[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100582087":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":10,"centralContacts":10,"locations":27,"responsibleParty":122,"collaborators":10,"id":124,"slug":125,"hasResults":126,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":132,"sex":133,"minAge":134,"maxAge":10,"enrollmentInfo":135,"targetDuration":10,"studyType":138,"phases":10,"briefSummary":139,"conditions":140,"keywords":142,"overallStatus":50,"whyStopped":10,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":154},{"fullName":5,"class":6},"McMaster University","OTHER",[8,13,16,19],{"label":9,"type":10,"description":10,"interventionNames":11},"Asthma",null,[12],"Other: Observational",{"label":14,"type":10,"description":10,"interventionNames":15},"Chronic Obstructive Pulmonary Disease (COPD)",[12],{"label":17,"type":10,"description":10,"interventionNames":18},"Chronic cough",[12],{"label":20,"type":10,"description":10,"interventionNames":21},"Control group",[12],[23],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"Observational","This is a 24-month observational study in adults in three disease domains, consisting of screening visit, baseline visit, quarterly telemonitoring visit and end of monitoring period",[9,14,17,20],[28,48,65,80,94,108],{"facility":29,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"St. Paul's Hospital","NOT_YET_RECRUITING","Vancouver","British Columbia","V6Z 1Y6","Canada","CA",{"type":37,"coordinates":38},"Point",[39,40],-123.11934,49.24966,{"lat":40,"lon":39},[43],{"name":44,"role":45,"phone":46,"phoneExt":10,"email":47},"Don Sin","CONTACT","604-806-9033","Don.Sin@hli.ubc.ca",{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":34,"countryCode":35,"cosmosGeoPoint":54,"geoPoint":58,"contacts":59},"St. Joseph's Healthcare Hamilton","RECRUITING","Hamilton","Ontario","L8N 4A6",{"type":37,"coordinates":55},[56,57],-79.84963,43.25011,{"lat":57,"lon":56},[60],{"name":61,"role":45,"phone":62,"phoneExt":63,"email":64},"Manali Mukherjee","905-522-1155","35594","mukherj@mcmaster.ca",{"facility":66,"status":30,"city":67,"state":52,"zip":68,"country":34,"countryCode":35,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"Robarts Research Institute","London","N6A 5B7",{"type":37,"coordinates":70},[71,72],-81.23304,42.98339,{"lat":72,"lon":71},[75],{"name":76,"role":45,"phone":77,"phoneExt":78,"email":79},"Grace Parraga","519-931-5777","24197","gparraga@uwo.ca",{"facility":81,"status":30,"city":82,"state":52,"zip":83,"country":34,"countryCode":35,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"The Ottawa Hospital","Ottawa","K1H 8L6",{"type":37,"coordinates":85},[86,87],-75.69812,45.41117,{"lat":87,"lon":86},[90],{"name":91,"role":45,"phone":92,"phoneExt":10,"email":93},"Shawn Aaron","(613) 737-8259","SAARON@toh.ca",{"facility":95,"status":30,"city":96,"state":97,"zip":98,"country":34,"countryCode":35,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"Quebec Heart and Lung Institute - Laval University","Québec","Quebec","G1V 4G5",{"type":37,"coordinates":100},[101,102],-71.21454,46.81228,{"lat":102,"lon":101},[105],{"name":106,"role":45,"phone":10,"phoneExt":10,"email":107},"Andréanne Cote","andreanne.cote@criucpq.ulaval.ca",{"facility":109,"status":30,"city":110,"state":97,"zip":111,"country":34,"countryCode":35,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"Université de Sherbrooke","Sherbrooke","J1H 5N4",{"type":37,"coordinates":113},[114,115],-71.89908,45.40008,{"lat":115,"lon":114},[118],{"name":119,"role":45,"phone":120,"phoneExt":10,"email":121},"Simon Couillard","819-821-8000","Simon.Couillard2@USherbrooke.ca",{"type":123,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100582087","canadian-consortium-on-airway-mucus-occlusions-in-asthma-copd-and-chronic-cough-100582087",false,"NCT06858748","Canadian Consortium on Airway Mucus Occlusions in Asthma, COPD and Chronic Cough","Canadian Consortium for Understanding the Role of Airway Mucus Occlusions in Asthma, COPD