[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100540508":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":40,"centralContacts":45,"locations":31,"responsibleParty":53,"collaborators":31,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":31,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":81,"whyStopped":31,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":31},{"fullName":5,"class":6},"University of Minho","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental condition 1","EXPERIMENTAL","Participants allocated to the Experimental condition 1 will be following a aerobic exercise training program.",[13],"Behavioral: Aerobic Exercise",{"label":15,"type":10,"description":16,"interventionNames":17},"Experimental condition 2","Participants allocated to the Experimental condition 2 will be following an agility-cognitive exercise training program.",[18],"Behavioral: Agility-Cognitive Exercise",{"label":20,"type":21,"description":22,"interventionNames":23},"Control condition","ACTIVE_COMPARATOR","Participants allocated to the Control condition will be following a stretching\u002Frelaxation training program.",[24],"Behavioral: Stretching\u002Frelaxation",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"BEHAVIORAL","Aerobic Exercise","Participants allocated to the Aerobic condition will be following a 4 month-intervention aerobic exercise protocol of 3 weekly interleaved sessions with a 50 minutes duration",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Agility-Cognitive Exercise","Participants allocated to the Agility-Cognitive condition will be following a 4 month-intervention agility-cognitive exercise protocol of 3 weekly interleaved sessions with a 50 minutes duration",[15],{"type":27,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"Stretching\u002Frelaxation","Participants allocated to the stretching control condition will be following a 4 month-intervention protocol of 1 weekly session with a 50 minutes duration",[20],[41],{"name":42,"affiliation":43,"role":44},"Sónia Sousa, PhD","Research Center in Psychology, School of Psychology, University of Minho","PRINCIPAL_INVESTIGATOR",[46,50],{"name":42,"role":47,"phone":48,"phoneExt":31,"email":49},"CONTACT","+351917824280","soniamachado@psi.uminho.pt",{"name":51,"role":47,"phone":31,"phoneExt":31,"email":52},"Adriana Sampaio, PhD","adriana.sampaio@psi.uminho.pt",{"type":44,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"Sonia Sousa","Principal Investigator","100540508","can-exercise-rewire-the-brain-addiction-circuitry-100540508",false,"NCT06317753","Can Exercise Rewire the Brain Addiction Circuitry?","Can Exercise Rewire the Brain Addiction Circuitry? A Randomized Trial of Exercise and Binge Drinking","REWIRED","Inclusion Criteria:\n\n* binge drinking \\> or = 5 ; \\> or =4 for women alcoholic drinks\n* in the same time window (±2h)\n* at least once per month\n* \\\u003C150 minutes of physical activity per week\n\nExclusion Criteria:\n\n* Major and\u002For unstable medical conditions\n* Physical limitations that may constraint the practice of exercise\n* Cardiovascular and respiratory insufficiency\n* History of traumatic brain injury or neurological disorder\n* Non-corrected sensory deficits\n* Personal history of psychopathological disorders\n* Family history of alcoholism or substance abuse in first degree relatives\n* Consumption of medical drugs with psychoactive effects (e.g., sedatives or anxiolytics) during the month previous to the assessment\n* Use of illegal drugs and AUDIT scores \\>20\n* MRI contraindications\n* Current or previous (past year) participation in a physical exercise program",true,"ALL","18 Years","24 Years",{"count":69,"type":70},60,"ESTIMATED","INTERVENTIONAL",[73],"NA","The aim of the present study is to apply neuroimaging techniques to investigate how physical exercise may influence the addiction circuitry, ultimately reducing alcohol consumption and craving in youth binge drinkers. This proposal will advance knowledge on how exercise may modulate the neurocircuitry of addiction. Uncovering the neurobiological mechanisms underlying the interactive neural effects of exercise and alcohol intake may provide additional scientific insights for the development of preventive and intervention programs for youth BD and AUD.",[76],"Physical Exercise",[78,79,80],"Addiction circuitry","Binge drinking","Neuroimaging","NOT_YET_RECRUITING","2025-03-31",{"date":84,"type":85},"2025-04-03","ACTUAL",{"date":87,"type":70},"2026-01",{"date":89,"type":70},"2027-12",{"name":5,"class":6}]