[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639834":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":39,"responsibleParty":71,"collaborators":74,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":25,"eligibilityCriteria":82,"healthyVolunteers":78,"sex":83,"minAge":84,"maxAge":25,"enrollmentInfo":85,"targetDuration":25,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Tartu University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Lower dose calcium replacement","ACTIVE_COMPARATOR","calcium carbonate 1250 mg x 2",[13],"Drug: Calcium carbonate 1250 mg (500 mg elemental calcium) twice a day",{"label":15,"type":10,"description":16,"interventionNames":17},"Higher dose calcium replacement","calcium carbonate 1250 mg x 4",[18],"Drug: Calcium carbonate 1250 mg (500 mg elemental calcium) 4 times a day",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Calcium carbonate 1250 mg (500 mg elemental calcium) twice a day","One study group takes calcium carbonate 1250 mg (500 mg elemental calcium) twice a day (at lunchtime and in the evening)",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Calcium carbonate 1250 mg (500 mg elemental calcium) 4 times a day","The second study group takes 1250 mg of calcium carbonate (500 mg of elemental calcium) four times a day (starting at noon, at approximately 4-hour intervals: at noon, in the early afternoon, in the evening, and before bedtime). This dosage regimen is prescribed because 500 mg of calcium can be absorbed at a time.",[15],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Hanna Hollman","CONTACT","+37259037517","hanna.hollman@ut.ee",{"name":37,"role":33,"phone":38,"phoneExt":25,"email":25},"Ceith Nikkolo","+372 53318092",[40,59],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"East Tallinn Central Hospital","RECRUITING","Tallinn","Other","11914","Estonia","EE",{"type":49,"coordinates":50},"Point",[51,52],24.75353,59.43696,{"lat":52,"lon":51},[55],{"name":56,"role":33,"phone":57,"phoneExt":25,"email":58},"Hanna Hollman, MD","+ 372 59037517","hanna.hollman@itk.ee",{"facility":5,"status":42,"city":60,"state":25,"zip":25,"country":46,"countryCode":47,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"Tartu",{"type":49,"coordinates":62},[63,64],26.72509,58.38062,{"lat":64,"lon":63},[67],{"name":68,"role":33,"phone":69,"phoneExt":25,"email":70},"Ceith Nikkolo, PhD","+372 53319082","ceith.nikkolo@kliinikum.ee",{"type":72,"investigatorFullName":37,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","general surgeon, PhD",[75],{"name":41,"class":6},"100639834","calcium-replacement-therapy-in-postoperative-hypoparathyroidism-100639834",false,"NCT07577570","Calcium Replacement Therapy in Postoperative Hypoparathyroidism","A Pilot Study of Calcium Replacement Therapy in Postoperative Hypoparathyroidism","Inclusion Criteria:\n\n* patients over the age of 18 undergoing surgery involving both lobes of the thyroid gland (thyroidectomy, \"near-total\" thyroidectomy, subtotal thyroidectomy, and \"completed\" thyroidectomy)\n* Based on the first post-operative day analysis, PTH levels are below the normal range (in our hospitals 1.8-7.8 pmol\u002Fl), but not so low (below 1.06 pmol\u002FL) as to require calcium replacement therapy with calcitriol (rocaltrol)\n\nExclusion Criteria:\n\n* previously diagnosed osteoporosis; the patient is already taking calcium and vitamin D supplements prior to thyroid surgery\n* renal insufficiency (eGFR \\\u003C 30)\n* patients with concomitant hyperparathyroidism undergoing simultaneous thyroidectomy and parathyroidectomy for a parathyroid adenoma","ALL","18 Years",{"count":86,"type":87},50,"ESTIMATED","INTERVENTIONAL",[90],"NA","The goal of this clinical trial is to evaluate whether a lower-dose calcium replacement therapy is non-inferior to a higher-dose regimen in preventing symptomatic hypoparathyroidism in patients following thyroidectomy. The hypothesis is:\n\n• lower-dose calcium replacement therapy is non-inferior to higher-dose therapy in preventing symptomatic hypoparathyroidism during the first two postoperative weeks\n\nResearchers will compare patients receiving a lower-dose calcium replacement regimen with those receiving a higher-dose regimen to assess whether the lower dose is not associated with a higher incidence of symptomatic hypoparathyroidism.\n\nPatients who develop post-thyroidectomy hypoparathyroidism are divided into groups for calcium replacement therapy. If they are asymptomatic, they will be scheduled for a follow-up visit at two weeks after surgery. During the follow-up visit, calcium metabolism will be evaluated, and treatment adjusted if necessary.",[93],"Post-Thyroidectomy Hypoparathyroidism Treatment",[95,96,97],"thyroidectomy","calcium replacement therapy","postoperative hypoparathyroidism","2026-05-05",{"date":100,"type":101},"2026-05-11","ACTUAL",{"date":103,"type":101},"2025-11-18",{"date":105,"type":87},"2028-12",{"name":5,"class":6},2]