and Chronic Cough","CANMuc","Inclusion Criteria:\n\n* Males and females (≥18 years old)\n\nAsthma: Respiratory physician confirmed diagnosis of moderate-to-severe asthma and Historical objective evidence of asthma and\u002For specialist\u002Frespirologist confirmation (post-bronchodilator reversibility and\u002For methacholine bronchoprovocation test \\\u003C8 mg\u002FmL)\n\nCOPD: Respiratory physician confirmed diagnosis of COPD that is moderate-to-severe according to GOLD criteria (post-bronchodilator FEV1\u002FFVC\\\u003CLLN and FEV1\\\u003C 80%pred) and CAT score ≥10 or mMRC score ≥ 2\n\nChronic cough: Refractory Chronic Cough (RCC) and Unexplained Chronic Cough (UCC) lasting \\>1 year with Normal chest radiograph and no airflow obstruction (FEV1\u002FFVC \\>Lower Limit of Normal)\n\nHealthy participants: No history of respiratory disease or other pulmonary disorders and no use of inhaled medications or corticosteroids with normal spirometry and Modified Medical Research Council (mMRC) Dyspnea Scale =\\\u003C1\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding\n* Current smoker or \\>10 yr pack history or smoked within the last 6 months\n* Exacerbation within 4 weeks of recruitment\n* Preterm birth (≤36 weeks gestation) or perinatal complications\n* History of other pulmonary disorders\n* Specialist\u002FRespirologist suspects primary ciliary dyskinesia (PCD)\n* Current use of mucolytic medications\n* Memory, cognitive, or psychiatric limitations that may prevent optimal participation\n* Treatment with current biologic therapy: anti-IgE mAb within 130 days, anti-IL-4\u002F4R, IL-5\u002F5R, IL-13, or TSLP within 2 months or 5 half-lives whichever is longer prior to visit 1",true,"ALL","18 Years",{"count":136,"type":137},240,"ESTIMATED","OBSERVATIONAL","Chronic lung diseases affect one in five Canadians, causing symptoms such as cough, breathlessness, and wheeze. Despite advancements in medical care, these conditions not only impact individuals and their close circles but also present substantial clinical and economic challenges at a national level. This grant is dedicated to addressing three prevalent lung diseases: asthma, chronic obstructive pulmonary disease (COPD), and chronic cough. An alliance of clinicians, scientists, knowledge users, and patient partners from across Canada have come together to establish the Canadian Consortium for Understanding the Role of Airway Mucus Occlusions in Asthma, COPD, and Chronic Cough - \"CANMuc.\" Mucus plays a pivotal role in the symptoms and severity of lung diseases, but its clinical assessment has been challenging. Fortunately, recent medical advances, particularly chest computed tomography (CT), facilitate visualizing and quantifying mucus in patients with lung diseases. Our goal is to initially assess mucus plugging in a diverse group of Canadians without lung disease and then compare these findings to those with asthma, COPD, and chronic cough. The investigators will recruit 100 healthy volunteers for comprehensive clinical and research evaluations, including sputum analyses, breathing tests, quality of life assessments, cough monitoring, and CT scans. In addition, testing will be conducted twice, two years apart, in 240 adult and 50 pediatric participants. This approach will enable the investigators to understand the burden of mucus and how it changes over time, explore proteins or chemicals in mucus that predict mucus persistence, and identify biomarkers that can help guide physicians to prescribe targeted treatments that might work better than others. The CANMuc team's findings will guide strategies for identifying and treating mucus plugging, inform policymakers, and share knowledge with Canadians living with asthma, COPD, and chronic cough.",[9,14,141],"Chronic Cough (CC)",[143,144,141,14],"mucus occlusions","asthma","2026-01-05",{"date":147,"type":148},"2026-01-07","ACTUAL",{"date":150,"type":148},"2025-12-11",{"date":152,"type":137},"2028-04",{"name":5,"class":6},6]