fincisional biopsy must be provided for patient enrollment. FNAB and GNAB will not be considered for the study;\n* Signed written informed consent\n\nExclusion Criteria:\n\n* Histological diagnosis other than sALCL;\n* Front line treatment other than BV-CHP;\n* Patients treated with BV-CHP in the contest of a clinical trial;\n* Refuse to sign a written informed consent.","ALL","18 Years",{"count":280,"type":281},100,"ESTIMATED","OBSERVATIONAL","Systemic Anaplastic Large Cell Lymphomas (sALCL) are rare lymphomas for which the cooperation in the collection of biological and clinical data is necessary to improve knowledge on the disease. The addition of a targeted therapy to chemotherapy recently showed to be effective compared to standard chemotherapy. First-line therapy brentuximab vedotin-CHP for sALCL was recently approved in Italy following the published 5-year data from the ECHELON-2 study. Correlations with biological parameters are missing.\n\nWithin the framework of the FIL, Investigators will assess the clinical outcomes-specifically response rates, progression-free survival (PFS), safety-in a retrospective cohort of patients diagnosed with sALCL and treated frontline with BV-CHP in the real-life setting. These outcomes will be correlated with data derived from PET\u002FCT imaging and lymph node biological samples.\n\nFurthermore, Investigators will collect lymph node samples of patients diagnosed with sALCL and treated with BV-CHP at FIL Centers. The study will investigate the prognostic relevance of known molecular alterations (e.g., DUSP22, TP63). Through whole-exome sequencing and transcriptomic profiling, recurrent genetic alterations will be explored, as well as the cell of origin and the tumor microenvironment of sALCL, with particular attention to cell-to-cell interactions. A machine learning model will be validated to identify DUSP22 rearrangements from hematoxylin\\&eosin (H\\&E)-stained slides. Finally, integrated analysis of omics and clinical data using AI will aim to uncover biological signatures predictive of treatment response.",[285],"Anaplastic Large Cell Lymphoma",[285,287,288,289,290,291,292],"ALK","DUSP22","TP63","BV-CHP","Brentuximab vedotin","sALCL","NOT_YET_RECRUITING","2026-03-27",{"date":296,"type":297},"2026-03-30","ACTUAL",{"date":299,"type":281},"2026-05",{"date":301,"type":281},"2028-05",{"name":5,"class":6},19]