[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642042":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":51,"collaborators":26,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":26,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":26,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":77,"whyStopped":26,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Caffeine","ACTIVE_COMPARATOR","30 minutes before spinal anesthesia in the preoperative area, the patient will receive 200 mg caffeine capsule",[13],"Drug: Caffeine (200 mg)",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","PLACEBO_COMPARATOR","30 minutes before spinal anesthesia in the preoperative area, the patient will receive placebo",[19],"Drug: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Caffeine (200 mg)","Patients will receive 200 mg oral caffeine 30 minutes before spinal anesthesia",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","Patient will receive placebo capsule",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Mina Adolf Helmy, MD","CONTACT","01275716942","minaadolf1988@cu.edu.eg",[38],{"facility":39,"status":26,"city":40,"state":26,"zip":26,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Cairo University Hospitals","Cairo","Egypt","EG",{"type":44,"coordinates":45},"Point",[46,47],31.24967,30.06263,{"lat":47,"lon":46},[50],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Mina Adolf Helmy","Doctor","100642042","caffeine-and-prophylactic-noradrenaline-requirement-during-cesarean-delivery-100642042",false,"NCT07655245","Caffeine and Prophylactic Noradrenaline Requirement During Cesarean Delivery","Effect of Preoperative Oral Caffeine on Prophylactic Noradrenaline Requirement During Cesarean Delivery: A Double-blind Placebo-controlled Trial","Inclusion Criteria:\n\n* Full-term singleton pregnant (\\>37 weeks)\n* ASA II\n* undergoing elective cesarean section.\n\nExclusion Criteria:\n\n* Patient refusal\n* SBP \\\u003C 100 mmHg\n* Allergy to local anesthetics or caffeine\n* Coagulopathy (INR\\>1.4 or platelets \\\u003C75.000)\n* Preeclampsia","FEMALE","20 Years","40 Years",{"count":66,"type":67},62,"ESTIMATED","INTERVENTIONAL",[70],"NA","Spinal anesthesia is the preferred regional technique in obstetric practice because it provides high maternal satisfaction and eliminates the need for airway manipulation. Despite these advantages, it is frequently complicated by spinal anesthesia-induced hypotension , defined as a reduction in systolic blood pressure of more than 20% from baseline or an absolute SBP below 100 mmHg. Spinal hypotension can have serious consequences, including maternal hypoperfusion that may lead to neurological or renal dysfunction, as well as fetal acidosis and bradycardia, which can compromise neonatal outcomes. The present study aims to evaluate the effect of preoperative caffeine administration on noradrenaline requirements during spinal anesthesia in obstetric patients. Specifically, the objectives are to compare noradrenaline requirements between the study groups and to assess the incidence of hypotension in both groups.",[73,74],"Spinal Hypotension","Vasopressor",[76,74,9],"Spinal anesthesia induced hypotension","NOT_YET_RECRUITING","2026-06-12",{"date":80,"type":81},"2026-06-17","ACTUAL",{"date":83,"type":67},"2026-06-16",{"date":85,"type":67},"2026-09-19",{"name":5,"class":6},1]