[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100560356":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":32,"locations":41,"responsibleParty":59,"collaborators":62,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":18,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":18,"overallStatus":44,"whyStopped":18,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Cannabis Abstinence (CB-Abst)","EXPERIMENTAL","Those randomized to the abstinence condition will be asked to stop using cannabis for eight weeks. They will participate in a contingency management protocol, which uses an escalating remuneration schedule to incentivize abstinence. Abstinence is confirmed biochemically via progressively decreasing values of creatinine-adjusted THCCOOH.",[13],"Behavioral: Contingency management for cannabis abstinence",{"label":15,"type":16,"description":17,"interventionNames":18},"Cannabis Monitoring (CB-Mon)","NO_INTERVENTION","Those randomized to the monitoring condition will be asked to make no changes to their cannabis use frequency or dose for the duration of the eight week study.",null,{"label":20,"type":16,"description":21,"interventionNames":18},"Pre-intervention Pooled Groups (EMA Phase 1 Only)","All enrolled participants will participate in approximately two weeks of EMA data collection prior to being randomized and starting intervention procedures to characterize mood during baseline use as usual (CB-Abst or CB-Mon).",[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":18},"BEHAVIORAL","Contingency management for cannabis abstinence","Those randomized to the abstinence condition (CB-Abst) will be incentivized using an escalating reinforcement schedule for eight weeks of cannabis abstinence.",[9],[29],{"name":30,"affiliation":5,"role":31},"Randi M Schuster, PhD","PRINCIPAL_INVESTIGATOR",[33,37],{"name":30,"role":34,"phone":35,"phoneExt":18,"email":36},"CONTACT","617-643-6673","rschuster@mgh.harvard.edu",{"name":38,"role":34,"phone":39,"phoneExt":18,"email":40},"Julia Jashinski, MSW","617-643-1984","jjashinski@mgh.harvard.edu",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Massachusetts General Hopsital","RECRUITING","Boston","Massachusetts","02114","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-71.05977,42.35843,{"lat":54,"lon":53},[57,58],{"name":30,"role":34,"phone":35,"phoneExt":18,"email":36},{"name":38,"role":34,"phone":39,"phoneExt":18,"email":40},{"type":31,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Randi Melissa Schuster","Associate Professor; Director of School-Based Research and Program Development",[63],{"name":64,"class":65},"National Institute on Drug Abuse (NIDA)","NIH","100560356","cannabis-linked-emotions-and-adolescent-risk-study-100560356",false,"NCT06576076","Cannabis, Linked Emotions, and Adolescent Risk Study","Characterizing Proximal Risk for Depressive Symptoms and Suicidal Ideation With Acute Cannabis Use and Withdrawal Among Adolescents Using Ecological Momentary Assessment","CLEAR","Inclusion Criteria:\n\n* Ages 12-18;\n* Current daily or near daily cannabis use (i.e., use ≥ 4 days per week on average; Timeline Followback);\n* Score ≥ 5 on PHQ-9;\n* Access to an internet-capable smartphone (iOS or Android);\n* Provision of at least 1 collateral contact for risk monitoring;\n* Provision of informed assent (or consent if 18 years or older) and parent\u002Fguardian consent if \\\u003Cage 18;\n* Greater than 50% response rate to EMA prompts during the first EMA phase;\n* No immediate plan to discontinue cannabis use in the next 3 months;\n* Positive toxicology result for cannabis on baseline urinalysis.\n\nExclusion Criteria:\n\n* Any factor that impairs ability to comprehend and effectively participate, including acute intoxication at time of consent;\n* Cannabis use \\>4 times\u002Fday on average (to maximize likelihood of capturing mood and SI during non-use times);\n* Inability to speak\u002Fwrite English fluently;\n* Gross cognitive impairment, for example due to florid psychosis, intellectual disability, developmental delay, or neurodegenerative disease;\n* Current epilepsy diagnosis;\n* Individuals who are under the legal protection of the government or state (wards of the state);\n* Response of \"No\" to the knowledge check question regarding EMA suicidality response time;\n* Inability to wear Fitbit device.","ALL","12 Years","18 Years",{"count":78,"type":79},200,"ESTIMATED","INTERVENTIONAL",[82],"NA","The goal of this study is to disentangle relationships between acute cannabis use and withdrawal on proximal depression and suicide risk and recovery in adolescents ages 12-18 years by incorporating time-varying patterns of substance use, mood, and SI. This project aims to guide the development of scalable, individualized, accessible, and affordable interventions aimed to reduce depression and suicide risk among adolescents.",[85,86,87,88],"Cannabis Use","Depression","Suicidal Ideation","Adolescent Behavior","2026-02-27",{"date":91,"type":92},"2026-03-03","ACTUAL",{"date":94,"type":92},"2025-02-18",{"date":96,"type":79},"2029-04-30",{"name":5,"class":6},1]